1. Gene
  2. IRF2 - interferon regulatory factor 2 Gene

IRF2 - interferon regulatory factor 2 Gene

中文名称:干扰素调节因子 2

种属: Homo sapiens

同用名: IRF-2

基因 ID: 3660 | 基因类型: protein coding

关于 IRF2

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:184,387,729-184,474,550 (from NCBI)

This gene has 23 transcripts (splice variants), 231 orthologues and 8 paralogues. Ubiquitous expression in spleen (RPKM 28.3), lymph node (RPKM 28.2) and 25 other tissues.

功能概要

IRF2 编码干扰素调节因子 2,是干扰素调节转录因子 (IRF) 家族的成员。 IRF2 竞争性地抑制 IRF1 介导的干扰素 alpha 和 beta 的转录激活,以及可能使用 IRF1 进行转录激活的其他基因。然而,IRF2 也作为组蛋白 H4 的转录激活因子发挥作用。[RefSeq 提供,2008 年 7 月]

IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably Other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. [provided by RefSeq, Jul 2008]

IRF2 基因产物(1)

mRNA Protein Name
NM_002199.4 NP_002190.2 interferon regulatory factor 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9540062 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
IMP: 通过突变表型推断
9540062 GOA
enables DNA-binding transcription factor activity IMP
IMP: 通过突变表型推断
9540062 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
9540062 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
9540062 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to virus IDA
IDA: 通过直接分析推断
21478870 GOA
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
9540062 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
9540062 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

IRF2 蛋白结构

IRF

IRF: Interferon regulatory factor transcription factor (5 - 113)

  • 0
  • 100
  • 200
  • 300
  • 349 a.a.
蛋白主名 其他名称

interferon regulatory factor 2

IRF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
IRF2 P14316 PPP3CB Homo sapiens P16298
Anti Tag CoIP
21903422
种属内
IRF2 P14316 FOXK1 Homo sapiens P85037
Anti Tag CoIP
33961781
种属内
IRF2 P14316 FOXK1 Homo sapiens P85037
Anti Tag CoIP
28514442
种属内
IRF2 P14316 FOXK1 Homo sapiens P85037
Anti Tag CoIP
21903422
种属内
IRF2 P14316 FOXK2 Homo sapiens Q01167
Anti Tag CoIP
33961781
种属内
IRF2 P14316 FOXK2 Homo sapiens Q01167
Anti Tag CoIP
28514442
种属内
IRF2 P14316 FOXK2 Homo sapiens Q01167
Anti Tag CoIP
21903422
种属内
IRF2 P14316 TASOR2 Homo sapiens Q5VWN6
Anti Tag CoIP
33961781
种属内
IRF2 P14316 TASOR2 Homo sapiens Q5VWN6
Anti Tag CoIP
28514442
种属内
IRF2 P14316 ATG7 Homo sapiens O95352
Anti Tag CoIP
21903422
种属间: 跨种属相互作用 种属内: 同种属相互作用

IRF2 抗体

目录号 产品名 应用 反应物种
HY-P83385 IRF2 Antibody (YA3130) WB, IHC-P, ICC/IF Human, Mouse

关联疾病

疾病名称 别名
Embryonal Testis Carcinoma

Testicular Embryonal Carcinoma

Embryonal Carcinoma Of Testis

Embryonal Carcinoma Of The Testis

Psoriasis
Viral Infectious Disease

Viral Disease

Arbovirus Infections

Virus Infection

Virus Diseases

Viral Infection

Viral Infections

Virus Infections

Skin Disease

Skin Diseases

Genodermatosis

Abnormality Of The Skin

Skin Diseases, Genetic

Skin And Subcutaneous Tissue Disease

Dermatologic Disorders

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta IRF2 VGNC VGNC:73760
Mus musculus IRF2 MGD MGI:96591
Canis familiaris IRF2 VGNC VGNC:42092
Bos taurus IRF2 VGNC VGNC:30271
Felis catus IRF2 VGNC VGNC:67823
Rattus norvegicus IRF2 RGD RGD:1304922