RHOG - ras homolog family member G Gene

中文名称：ras 同系物家族成员 G

种属: Homo sapiens

同用名: ARHG

基因 ID: 391 | 基因类型: protein coding

关于 RHOG

Cytogenetic location: 11p15.4 Genomic coordinates (GRCh38): 11:3,826,978-3,840,959 (from NCBI)

This gene has 4 transcripts (splice variants), 248 orthologues and 22 paralogues. Broad expression in bone marrow (RPKM 74.8), spleen (RPKM 41.3) and 24 other tissues.

功能概要

该基因编码小 GTP 酶 Rho 家族的一个成员，它在非活性 GDP 结合状态和活性 GTP 结合状态之间循环，并在信号转导级联中充当分子开关。 Rho 蛋白促进肌动蛋白细胞骨架的重组并调节细胞形状、附着和运动。编码的蛋白质促进功能性鸟嘌呤核苷酸交换因子 (GEF) 复合物从细胞质易位到质膜，在质膜中 Ras 相关的 C3 肉毒杆菌毒素底物 1 被激活以促进 lamellipodium 形成和细胞迁移。已在 20 号和 X 号染色体上鉴定出两个相关的假基因。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]

RHOG 基因产物(1)

mRNA	Protein	Name
NM_001665.4	NP_001656.2	rho-related GTP-binding protein RhoG

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GTPase activity	IDA IDA: 通过直接分析推断	12376551	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12879077	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within Rac protein signal transduction	IDA IDA: 通过直接分析推断	12376551	GOA
acts upstream of or within Rho protein signal transduction	IDA IDA: 通过直接分析推断	12376551	GOA
acts upstream of or within actin cytoskeleton organization	IDA IDA: 通过直接分析推断	12545154	GOA
involved in activation of GTPase activity	IMP IMP: 通过突变表型推断	20679435	GOA
involved in cell chemotaxis	IMP IMP: 通过突变表型推断	20679435	GOA
acts upstream of or within positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	12545154	GOA
involved in positive regulation of protein localization to plasma membrane	IMP IMP: 通过突变表型推断	20679435	GOA
involved in regulation of postsynapse assembly	IDA IDA: 通过直接分析推断	21900250	GOA
involved in regulation of postsynapse assembly	IMP IMP: 通过突变表型推断	21900250	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	21900250	GOA
is active in glutamatergic synapse	IMP IMP: 通过突变表型推断	21900250	GOA
is active in postsynapse	IDA IDA: 通过直接分析推断	21900250	GOA
is active in postsynapse	IMP IMP: 通过突变表型推断	21900250	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RHOG 蛋白结构

Ras

0
100
191 a.a.

蛋白主名

其他名称

rho-related GTP-binding protein RhoG

ras homolog gene family, member G (rho G)

RHOG 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RHOG	P84095	UNC13D	Homo sapiens	Q70J99	Pull Down	33513601
种属内	RHOG	P84095	ELMO1	Homo sapiens	Q92556	Anti Tag CoIP	12879077
种属内	RHOG	P84095	ELMO1	Homo sapiens	Q92556	Pull Down	33513601
种属内	RHOG	P84095	ELMO1	Homo sapiens	Q92556	Pull Down	12879077

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Immunodeficiency 73a With Defective Neutrophil Chemotaxis And Leukocytosis

Neutrophil Immunodeficiency Syndrome	IMD73A
Immunodeficiency 73a With Defective Neutrophil Chemotaxix And Leukocytosis	Immunodeficiency, Type 73a, With Defective Neutrophil Chemotaxix And Leukocytosis
Rac 2 Deficiency

Tangier Disease

Analphalipoproteinemia	High Density Lipoprotein Deficiency, Tangier Type
TGD	High Density Lipoprotein Deficiency, Type 1
Hdldt1	Familial High Density Lipoprotein Deficiency
A-Alphalipoprotein Neuropathy	Alpha High Density Lipoprotein Deficiency Disease
Cholesterol Thesaurismosis	Familial High Density Lipoprotein Deficiency Disease
Hdl Lipoprotein Deficiency Disease	Tangier Disease Neuropathy
Familial Alpha-Lipoprotein Deficiency	Familial High-Density Lipoprotein Deficiency 1
Primary Hypoalphalipoproteinemia 1	Analphalipo-Proteinemia
Familial Hypoalphalipo-Proteinemia	Familial Hypoalphalipoproteinemia
Lipoprotein Deficiency Disease, Hdl, Familial	Tangier Hereditary Neuropathy
Atp-Binding Cassette Transporter A1 Deficiency	Hdld1
High Density Lipoprotein Deficiency 1	Tangier Disease, Variant
Hypoalphalipoproteinemia, Familial	Familial Hdl Deficiency

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS11953	RHOG Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	RHOG	VGNC	VGNC:101390
Bos taurus	RHOG	VGNC	VGNC:33949
Mus musculus	RHOG	MGD	MGI:1928370
Rattus norvegicus	RHOG	RGD	RGD:621310
Canis familiaris	RHOG	VGNC	VGNC:45560
Felis catus	RHOG	VGNC	VGNC:68107

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RHOG - ras homolog family member G Gene

关于 RHOG

功能概要

RHOG 基因产物(1)

RHOG 蛋白结构

RHOG 蛋白互作信息

关联疾病

直系同源

热门区域

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RHOG - ras homolog family member G Gene

关于 RHOG

功能概要

RHOG 基因产物(1)

RHOG 蛋白结构

RHOG 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z