MR1 - major histocompatibility complex, class I-related Gene

中文名称：主要组织相容性复合体，I 类相关

种属: Homo sapiens

同用名: HLALS

基因 ID: 3140 | 基因类型: protein coding

关于 MR1

Cytogenetic location: 1q25.3 Genomic coordinates (GRCh38): 1:181,033,387-181,061,938 (from NCBI)

This gene has 12 transcripts (splice variants), 649 orthologues and 22 paralogues. Ubiquitous expression in urinary bladder (RPKM 6.3), thyroid (RPKM 5.6) and 24 other tissues.

功能概要

MAIT (粘膜相关不变性 T 细胞) 淋巴细胞代表了一小群主要存在于肠道中的 T 细胞。该基因编码的蛋白质是一种抗原呈递分子，可将微生物维生素 B 的代谢物呈递给 MAIT。该演示文稿可能会激活 MAIT 以调节肠道中特定类型细菌的数量。已发现该基因编码不同同种型的几种转录变体，并且已在同一染色体上游约 36 kbp 处检测到它的假基因。[RefSeq 提供，2015 年 7 月]

MAIT (mucosal-associated invariant T-cells) lymphocytes represent a small population of T-cells primarily found in the gut. The protein encoded by this gene is an antigen-presenting molecule that presents metabolites of microbial vitamin B to MAITs. This presentation may activate the MAITs to regulate the amounts of specific types of bacteria in the gut. Several transcript variants encoding different isoforms have been found for this gene, and a pseudogene of it has been detected about 36 kbp upstream on the same chromosome. [provided by RefSeq, Jul 2015]

MR1 基因产物(9)

mRNA	Protein	Name
NM_001194999.2	NP_001181928.1	major histocompatibility complex class I-related gene protein isoform 2 precursor
NM_001195000.2	NP_001181929.1	major histocompatibility complex class I-related gene protein isoform 3 precursor
NM_001195035.2	NP_001181964.1	major histocompatibility complex class I-related gene protein isoform 4 precursor
NM_001310213.2	NP_001297142.1	major histocompatibility complex class I-related gene protein isoform 5
NM_001385161.1	NP_001372090.1	major histocompatibility complex class I-related gene protein isoform 1 precursor
NM_001385162.1	NP_001372091.1	major histocompatibility complex class I-related gene protein isoform 6 precursor
NM_001385163.1	NP_001372092.1	major histocompatibility complex class I-related gene protein isoform 7 precursor
NM_001385164.1	NP_001372093.1	major histocompatibility complex class I-related gene protein isoform 3 precursor
NM_001531.3	NP_001522.1	major histocompatibility complex class I-related gene protein isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables T cell receptor binding	IDA IDA: 通过直接分析推断	26795251	GOA
enables beta-2-microglobulin binding	IDA IDA: 通过直接分析推断	26795251	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	23051753	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antigen processing and presentation of exogenous antigen	IDA IDA: 通过直接分析推断	27043408	GOA
involved in defense response to Gram-negative bacterium	IDA IDA: 通过直接分析推断	20581831	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: 通过直接分析推断	27527800	GOA
involved in positive regulation of T cell mediated cytotoxicity directed against tumor cell target	IDA IDA: 通过直接分析推断	31959982	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in early endosome membrane	IDA IDA: 通过直接分析推断	27043408	GOA
located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	21190736	GOA
located in endoplasmic reticulum membrane	IDA IDA: 通过直接分析推断	27043408	GOA
located in late endosome membrane	IDA IDA: 通过直接分析推断	27043408	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	27043408	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MR1 蛋白结构

MHC_I

C1-set

0
100
200
300
341 a.a.

蛋白主名

其他名称

major histocompatibility complex class I-related gene protein

MHC class I-like antigen MR-1

MR1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	MR1	Q95460	FATE1	Homo sapiens	Q969F0	Y2H Array	25416956
种属内	MR1	Q95460	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency
Primary Immunodeficiency Disease	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Hemochromatosis, Type 1

Hemochromatosis	Hemochromatosis Type 1
Hereditary Hemochromatosis	Hh
HFE1	Hfe Hemochromatosis, Modifier Of
Symptomatic Form Of Classic Hemochromatosis	Symptomatic Form Of Hemochromatosis Type 1
Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis	Haemochromatosis
Iron Storage Disorder	Bronze Diabetes
Hereditary Haemochromatosis	Hlah
Hfe	Hemochromatosis, Hereditary
Diabetes Bronze	Classic Hemochromatosis
Hfe-Associated Hereditary Hemochromatosis	Hemochromatosis Classic
Bronzed Cirrhosis	Familial Hemochromatosis
Genetic Hemochromatosis	Hc
Pigmentary Cirrhosis	Primary Hemochromatosis
Troisier-Hanot-Chauffard Syndrome	Von Recklenhausen-Applebaum Disease
Hemochromatosis 1	Primary Hereditary Hemochromatosis
Bronze Cirrhosis

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-124004	Acetyl-6-formylpterin		≥95.0%	否
HY-157194	RL-6-Me-7-OH		96.56%	否
HY-157281	Photolumazine III		99.96%	否
HY-W168754	DB28	Inhibitor	/	否
HY-157200	2,4-DA-6-FP		/	否
HY-RS08637	MR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-157282	Photolumazine I		/	否
HY-163122	5-Formylsalicylic acid		/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990134	Anti-Mouse CD40L/CD154 Antibody (MR-1)	Inhibitor	95.00%	否
HY-P990270	Anti-Mouse CD40L/CD154 (D265A) Antibody (MR-1)		/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	MR1	VGNC	VGNC:100013
Mus musculus	MR1	MGD	MGI:1195463
Bos taurus	MR1	VGNC	VGNC:31595
Rattus norvegicus	MR1	RGD	RGD:1593291
Macaca fascicularis	MR1	NCBI
Others	MR1	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

MR1 - major histocompatibility complex, class I-related Gene

关于 MR1

功能概要

MR1 基因产物(9)

MR1 蛋白结构

MR1 蛋白互作信息

关联疾病

直系同源

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MR1 - major histocompatibility complex, class I-related Gene

关于 MR1

功能概要

MR1 基因产物(9)

MR1 蛋白结构

MR1 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z