2. Gene
  3. HPCA - hippocalcin Gene

HPCA - hippocalcin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：海马钙素

种属: Homo sapiens

同用名: BDR2; DYT2

基因 ID: 3208 | 基因类型: protein coding

关于 HPCA

Cytogenetic location: 1p35.1 Genomic coordinates (GRCh38): 1:32,885,996-32,894,646 (from NCBI)

This gene has 5 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 2 phenotypes. Restricted expression toward brain (RPKM 57.7).

功能概要

由该基因编码的蛋白质是在视网膜和大脑中发现的神经元特异性钙结合蛋白家族的成员。这种蛋白质与质膜相关。它与位于感光细胞中的蛋白质有相似之处，这些蛋白质以钙敏感的方式调节光信号转导。这种蛋白质表现出恢复素活性和视紫红质激酶的钙依赖性抑制作用。它与大鼠和小鼠的海马钙蛋白相同，被认为在许多物种的中枢神经系统神经元中发挥重要作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of neuron-specific calcium-binding proteins family found in the retina and brain. This protein is associated with the plasma membrane. It has similarities to proteins located in the photoreceptor cells that regulate photosignal transduction in a calcium-sensitive manner. This protein displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase. It is identical to the rat and mouse hippocalcin proteins and thought to play an important role in neurons of the central nervous system in a number of species. [provided by RefSeq, Jul 2008]

HPCA 基因产物(1)

mRNA Protein Name
NM_002143.3 NP_002134.2 neuron-specific calcium-binding protein hippocalcin
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables actin binding IDA
IDA: 通过直接分析推断
11964161 GOA
enables calcium ion binding IDA
IDA: 通过直接分析推断
28398555 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
28398555 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to calcium ion IMP
IMP: 通过突变表型推断
28398555 GOA
involved in regulation of voltage-gated calcium channel activity IMP
IMP: 通过突变表型推断
28398555 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
28398555 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HPCA 蛋白结构

EF-hand_1

EF-hand_1: EF hand (66 - 90)

EF-hand_7

EF-hand_7: EF-hand domain pair (100 - 171)

  • 0
  • 100
  • 193 a.a.
蛋白主名 其他名称

neuron-specific calcium-binding protein hippocalcin

calcium-binding protein BDR-2

HPCA 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra HPCA P84074 CKMT1A Homo sapiens P12532
Y2H Array
32296183
Intra HPCA P84074 CKMT1A Homo sapiens P12532
Y2H Prey Pooling
32296183
Intra HPCA P84074 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra HPCA P84074 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Intra HPCA P84074 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra HPCA P84074 VWC2 Homo sapiens Q2TAL6
Y2H Prey Pooling
32296183
Intra HPCA P84074 VWC2 Homo sapiens Q2TAL6
Validated Y2H
32296183
Intra HPCA P84074 VWC2 Homo sapiens Q2TAL6
Y2H Array
32296183
Intra HPCA P84074 GATA5 Homo sapiens Q9BWX5
Y2H Prey Pooling
32296183
Intra HPCA P84074 GATA5 Homo sapiens Q9BWX5
Y2H Array
32296183
Intra HPCA P84074 GATA5 Homo sapiens Q9BWX5
Validated Y2H
32296183
Intra HPCA P84074 MLLT10 Homo sapiens P55197-2
Y2H Prey Pooling
32296183
Intra HPCA P84074 MLLT10 Homo sapiens P55197-2
Y2H Array
32296183
Intra HPCA P84074 CREM Homo sapiens Q03060-25
Validated Y2H
32296183
Intra HPCA P84074 CREM Homo sapiens Q03060-25
Y2H Array
32296183
Intra HPCA P84074 CREM Homo sapiens Q03060-25
Y2H Prey Pooling
32296183
Intra HPCA P84074 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Prey Pooling
32296183
Intra HPCA P84074 C1QTNF2 Homo sapiens Q9BXJ5
Validated Y2H
32296183
Intra HPCA P84074 C1QTNF2 Homo sapiens Q9BXJ5
Y2H Array
32296183
Intra HPCA P84074 IL36RN Homo sapiens Q9UBH0
Validated Y2H
32296183
Intra HPCA P84074 MYDGF Homo sapiens Q969H8
Validated Y2H
32296183
Intra HPCA P84074 MYDGF Homo sapiens Q969H8
Y2H Array
32296183
Intra HPCA P84074 MYDGF Homo sapiens Q969H8
Y2H Prey Pooling
32296183
Intra HPCA P84074 DTX2 Homo sapiens Q86UW9
Anti Tag CoIP
33961781
Intra HPCA P84074 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra HPCA P84074 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra HPCA P84074 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra HPCA P84074 UQCRB Homo sapiens P14927
Y2H Prey Pooling
32296183
Intra HPCA P84074 UQCRB Homo sapiens P14927
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dystonia 2, Torsion, Autosomal Recessive

