2. Gene
  3. SLC35B2 - solute carrier family 35 member B2 Gene

SLC35B2 - solute carrier family 35 member B2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 35 成员 B2

种属: Homo sapiens

同用名: SLL; PAPST1; UGTrel4

基因 ID: 347734 | 基因类型: protein coding

关于 SLC35B2

Cytogenetic location: 6p21.1 Genomic coordinates (GRCh38): 6:44,254,101-44,257,890 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 3 paralogues. Ubiquitous expression in gall bladder (RPKM 17.2), thyroid (RPKM 15.1) and 25 other tissues.

功能概要

磺基转移酶 (例如，SULT4A1；MIM 608359) 使用硫酸盐的活化形式，3-磷酸腺苷 5-磷酸磷酸盐 (PAPS) ，作为内质网和高尔基体中糖蛋白、蛋白多糖和糖脂硫酸化的常见硫酸盐供体仪器。 SLC35B2 位于微粒体膜中，将 PAPS 从合成它的胞质溶胶转运到高尔基体腔中 (Kamiyama 等人，2003 [PubMed 12716889]) 。[OMIM 提供，2008 年 3 月]

Sulfotransferases (e.g., SULT4A1; MIM 608359) use an activated form of sulfate, 3-prime-phosphoadenosine 5-prime-phosphosulfate (PAPS), as a common sulfate donor for sulfation of glycoproteins, proteoglycans, and glycolipids in the endoplasmic reticulum and Golgi apparatus. SLC35B2 is located in the microsomal membrane and transports PAPS from the cytosol, where it is synthesized, into the Golgi lumen (Kamiyama et al., 2003 [PubMed 12716889]).[supplied by OMIM, Mar 2008]

SLC35B2 基因产物(9)

mRNA Protein Name
NM_001286509.2 NP_001273438.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286510.2 NP_001273439.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform b
NM_001286511.2 NP_001273440.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286512.2 NP_001273441.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform c
NM_001286513.2 NP_001273442.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform d precursor
NM_001286517.2 NP_001273446.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform e
NM_001286519.2 NP_001273448.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_001286520.2 NP_001273449.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform f
NM_178148.4 NP_835361.1 adenosine 3'-phospho 5'-phosphosulfate transporter 1 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity IDA
IDA: 通过直接分析推断
12716889 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in 3'-phosphoadenosine 5'-phosphosulfate transport IDA
IDA: 通过直接分析推断
12716889 GOA
involved in chondroitin sulfate biosynthetic process IMP
IMP: 通过突变表型推断
35325049 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
12716889 GOA
located in Golgi membrane IDA
IDA: 通过直接分析推断
12716889 GOA
located in membrane IDA
IDA: 通过直接分析推断
12716889 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC35B2 蛋白结构

UAA

UAA: UAA transporter family (112 - 413)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
蛋白主名 其他名称

adenosine 3'-phospho 5'-phosphosulfate transporter 1

3'-phosphoadenosine 5'-phosphosulfate transporter

SLC35B2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC35B2 Q8TB61 TMEM248 Homo sapiens Q9NWD8
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 TMEM248 Homo sapiens Q9NWD8
Validated Y2H
32296183
种属内
SLC35B2 Q8TB61 TMEM248 Homo sapiens Q9NWD8
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 CYB5R3 Homo sapiens P00387
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 CYB5R3 Homo sapiens P00387
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
种属内
SLC35B2 Q8TB61 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 RNF170 Homo sapiens Q96K19-5
Validated Y2H
32296183
种属内
SLC35B2 Q8TB61 RNF170 Homo sapiens Q96K19-5
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 RNF170 Homo sapiens Q96K19-5
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 ASGR2 Homo sapiens P07307-3
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 ASGR2 Homo sapiens P07307-3
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 CLDN15 Homo sapiens Q96FX9
Validated Y2H
32296183
种属内
SLC35B2 Q8TB61 CLDN15 Homo sapiens Q96FX9
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 CLDN15 Homo sapiens Q96FX9
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 AQP6 Homo sapiens Q13520
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 TEX29 Homo sapiens Q8N6K0
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 TEX29 Homo sapiens Q8N6K0
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 CD69 Homo sapiens Q07108
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 CD69 Homo sapiens Q07108
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
种属内
SLC35B2 Q8TB61 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 GOLM1 Homo sapiens Q8NBJ4
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 GOLM1 Homo sapiens Q8NBJ4
Y2H Prey Pooling
32296183
种属内
SLC35B2 Q8TB61 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
种属内
SLC35B2 Q8TB61 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
种属内
SLC35B2 Q8TB61 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Primary Bone Dysplasia With Multiple Joint Dislocations

Primary Osteodysplasia With Multiple Joint Dislocations

Primary Skeletal Dysplasia With Multiple Joint Dislocations
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13199 SLC35B2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SLC35B2 VGNC VGNC:46365
Rattus norvegicus SLC35B2 RGD RGD:1565318
Felis catus SLC35B2 VGNC VGNC:102518
Mus musculus SLC35B2 MGD MGI:1921086
Bos taurus SLC35B2 VGNC VGNC:34824
Macaca mulatta SLC35B2 VGNC VGNC:83469
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