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  2. RAB41 - RAB41, member RAS oncogene family Gene

RAB41 - RAB41, member RAS oncogene family Gene

中文名称:RAB41,RAS 致癌基因家族成员

种属: Homo sapiens

基因 ID: 347517 | 基因类型: protein coding

关于 RAB41

This gene has 3 transcripts (splice variants), 69 orthologues and 68 paralogues. Low expression observed in reference dataset.

功能概要

该基因编码一种小的 GTP 结合蛋白,属于 Ras 超家族中最大的家族。这些蛋白质充当膜运输的调节剂。它们在非活性 GDP 结合状态和激活的 GTP 结合状态之间循环,这由 GTP 水解激活蛋白 (GAP) 控制。该家族成员可被 GAP 蛋白 RN-Tre 激活,并定位于高尔基复合体。[RefSeq 提供,2010 年 5 月]

This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]

RAB41 基因产物(2)

mRNA Protein Name
NM_001032726.3 NP_001027898.2 ras-related protein Rab-41 isoform 1
NM_001363807.1 NP_001350736.1 ras-related protein Rab-41 isoform 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RAB41 蛋白结构

Ras

Ras: Ras family (33 - 192)

  • 0
  • 100
  • 200
  • 222 a.a.
蛋白主名 其他名称

ras-related protein Rab-41

RAB41, member RAS homolog family

RAB41 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RAB41 Q5JT25 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
种属内
RAB41 Q5JT25 REL Homo sapiens Q04864
Y2H Array
25416956
种属内
RAB41 Q5JT25 TCF4 Homo sapiens P15884
Y2H Prey Pooling
25416956
种属内
RAB41 Q5JT25 TCF4 Homo sapiens P15884
Validated Y2H
25416956
种属内
RAB41 Q5JT25 PPP5C Homo sapiens P53041
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Microvillus Inclusion Disease

Congenital Microvillous Atrophy

Intractable Diarrhea Of Infancy

Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities

Davidson Disease

Microvillous Inclusion Disease

Congenital Microvillus Atrophy

Mvid

Diarrhea 2 With Microvillus Atrophy

Mvd

Congenital Familial Protracted Diarrhea

Davidson'S Disease

Familial Enteropathy, Microvillus

Microvillus Atrophy, Congenital

Congenital Enteropathy

Familial Protracted Enteropathy

Microvillous Atrophy

Microvillus Atrophy With Diarrhea 2

Idi

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma