FOXK2 - forkhead box K2 Gene

中文名称：叉头盒 K2

种属: Homo sapiens

同用名: ILF; ILF1; ILF-1; nGTBP

基因 ID: 3607 | 基因类型: protein coding

关于 FOXK2

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,519,732-82,604,602 (from NCBI)

This gene has 12 transcripts (splice variants), 273 orthologues and 42 paralogues. Ubiquitous expression in testis (RPKM 11.2), brain (RPKM 8.3) and 25 other tissues.

功能概要

该基因编码的蛋白质含有一个叉头 DNA 结合结构域。这种蛋白质可以与 HIV 长末端重复序列 (LTR) 中富含嘌呤的基序结合，也可以与白细胞介素 2 (IL2) 启动子中类似的富含嘌呤基序结合。它可能参与病毒和细胞启动子元件的调节。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements. [provided by RefSeq, Jul 2008]

FOXK2 基因产物(1)

mRNA	Protein	Name
NM_004514.4	NP_004505.2	forkhead box protein K2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	9065434	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: 通过直接分析推断	9065434	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	16624804	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21903422	GOA
enables sequence-specific DNA binding	IDA IDA: 通过直接分析推断	1339390	GOA
enables transcription cis-regulatory region binding	IDA IDA: 通过直接分析推断	22083952	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	20810654	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	22083952	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9065434	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in nucleus	IDA IDA: 通过直接分析推断	20810654	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXK2 蛋白结构

FHA

Forkhead

0
200
400
600
660 a.a.

蛋白主名

其他名称

forkhead box protein K2

FOXK1

FOXK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	FOXK2	Q01167	IRF2	Homo sapiens	P14316	Anti Tag CoIP	21903422
种属内	FOXK2	Q01167	IRF2	Homo sapiens	P14316	TAP	25609649
种属内	FOXK2	Q01167	MAX	Homo sapiens	P61244	TAP	25609649

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Bainbridge-Ropers Syndrome

BRPS	Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome
Asxl3-Related Disorder

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS05060	FOXK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	FOXK2	MGD	MGI:1916087
Bos taurus	FOXK2	VGNC	VGNC:55831
Felis catus	FOXK2	VGNC	VGNC:67789
Macaca mulatta	FOXK2	VGNC	VGNC:72711
Canis familiaris	FOXK2	VGNC	VGNC:84864
Rattus norvegicus	FOXK2	RGD	RGD:1305408

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FOXK2 - forkhead box K2 Gene

关于 FOXK2

功能概要

FOXK2 基因产物(1)

FOXK2 蛋白结构

FOXK2 蛋白互作信息

关联疾病

直系同源

热门区域

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FOXK2 - forkhead box K2 Gene

关于 FOXK2

功能概要

FOXK2 基因产物(1)

FOXK2 蛋白结构

FOXK2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z