1. Gene
  2. ID3 - inhibitor of DNA binding 3 Gene

ID3 - inhibitor of DNA binding 3 Gene

中文名称:DNA 结合抑制因子 3

种属: Homo sapiens

同用名: HEIR-1; bHLHb25

基因 ID: 3399 | 基因类型: protein coding

关于 ID3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:23,557,926-23,559,501 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 199 orthologues, 3 paralogues and is associated with 33 phenotypes. Broad expression in thyroid (RPKM 81.9), prostate (RPKM 51.6) and 21 other tissues.

功能概要

该基因编码的蛋白质是一种螺旋-环-螺旋 (HLH) 蛋白,可与其他 HLH 蛋白形成异二聚体。然而,编码的蛋白质缺乏基本的 DNA 结合结构域,因此会抑制与其相互作用的任何 HLH 蛋白质的 DNA 结合。[RefSeq 提供,2011 年 8 月]

The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with Other HLH proteins. However, the encoded protein lacks a basic DNA-binding domain and therefore inhibits the DNA binding of any HLH protein with which it interacts. [provided by RefSeq, Aug 2011]

ID3 基因产物(1)

mRNA Protein Name
NM_002167.5 NP_002158.3 DNA-binding protein inhibitor ID-3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18255255 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
14627819 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
14627819 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ID3 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (42 - 81)

  • 0
  • 100
  • 119 a.a.
蛋白主名 其他名称

DNA-binding protein inhibitor ID-3

ID-like protein inhibitor HLH 1R21

ID3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ID3 Q02535 CREB5 Homo sapiens Q02930-3 32296183
种属内
ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3 25416956
种属内
ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3 25416956
种属内
ID3 Q02535 FAM74A1 Homo sapiens Q5RGS3 25416956
种属内
ID3 Q02535 RAB7A Homo sapiens P51149 32814053
种属内
ID3 Q02535 RAB7A Homo sapiens P51149 32814053
种属内
ID3 Q02535 RAB7A Homo sapiens P51149 32814053
种属内
ID3 Q02535 DMWD Homo sapiens G5E9A7 32814053
种属内
ID3 Q02535 DMWD Homo sapiens G5E9A7 32814053
种属内
ID3 Q02535 DMWD Homo sapiens G5E9A7 32814053
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081-3 32296183
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081-3 32296183
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081-3 31515488
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081-3 32296183
种属内
ID3 Q02535 ANKS1A Homo sapiens Q49AR9 32296183
种属内
ID3 Q02535 GUCD1 Homo sapiens Q96NT3-2 32296183
种属内
ID3 Q02535 TCF3 Homo sapiens P15923-3 32296183
种属内
ID3 Q02535 TCF3 Homo sapiens P15923-3 32296183
种属内
ID3 Q02535 TCF4 Homo sapiens P15884-3 32296183
种属内
ID3 Q02535 TCF4 Homo sapiens P15884-3 32296183
种属内
ID3 Q02535 MYF5 Homo sapiens P13349 32296183
种属内
ID3 Q02535 MYF5 Homo sapiens P13349 32296183
种属内
ID3 Q02535 KRTAP26-1 Homo sapiens Q6PEX3 32296183
种属内
ID3 Q02535 KAT5 Homo sapiens Q92993 32296183
种属内
ID3 Q02535 SPRED1 Homo sapiens Q7Z699 32814053
种属内
ID3 Q02535 SPRED1 Homo sapiens Q7Z699 32814053
种属内
ID3 Q02535 SPRED1 Homo sapiens Q7Z699 32814053
种属内
ID3 Q02535 TCF4 Homo sapiens P15884 25416956
种属内
ID3 Q02535 FHL2 Homo sapiens Q14192
Y2H
18255255
种属内
ID3 Q02535 FHL2 Homo sapiens Q14192 32296183
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081 31515488
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081 25416956
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081 25416956
种属内
ID3 Q02535 TCF12 Homo sapiens Q99081 20211142
种属内
ID3 Q02535 C22orf39 Homo sapiens Q6P5X5 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia

Acute T Cell Leukemia

Precursor T Lymphoblastic Leukemia

Precursor T-Lymphoblastic Lymphoma/Leukemia

T Acute Lymphoblastic Leukemia

T-Cell Acute Lymphocytic Leukaemia

T-Cell Lymphoblastic Leukemia/Lymphoma

Leukemia T-Cell

Leukemia, T-Cell

Leukemia, Acute, Lymphoblastic, T-Cell

Leukemia, T-Cell Acute Lymphoblastic

Leukemia, Acute T-Cell

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma

Precursor T-Cell Lymphoblastic Lymphoma

Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ID3 VGNC VGNC:41862
Bos taurus ID3 VGNC VGNC:30032
Macaca mulatta ID3 VGNC VGNC:99974
Rattus norvegicus ID3 RGD RGD:2860
Felis catus ID3 VGNC VGNC:107562
Mus musculus ID3 MGD MGI:96398
Others ID3 NCBI