HLA-DMB - major histocompatibility complex, class II, DM beta Gene

中文名称：主要组织相容性复合体，II 类，DM beta

种属: Homo sapiens

同用名: RING7; D6S221E

基因 ID: 3109 | 基因类型: protein coding

关于 HLA-DMB

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:32,934,636-32,941,028 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 149 orthologues and 13 paralogues. Broad expression in lymph node (RPKM 104.0), spleen (RPKM 76.5) and 24 other tissues.

功能概要

HLA-DMB 属于 HLA II 类β链旁系同源物。这种 II 类分子是一种异二聚体，由一条 alpha (DMA) 和一条 beta (DMB) 链组成，它们都锚定在膜中。它位于细胞内囊泡中。 DM 通过帮助从肽结合位点释放 CLIP (II 类相关不变链肽) 分子，在 MHC II 类分子的肽加载中起着核心作用。 II 类分子在抗原呈递细胞 (APC：B 淋巴细胞、树突细胞、巨噬细胞) 中表达。 β链约为 26-28 kDa，其基因包含 6 个外显子。外显子 1 编码前导肽，外显子 2 和 3 编码两个细胞外结构域，外显子 4 编码跨膜结构域，外显子 5 编码细胞质尾部。[RefSeq 提供，2008 年 7 月]

HLA-DMB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta (DMB) chain, both anchored in the membrane. It is located in intracellular vesicles. DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008]

HLA-DMB 基因产物(1)

mRNA	Protein	Name
NM_002118.5	NP_002109.2	HLA class II histocompatibility antigen, DM beta chain precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MHC class II protein complex binding	IDA IDA: 通过直接分析推断	9075930	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21131964	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in MHC class II protein complex assembly	IMP IMP: 通过突变表型推断	8139689	GOA
involved in antigen processing and presentation of exogenous peptide antigen via MHC class II	IMP IMP: 通过突变表型推断	8139689	GOA
involved in peptide antigen assembly with MHC class II protein complex	IDA IDA: 通过直接分析推断	7606781	GOA
involved in positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	IMP IMP: 通过突变表型推断	8139689	GOA
involved in positive regulation of T cell proliferation	IMP IMP: 通过突变表型推断	8139689	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of MHC class II protein complex	IDA IDA: 通过直接分析推断	7606781	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	9075930	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	9075930	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HLA-DMB 蛋白结构

C1-set

0
100
141 a.a.

蛋白主名

其他名称

HLA class II histocompatibility antigen, DM beta chain

MHC class II HLA-DMB

HLA-DMB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HLA-DMB	P28068	AP3M1	Homo sapiens	Q9Y2T2	Anti Tag CoIP	33961781
种属内	HLA-DMB	P28068	AP3M1	Homo sapiens	Q9Y2T2	Anti Tag CoIP	28514442
种属内	HLA-DMB	P28068	HLA-DMA	Homo sapiens	P28067	X-Ray Diffraction	9768757

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Psychologic Dyspareunia

Dyspareunia, Psychogenic

Non-Organic Dyspareunia

Type 1 Diabetes Mellitus

Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus Type 1
IDDM	Type 1 Diabetes
Insulin-Dependent Diabetes Mellitus	T1D
Juvenile-Onset Diabetes	Jod
Diabetes Mellitus, Type 1	Diabetes Mellitus, Insulin-Dependent-1
Type I Diabetes Mellitus	Autoimmune Diabetes
Juvenile Diabetes	Juvenile-Onset Diabetes Mellitus
Diabetes, Insulin Dependent	Insulin-Dependent Diabetes Mellitus-1
Diabetes Mellitus Insulin-Dependent	Diabetes Autoimmune
Diabetes Mellitus, Insulin-Dependent, Susceptibility To	Diabetes Mellitus, Type 1, Susceptibility To
Diabetes Type 1	Type I Diabetes
Diabetes, Autoimmune	T1dm - [Type 1 Diabetes Mellitus]
Iddm - [Insulin Dependent Diabetes Mellitus]	Type 1 Iddm
Juvenile Diabetes Mellitus Without Compications	Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications
Juvenile-Onset Diabetes Mellitus Without Compications	Ketosis-Prone Diabetes Mellitus Without Compications
Juvenile-Onset-Type Diabetes Mellitus Without Compications

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Severe Combined Immunodeficiency

Scid	Severe Combined Immunodeficiency Disease
Combined T And B Cell Inborn Immunodeficiency	Immunodeficiency, Severe Combined
Scid - [Severe Combined Immunodeficiencies]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06200	HLA-DMB Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	HLA-DMB	RGD	RGD:735096

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HLA-DMB - major histocompatibility complex, class II, DM beta Gene

关于 HLA-DMB

功能概要

HLA-DMB 基因产物(1)

HLA-DMB 蛋白结构

HLA-DMB 蛋白互作信息

关联疾病

直系同源

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HLA-DMB - major histocompatibility complex, class II, DM beta Gene

关于 HLA-DMB

功能概要

HLA-DMB 基因产物(1)

HLA-DMB 蛋白结构

HLA-DMB 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z