Cdk13 - cyclin-dependent kinase 13 Gene

中文名称：细胞周期蛋白依赖性激酶 13

种属: Rattus norvegicus

同用名: Cdc2l5

关于 Cdk13

功能概要

预测该基因编码的蛋白可启动细胞周期蛋白结合活性；蛋白激酶结合活性；和蛋白丝氨酸/苏氨酸激酶活性。预计参与RNA代谢过程；造血作用； RNA 聚合酶 II 对转录的调控。预计在干细胞分化的负调节上游或负调节内起作用。预测位于高尔基体；胞质溶胶；和核斑点。预测为细胞周期蛋白 K-CDK13 复合物和细胞周期蛋白/CDK 阳性转录延伸因子复合物的一部分。预计活跃于核心。该基因的人类直系同源物与先天性心脏病、畸形面部特征和智力发育障碍有关。与人 CDK13（细胞周期蛋白依赖性激酶 13）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable cyclin binding activity; protein kinase binding activity; and protein serine/threonine kinase activity. Predicted to be involved in RNA metabolic process; hemopoiesis; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of stem cell differentiation. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be part of cyclin K-CDK13 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in congenital heart defects, dysmorphic facial features, and intellectual developmental disorder. Orthologous to human CDK13 (cyclin dependent kinase 13). [provided by Alliance of Genome Resources, Apr 2022]