1. Gene
  2. INSRR - insulin receptor related receptor Gene

INSRR - insulin receptor related receptor Gene

中文名称:胰岛素受体相关受体

种属: Homo sapiens

同用名: IRR

基因 ID: 3645 | 基因类型: protein coding

关于 INSRR

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,840,063-156,859,117 (from NCBI)

This gene has 1 transcript (splice variant), 124 orthologues and 53 paralogues. Biased expression in kidney (RPKM 1.2), testis (RPKM 1.1) and 5 other tissues.

功能概要

启用跨膜受体蛋白酪氨酸激酶活性。参与肌动蛋白细胞骨架重组;细胞对碱性 pH 值的反应;和蛋白质自身磷酸化。受体复合体的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables transmembrane receptor protein tyrosine kinase activity. Involved in actin Cytoskeleton reorganization; cellular response to alkaline pH; and protein autophosphorylation. Part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

INSRR 基因产物(1)

mRNA Protein Name
NM_014215.3 NP_055030.1 insulin receptor-related protein precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
21641549 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in actin cytoskeleton organization IDA
IDA: 通过直接分析推断
21641549 GOA
involved in cellular response to alkaline pH IDA
IDA: 通过直接分析推断
21641549 GOA
involved in protein autophosphorylation IMP
IMP: 通过突变表型推断
21641549 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of receptor complex IDA
IDA: 通过直接分析推断
23382219 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

INSRR 蛋白结构

Recep_L_domain

Recep_L_domain: Receptor L domain (47 - 157)

Furin-like

Furin-like: Furin-like cysteine rich region (175 - 329)

Recep_L_domain

Recep_L_domain: Receptor L domain (346 - 454)

fn3

fn3: Fibronectin type III domain (819 - 901)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (980 - 1244)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1200
  • 1297 a.a.
蛋白主名 其他名称

insulin receptor-related protein

IR-related receptor

INSRR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
INSRR P14616 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
种属内
INSRR P14616 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
种属内
INSRR P14616 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
种属内
INSRR P14616 HSP90AB1 Homo sapiens P08238
Affinity Chrom
35384245
种属内
INSRR P14616 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
种属内
INSRR P14616 HSP90AB1 Homo sapiens P08238
BioID
35384245
种属内
INSRR P14616 INSR Homo sapiens P06213
Anti Tag CoIP
33961781
种属内
INSRR P14616 INSR Homo sapiens P06213
BioID
35384245
种属内
INSRR P14616 INSR Homo sapiens P06213
Affinity Chrom
35384245
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Rickettsialpox

Vesicular Rickettsiosis

Rickettsia Akari Spotted Fever

Doid:11103

Rickettsiaceae Infections

Kew Gardens Spotted Fever

Rickettsia Akari Smallpox

Rickettsia Akari Infection

Regular Astigmatism
Cone-Rod Dystrophy 12

CORD12

Dystrophy, Cone-Rod, Type 12

Familial Atrial Fibrillation

Atrial Fibrillation, Familial

Atfb

Atrial Fibrillation Autosomal Dominant

Autosomal Dominant Atrial Fibrillation

Auricular Fibrillation

Atrial Fibrillation

Atrial Fibrillation, Familial, 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris INSRR VGNC VGNC:42044
Rattus norvegicus INSRR RGD RGD:67399
Bos taurus INSRR VGNC VGNC:30222
Felis catus INSRR VGNC VGNC:67812
Mus musculus INSRR MGD MGI:1346037
Macaca mulatta INSRR VGNC VGNC:106390