HMGB2 - high mobility group box 2 Gene

中文名称：高机动性组框 2

种属: Homo sapiens

同用名: HMG2

关于 HMGB2

功能概要

该基因编码非组蛋白染色体高迁移率族蛋白家族的成员。该家族的蛋白质与染色质相关，普遍分布于高等真核细胞的细胞核中。体外研究表明，这种蛋白质能够有效地弯曲 DNA 并形成 DNA 环。这些研究表明通过促进 DNA 的灵活性在促进顺式作用蛋白之间的协同相互作用方面发挥作用。据报道，该蛋白质还参与了 DNA 双链断裂修复和 V (D) J 重组的 DNA 末端连接过程的最后连接步骤。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein was also reported to be involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. [provided by RefSeq, Jul 2008]