HPGD - 15-hydroxyprostaglandin dehydrogenase Gene

中文名称：15-羟基前列腺素脱氢酶

种属: Homo sapiens

同用名: PGDH; PGDH1; PHOAR1; 15-PGDH; SDR36C1

基因 ID: 3248 | 基因类型: protein coding

关于 HPGD

Cytogenetic location: 4q34.1 Genomic coordinates (GRCh38): 4:174,490,175-174,522,893 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and is associated with 6 phenotypes. Biased expression in urinary bladder (RPKM 176.8), stomach (RPKM 67.9) and 11 other tissues.

功能概要

该基因编码短链非金属酶醇脱氢酶蛋白家族的成员。编码的酶负责前列腺素的代谢，前列腺素在多种生理和细胞过程中发挥作用，例如炎症。该基因的突变导致原发性常染色体隐性肥厚性骨关节病和颅骨关节病。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2009 年 3 月]

This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded Enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

HPGD 基因产物(8)

mRNA	Protein	Name
NM_001256305.2	NP_001243234.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4
NM_001363574.2	NP_001350503.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 6
NM_001256301.1	NP_001243230.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
XR_938728.3
NM_000860.6	NP_000851.2	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1
NM_001256307.2	NP_001243236.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3
NM_001256306.2	NP_001243235.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5
NM_001145816.3	NP_001139288.1	15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	2025296	GOA
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity	IMP IMP: 通过突变表型推断	8086429	GOA
enables NAD binding	IDA IDA: 通过直接分析推断	10198228	GOA
enables NAD+ binding	IDA IDA: 通过直接分析推断	16828555	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	21072165	GOA
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IDA IDA: 通过直接分析推断	16757471	GOA
enables prostaglandin E receptor activity	IDA IDA: 通过直接分析推断	10198228	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in female pregnancy	IDA IDA: 通过直接分析推断	15531523	GOA
involved in negative regulation of cell cycle	IDA IDA: 通过直接分析推断	15574495	GOA
involved in parturition	IDA IDA: 通过直接分析推断	15531523	GOA
involved in prostaglandin metabolic process	IDA IDA: 通过直接分析推断	16828555	GOA
involved in regulation of prostaglandin catabolic process	IMP IMP: 通过突变表型推断	8086429	GOA
involved in transforming growth factor beta receptor signaling pathway	IDA IDA: 通过直接分析推断	15574495	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HPGD 蛋白结构

adh_short

0
100
200
266 a.a.

蛋白主名

其他名称

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

15-hydroxyprostaglandin dehydrogenase (NAD(+))	NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
eicosanoid/docosanoid dehydrogenase	hydroxyprostaglandin dehydrogenase 15-(NAD)
prostaglandin dehydrogenase 1	short chain dehydrogenase/reductase family 36C member 1

重组 HPGD 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70297	15-PGDH/HPGD Protein, Human (HEK293, His)	P15428-1 (M1-Q266)	≥95%
HY-P75547	15-PGDH/HPGD Protein, Human (His)	P15428-1/NP_000851.2 (M1-Q266)	≥95%

关联疾病

疾病名称

别名

Colorectal Adenoma

Colorectal Adenomas

Adenoma Of Large Intestine

Colon Adenoma

Adenomatous Polyp Of Colon

Gastric Tubular Adenocarcinoma

Tubular Adenocarcinoma Of Stomach

Gastritis, Familial Giant Hypertrophic

Menetrier Disease	Gastric Mucosal Hypertrophy
Giant Hypertrophic Gastritis	Hypertrophic Gastropathy
Gastritis, Hypertrophic	Familial Giant Hypertrophic Gastritis
Giant Rugal Hypertrophy Of Stomach	Hypertrophic Gastritis
Gastroenteropathy, Protein Losing	Giant Hypertrophic Gastropathy
Giant Hypertrophy Of The Gastric Mucosa	Hypoproteinemic Hypertrophic Gastropathy
Menetrier'S Disease	Giant Hypertrophic Hypersecretory Gastritis

Lung Cancer Susceptibility 3

Lung Adenocarcinoma	Adenocarcinoma Of Lung
LNCR3	Adenocarcinoma Of Lung, Susceptibility To
Bronchogenic Lung Adenocarcinoma	Nonsmall Cell Adenocarcinoma
Adenocarcinoma Lung	Lung Adenocarcinomas
Non-Small Cell Adenocarcinoma

Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1

Cranioosteoarthropathy	PHOAR1
Pachydermoperiostosis, Autosomal Recessive	Touraine-Solente-Gole Syndrome
Pho, Autosomal Recessive	Pdp, Autosomal Recessive
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive 1	Cranio Osteoarthropathy
Cranio-Osteoarthropathy	Currarino Disease
Currarino Idiopathic Osteoarthropathy	Reginato-Schiapachasse Syndrome
Touraine-Solente-Golé Syndrome	COA
Pachydermoperiostosis Autosomal Recessive	Pdp Autosomal Recessive
Pho Autosomal Recessive	Osteoarthropathy, Hypertrophic, Primary, Autosomal Recessive, Type 1
Osteoarthropathy, Primary Hypertrophic	Reginato Schiapachasse Syndrome

Patent Ductus Arteriosus 1

Patent Ductus Arteriosus	PDA1
Pda	Ductus Arteriosus, Patent
Patent Ductus Arteriosus, Susceptibility To	Patent Ductus Botalli
Patency Of The Ductus Arteriosus	Patent Ductus Arteriosus Familial
Ductus Arteriosus Patent	Patent Ductus Arteriosus - Persisting Type

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Primary Hypertrophic Osteoarthropathy

Pachydermoperiostosis Syndrome	Osteoarthropathy, Primary Hypertrophic
Pachydermoperiostosis Of Nail	Idiopathic Hypertrophic Osteoarthropathy
Pho

Acroosteolysis

Acro-Osteolysis

Ureteral Obstruction

Colonic Benign Neoplasm

Colon Neoplasm	Colonic Mass
Colonic Tumor	Neoplasm Of Colon
Neoplasm Of The Colon	Colonic Neoplasms
Colon Cancer	Colon Carcinoma Nos
Colonic Cancer	Metastatic Colon Cancer Nos

Lymphangioma

Lymphatic Malformation	Lymphatic Malformations
Benign Lymphangioma	Congenital Lymphangioma
Lymphangiomas

Periostitis

Digital Clubbing, Isolated Congenital

Isolated Congenital Digital Clubbing	DIGC
Clubbing Of Digits	Acropachy, Hereditary
Isolated Congenital Acropachy	Isolated Congenital Nail Clubbing
Hereditary Acropachy

Secondary Hypertrophic Osteoarthropathy

Osteoarthropathy, Secondary Hypertrophic	Bamberger-Marie Disease
Hpoa - Hypertrophic Pulmonary Osteoarthropathy	Hypertrophic Pulmonary Osteoarthropathy
Marie Bamberger Disease

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Congenital Anomaly Of Heart
Heart Defect	Heart Malformation
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Acromegaloid Changes, Cutis Verticis Gyrata, And Corneal Leukoma

Pachydermoperiostosis	Rosenthal-Kloepfer Syndrome
Pdp	Acromegaloid Changes, Cutis Verticis Gyrata And Corneal Leukoma
Idiopathic Hypertrophic Osteoarthropathy	Primary Hypertrophic Osteoarthropathy
Touraine Solente Gole Syndrome	Touraine-Solente-Gole Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-108259	HQL-79	Inhibitor	99.89%	否
HY-110167	TFC 007	Inhibitor	98.01%	否
HY-12791	hPGDS-IN-1	Inhibitor	99.92%	否
HY-10439	HPGDS inhibitor 1	Inhibitor	99.04%	否
HY-109134	Pizuglanstat	Inhibitor	99.70%	否
HY-139972	PROTAC(H-PGDS)-7		99.42%	否
HY-126134	HPGDS inhibitor 2	Inhibitor	99.72%	否
HY-146662	HPGDS inhibitor 3	Inhibitor	/	否
HY-157577	PROTAC(H-PGDS)-8	Degrader	/	否
HY-RS06338	HPGD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06339	Hpgd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06340	Hpgd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06341	HPGDS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-109134A	Pizuglanstat hydrate	Inhibitor	/	否
HY-120581	ML388	Inhibitor	/	否
HY-139171	F092	Inhibitor	99.79%	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	HPGD	VGNC	VGNC:56973
Macaca mulatta	HPGD	VGNC	VGNC:73512
Felis catus	HPGD	VGNC	VGNC:67638
Canis familiaris	HPGD	VGNC	VGNC:49605
Mus musculus	HPGD	MGD	MGI:108085
Rattus norvegicus	HPGD	RGD	RGD:620087
Others	HPGD	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HPGD - 15-hydroxyprostaglandin dehydrogenase Gene

关于 HPGD

功能概要

HPGD 基因产物(8)

HPGD 蛋白结构

重组 HPGD 蛋白

关联疾病

直系同源

热门区域

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HPGD - 15-hydroxyprostaglandin dehydrogenase Gene

关于 HPGD

功能概要

HPGD 基因产物(8)

HPGD 蛋白结构

重组 HPGD 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z