2. Gene
  3. STRA8 - stimulated by retinoic acid 8 Gene

STRA8 - stimulated by retinoic acid 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：视黄酸刺激 8

种属: Homo sapiens

基因 ID: 346673 | 基因类型: protein coding

关于 STRA8

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,231,915-135,258,663 (from NCBI)

This gene has 3 transcripts (splice variants) and 133 orthologues. Low expression observed in reference dataset.

功能概要

该基因编码视黄酸反应蛋白。小鼠中的一种同源蛋白已被证明参与了精子发生和卵子发生中减数分裂起始的调节，尽管小鼠和人类蛋白质之间的特征差异表明这些同源物在功能上并不完全相同。据认为，该基因可能在人类精子发生中发挥作用。[RefSeq 提供，2010 年 11 月]

This gene encodes a retinoic acid-responsive protein. A homologous protein in mouse has been shown to be involved in the regulation of meiotic initiation in both spermatogenesis and oogenesis, though feature differences between the mouse and human proteins suggest that these homologs are not entirely functionally equivalent. It is thought that this gene may play a role in spermatogenesis in humans. [provided by RefSeq, Nov 2010]

STRA8 基因产物(2)

mRNA Protein Name
NM_001394401.1 NP_001381330.1 stimulated by retinoic acid gene 8 protein homolog isoform 1
NM_182489.3 NP_872295.2 stimulated by retinoic acid gene 8 protein homolog isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
22899867 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

stimulated by retinoic acid gene 8 protein homolog

STRA8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Validated Y2H
32296183
Intra STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Y2H Array
32296183
Intra STRA8 Q7Z7C7 TFIP11 Homo sapiens Q9UBB9
Y2H Prey Pooling
32296183
Intra STRA8 Q7Z7C7 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra STRA8 Q7Z7C7 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra STRA8 Q7Z7C7 POU6F2 Homo sapiens P78424
Y2H Array
32296183
Intra STRA8 Q7Z7C7 POU6F2 Homo sapiens P78424
Y2H Prey Pooling
32296183
Intra STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
Intra STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
Intra STRA8 Q7Z7C7 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
Intra STRA8 Q7Z7C7 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra STRA8 Q7Z7C7 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra STRA8 Q7Z7C7 ANKRD11 Homo sapiens X5D778
Validated Y2H
32296183
Intra STRA8 Q7Z7C7 SERTAD2 Homo sapiens Q14140
Y2H Array
32296183
Intra STRA8 Q7Z7C7 SERTAD2 Homo sapiens Q14140
Y2H Prey Pooling
32296183
Intra STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Validated Y2H
32296183
Intra STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Y2H Array
32296183
Intra STRA8 Q7Z7C7 CTDSP1 Homo sapiens Q9GZU7
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spastic Paraplegia 24, Autosomal Recessive

SPG24

Spastic Paraplegia 24

Hereditary Spastic Paraplegia 24

Autosomal Recessive Spastic Paraplegia Type 24

Autosomal Recessive Spastic Paraplegia 24
Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome

Germinal Cell Aplasia

Del Castillo Syndrome

SPGFX1

X-Linked Spermatogenic Failure 1

Congenital Absence Of Germinal Epithelium Of Testes
Hereditary Spastic Paraplegia 56

Autosomal Recessive Spastic Paraplegia Type 56

Spg56

Autosomal Recessive Spastic Paraplegia 56
Spermatocytoma

Spermatocytic Seminoma
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos
Testicular Disease

Testicular Dysfunction

Testicular Diseases

Disorder Of Testis

Testis Disorder

Testicular Disorders
Testicular Germ Cell Cancer

Germ Cell Tumor Of Testis

Testicular Germ Cell Tumor

Testicular Germ Cell Neoplasm

Testicular Malignant Germ Cell Tumor
Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Testicular Cancer

Testis Cancer

Testicular Carcinoma

Testicular Neoplasms

Malignant Neoplasm Of Testis

Childhood Neoplasm Of The Testis

Neoplasm Of Testis

Pediatric Testicular Neoplasm

Testicular Tumor

Testis Neoplasm

Testicular Tumors

Testicular Neoplasm

Testicular Malignant Germ Cell Tumor

Childhood Testicular Neoplasm

Carcinoma Of The Testis

Cancer Of Testis

Malignant Neoplasm Of Testis, Nos

Malignant Neoplasm Of Testis, Unspecified

Malignant Tumour Of Testis

Testicle Cancer

Primary Malignant Neoplasm Of Testis
Disorder Of Sexual Development

Disorder Of Sex Development

Disorders Of Sex Development

Sex Development Disorder

Sex Differentiation Disease

Dsd

Sex Differentiation Disorders
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W011094 Win 18446 Inhibitor 98.57% 否
HY-RS13958 STRA8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus STRA8 VGNC VGNC:65800
Rattus norvegicus STRA8 RGD RGD:1562852
Bos taurus STRA8 VGNC VGNC:53678
Canis familiaris STRA8 VGNC VGNC:46938
Mus musculus STRA8 MGD MGI:107917
Macaca mulatta STRA8 VGNC VGNC:78250
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