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  2. Tert - telomerase reverse transcriptase Gene

Tert - telomerase reverse transcriptase Gene

中文名称:端粒酶逆转录酶

种属: Mus musculus

同用名: TR; TP2; TRT; EST2; TCS1

基因 ID: 21752 | 基因类型: protein coding

关于 Tert

Chromosome 13: 73,775,030-73,797,962 forward strand.GRCm39:CM001006.3

This gene has 7 transcripts (splice variants), 188 orthologues and is associated with 33 phenotypes. Broad expression in limb E14.5 (RPKM 4.7), adrenal adult (RPKM 3.6) and 25 other tissues.

功能概要

该基因编码的蛋白可启动端粒酶 RNA 结合活性;端粒酶活性;和转录辅激活因子结合活性。参与Wnt信号通路的正向调控;毛发周期的正调节;和干细胞增殖的正调控。在葡萄糖输入的上游或正调节范围内起作用。位于线粒体和质膜中。端粒酶催化核心复合物的一部分。以多种结构表达,包括早期孕体;泌尿生殖系统;淋巴系统腺体;肝;和触须毛囊。该基因的人类直系同源物与多种疾病有关,包括常染色体显性先天性角化不良 2;家族性黑色素瘤;肝细胞癌;特发性肺纤维化;和白血病(多种)。与人类 TERT(端粒酶逆转录酶)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables Telomerase RNA binding activity; Telomerase activity; and transcription coactivator binding activity. Involved in positive regulation of Wnt signaling pathway; positive regulation of hair cycle; and positive regulation of stem cell proliferation. Acts upstream of or within positive regulation of glucose import. Located in mitochondrion and plasma membrane. Part of Telomerase catalytic core complex. Is expressed in several structures, including early conceptus; genitourinary system; hemolymphoid system gland; liver; and vibrissa follicle. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant dyskeratosis congenita 2; familial melanoma; hepatocellular carcinoma; idiopathic pulmonary fibrosis; and leukemia (multiple). Orthologous to human TERT (telomerase Reverse Transcriptase). [provided by Alliance of Genome Resources, Apr 2022]

Tert 基因产物(3)

mRNA Protein Name
NM_001362387.1 NP_001349316.1 telomerase reverse transcriptase isoform 2
NM_001362388.1 NP_001349317.1 telomerase reverse transcriptase isoform 3
NM_009354.2 NP_033380.1 telomerase reverse transcriptase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IPI
IPI: 通过物理相互作用推断
16507993 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17130244 MGI
enables telomerase RNA binding IPI
IPI: 通过物理相互作用推断
16507993 MGI
enables telomerase activity IDA
IDA: 通过直接分析推断
14701760 MGI
enables transcription coactivator binding IPI
IPI: 通过物理相互作用推断
19571879 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of D-glucose import IMP
IMP: 通过突变表型推断
24970747 MGI
involved in positive regulation of Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
19571879 MGI
involved in positive regulation of hair cycle IMP
IMP: 通过突变表型推断
16037417 MGI
involved in positive regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
16037417 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
24970747 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
21937513 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
24970747 MGI
part of telomerase catalytic core complex IMP
IMP: 通过突变表型推断
16037417 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Tert 蛋白结构

Telomerase_RBD

Telomerase_RBD: pfam12009 (449 - 581)

TERT

TERT: cd01648 (814 - 928)

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  • 1122 a.a.
蛋白主名 其他名称

telomerase reverse transcriptase

telomerase catalytic subunit

telomerase reverse transcriptase beta

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tert NCBI NCBI:7015