DYT2

Dystonia Musculorum Deformans 2

Torsion Dystonia 2

Dystonia Musculorum Deformans Type 2

Torsion Dystonia 2, Autosomal Recessive Type

Primary Dystonia, Dyt2 Type

Dystonia, Type 2, Torsion, Autosomal Recessive
Torsion Dystonia 2

Dystonia 2, Torsion, Autosomal Recessive
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Dystonia 25

DYT25

Dystonia-25

Dystonia, Type 25
Torsion Dystonia 4
Dystonia 6, Torsion

DYT6

Torsion Dystonia 6

Dystonia 6

Idiopathic Torsion Dystonia Of Mixed Type

Primary Dystonia, Dyt6 Type

Torsion Dystonia, Adult-Onset, Mixed Type

Dyt-Thap1

Adolescent-Onset Dystonia Of Mixed Type

Torsion Dystonia Adult Onset Mixed Type

Dyt6 Dystonia

Thap1 Dystonia

Generalized Cervical And Upper-Limb-Onset Dystonia

Adult-Onset Torsion Dystonia Mixed Type

Autosomal Dominant Torsion Dystonia 6

Dystonia-6

Torsion Dystonia Type 6

Dystonia, Type 6, Torsion
Dystonia 27

DYT27

Primary Dystonia, Dyt27 Type

Dystonia, Type 27
Spastic Monoplegia

Monoplegic Infantile Cerebral Palsy

Spastic Monoplegic Cerebral Palsy

Infantile Monoplegic Cerebral Palsy

Cerebral Palsy Spastic Monoplegic

Spastic Monoplegia Cerebral Palsy
Dystonia 24

DYT24

Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement

Dystonia-24

Dystonia, Type 24
Dystonia 1, Torsion, Autosomal Dominant

Dystonia Musculorum Deformans 1

Dystonia Musculorum Deformans

DYT1

Early-Onset Torsion Dystonia

Eotd

Dystonia-1, Torsion

Torsion Dystonia 1

Autosomal Dominant Torsion Dystonia 1

Dystonia-1

Oppenheim'S Dystonia

Oppenheim-Ziehen Disease

Early Onset Torsion Dystonia

Dystonia 3, Torsion, X-Linked
Segmental Dystonia
Multifocal Dystonia
Ascending Cholangitis
Spasmodic Dystonia

Laryngeal Dystonia
Dystonia 12

DYT12

Rdp

Generalized Dystonia

Dystonia-12

Rapid-Onset Dystonia-Parkinsonism

Familial Dystonia

Dystonia Musculorum Deformans

Dystonic Disorders

Idiopathic Familial Dystonia

Dystonia-Parkinsonism, Rapid-Onset

Fragments Of Torsion Dystonia

Dyt-Atp1a3

Rapid-Onset Dystonia Parkinsonism

Rodp

Dystonia, Type 12

Dystonia 3, Torsion, X-Linked

Idiopathic Non-Familial Dystonia

Symptomatic Torsion Dystonia

Dystonia Disorders
Leukodystrophy, Hypomyelinating, 6

Habc

Hypomyelinating Leukodystrophy 6

HLD6

H-Abc

Hypomyelination With Atrophy Of Basal Ganglia And Cerebellum

Leukodystrophy, Hypomyelinating, With Atrophy Of The Basal Ganglia And Cerebellum

Hypomyelinating Leukodystrophy With Atrophy Of The Basal Ganglia And Cerebellum

HLD

Leukodystrophy, Hypomyelinating, Type 6
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06333 HPCA Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus HPCA RGD RGD:620060
Mus musculus HPCA MGD MGI:1336200
Macaca mulatta HPCA VGNC VGNC:73509
Felis catus HPCA VGNC VGNC:67635
Bos taurus HPCA VGNC VGNC:29936
Canis familiaris HPCA VGNC VGNC:52136
Others HPCA NCBI
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