HLA-DMA - major histocompatibility complex, class II, DM alpha Gene

中文名称：主要组织相容性复合体，II 类，DM α

种属: Homo sapiens

同用名: DMA; HLADM; RING6; D6S222E

基因 ID: 3108 | 基因类型: protein coding

关于 HLA-DMA

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,948,618-32,953,097 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele, 111 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 124.3), lung (RPKM 102.4) and 24 other tissues.

功能概要

HLA-DMA 属于 HLA II 类α链旁系同源物。这种 II 类分子是一种异二聚体，由一条 alpha (DMA) 和一条 beta 链 (DMB) 组成，两者都锚定在膜中。它位于细胞内囊泡中。 DM 通过帮助从肽结合位点释放 CLIP 分子，在 MHC II 类分子的肽加载中起着核心作用。 II 类分子在抗原呈递细胞 (APC：B 淋巴细胞、树突细胞、巨噬细胞) 中表达。 α 链约为 33-35 kDa，其基因包含 5 个外显子。外显子 1 编码前导肽，外显子 2 和 3 编码两个细胞外结构域，外显子 4 编码跨膜结构域和细胞质尾部。[RefSeq 提供，2008 年 7 月]

HLA-DMA belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DMA 基因产物(1)

mRNA	Protein	Name
NM_006120.4	NP_006111.2	HLA class II histocompatibility antigen, DM alpha chain precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MHC class II protein complex binding	IDA IDA: 通过直接分析推断	9075930	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21131964	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in peptide antigen assembly with MHC class II protein complex	IDA IDA: 通过直接分析推断	7606781	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MHC class II protein complex	IDA IDA: 通过直接分析推断	7606781	GOA
located in cell surface	IDA IDA: 通过直接分析推断	22247549	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	9075930	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	9075930	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HLA-DMA 蛋白结构

MHC_II_alpha

C1-set

0
100
200
261 a.a.

蛋白主名

其他名称

HLA class II histocompatibility antigen, DM alpha chain

MHC class II antigen DMA

重组 HLA-DMA 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71463	HLA-DMA Protein, Human (His)	Q6ICR9 (V27-C233)	≥95%

关联疾病

疾病名称

别名

Chediak-Higashi Syndrome

CHS	Chédiak-Higashi Syndrome
Chediak - Steinbrinck Anomaly	Chediak Higashi Syndrome
Chediak-Steinbrinck-Higashi Syndrome	Oculocutaneous Albinism With Leukocyte Defect
Chediak-Higashi Disease	Chediak-Higashi-Steinbrink Syndrome

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Celiac Disease 1

Celiac Disease	Coeliac Disease
Celiac Sprue	Celiac Disease, Susceptibility To
Gluten-Sensitive Enteropathy	Nontropical Sprue
Sprue	CELIAC1
Celiac Disease, Susceptibility To, 1	Celiac Sprue 1
Celiac Sprue, Susceptibility To, 1	Gluten-Sensitive Enteropathy 1
Gluten-Sensitive Enteropathy, Susceptibility To, 1	Idiopathic Steatorrhea
Cœliac Disease	Gluten Intolerance
Gluten-Induced Enteropathy	Gluten Enteropathy
Celiac Disease, Susceptibility To, Type 1	Childhood Celiac Disease
Coeliac Rickets	Gee Disease
Gee-Herter Disease	Heubner-Herter Disease
Idiopathic Steatorrhoea	Thaysen'S Disease
Herter Gee Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06199	HLA-DMA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HLA-DMA	RGD	RGD:735053
Mus musculus	HLA-DMA	MGD	MGI:95921

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HLA-DMA - major histocompatibility complex, class II, DM alpha Gene

关于 HLA-DMA

功能概要

HLA-DMA 基因产物(1)

HLA-DMA 蛋白结构

重组 HLA-DMA 蛋白

关联疾病

直系同源

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HLA-DMA - major histocompatibility complex, class II, DM alpha Gene

关于 HLA-DMA

功能概要

HLA-DMA 基因产物(1)

HLA-DMA 蛋白结构

重组 HLA-DMA 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z