RPSA - ribosomal protein SA Gene

中文名称：核糖体蛋白

种属: Homo sapiens

同用名: SA; LBP; LRP; p40; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4

基因 ID: 3921 | 基因类型: protein coding

关于 RPSA

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:39,406,720-39,412,542 (from NCBI)

This gene has 20 transcripts (splice variants), 211 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 792.7), lymph node (RPKM 583.0) and 25 other tissues.

功能概要

层粘连蛋白是细胞外基质糖蛋白家族，是基底膜的主要非胶原成分。它们涉及多种生物过程，包括细胞粘附、分化、迁移、信号传导、神经突生长和转移。层粘连蛋白的许多作用是通过与细胞表面受体的相互作用介导的。这些受体包括整合素家族的成员，以及非整合素层粘连蛋白结合蛋白。该基因编码高亲和力、非整联蛋白家族层粘连蛋白受体 1。该受体被称为 67 kD 层粘连蛋白受体、37 kD 层粘连蛋白受体前体 (37LRP) 和 p40 核糖体相关蛋白。层粘连蛋白受体 1 的氨基酸序列在进化过程中高度保守，表明其具有关键的生物学功能。已经观察到层粘连蛋白受体转录物的水平在结肠癌组织和肺癌细胞系中高于它们的正常对应物。此外，该多肽在癌细胞中的上调与其侵袭性和转移性表型之间存在相关性。存在该基因的多个拷贝，但是，它们中的大多数是假基因，被认为是由逆位事件引起的。已经为该基因发现了编码相同蛋白质的两个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the Integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung Cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in Cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RPSA 基因产物(2)

mRNA	Protein	Name
NM_001304288.2	NP_001291217.1	40S ribosomal protein SA isoform 2
NM_002295.6	NP_002286.2	40S ribosomal protein SA isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA binding	IDA IDA: 通过直接分析推断	38114488	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16169070	GOA
enables ribosome binding	IPI IPI: 通过物理相互作用推断	10079194	GOA
enables structural constituent of ribosome	IDA IDA: 通过直接分析推断	23636399	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in antiviral innate immune response	IDA IDA: 通过直接分析推断	38114488	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16263087	GOA
located in cytosolic ribosome	IDA IDA: 通过直接分析推断	23636399	GOA
part of cytosolic small ribosomal subunit	IDA IDA: 通过直接分析推断	8706699	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	38114488	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	16263087	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RPSA 蛋白结构

Ribosomal_S2

0
100
200
295 a.a.

蛋白主名

其他名称

40S ribosomal protein SA

37 kDa laminin receptor

RPSA 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	RPSA	P08865	CCDC13	Homo sapiens	Q8IYE1	Validated Y2H	32296183
种属内	RPSA	P08865	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	RPSA	P08865	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	RPSA	P08865	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	RPSA	P08865	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	RPSA	P08865	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	RPSA	P08865	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	RPSA	P08865	HSPB1	Homo sapiens	P04792	Reverse RRS	25277244
种属内	RPSA	P08865	KARS1	Homo sapiens	Q15046	Anti Tag CoIP	24212136
种属内	RPSA	P08865	KARS1	Homo sapiens	Q15046	Pull Down	24212136
种属内	RPSA	P08865	KARS1	Homo sapiens	Q15046	NMR	24983501
种属内	RPSA	P08865	KARS1	Homo sapiens	Q15046	GMS	24983501
种属内	RPSA	P08865	KARS1	Homo sapiens	Q15046	Y2H	24212136
种属内	RPSA	P08865	RPS21	Homo sapiens	P63220	Anti Tag CoIP	33961781
种属内	RPSA	P08865	RPS21	Homo sapiens	P63220	Anti Tag CoIP	28514442
种属内	RPSA	P08865	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950
种属内	RPSA	P08865	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
种属内	RPSA	P08865	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	RPSA	P08865	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	RPSA	P08865	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	RPSA	P08865	GAB2	Homo sapiens	Q9UQC2	Validated Y2H	32814053
种属内	RPSA	P08865	GAB2	Homo sapiens	Q9UQC2	Y2H Array	32814053
种属内	RPSA	P08865	GAB2	Homo sapiens	Q9UQC2	Y2H Pooling	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

RPSA 抗体

目录号	产品名	应用	反应物种
HY-P82214	67kDa Laminin Receptor Antibody (YA1959)	WB, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Asplenia, Isolated Congenital

ICAS	Splenic Hypoplasia
Familial Isolated Congenital Asplenia	Hyposplenia, Isolated Congenital
Asplenia, Familial	Isolated Congenital Asplenia
Congenital Hypoplasia Of Spleen	Hypoplasia Of Spleen
Spenlic Hypoplasia	Congenital Isolated Hyposplenia
Familial Asplenia

Venezuelan Equine Encephalitis

Venezuelan Equine Fever	Venezuelan Equine Encephalomyelitis
Encephalitis Venezuelan Equine	Encephalomyelitis, Venezuelan Equine
Venezuelan Encephalitis	Disorder Due To Venezuelan Equine Encephalitis Virus
Venezuelan Equine Encephalitis Virus Infection	Venezuelan Equine Encephalomyelitis Virus Disease

Encephalitis

Mumps Encephalitis	Mumps Meningoencephalitis
Herpes Simplex Neuroinvasion	Herpetic Encephalitis
Herpetic Encephalopathy	Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis
Encephalitis Due To Herpesviridae	Encephalitis Due To Herpesvirus
Herpes Encephalitis	Herpesviral Encephalitis
Herpes Simplex Encephalitis	Hsv - [Herpes Simplex Virus] Encephalitis
Herpes Virus Encephalitis	Simian B Disease
Simian B Disorder	Encephalitis Nec
Idiopathic Encephalitis

Dengue Virus

Dengue Virus, Susceptibility To	Dengue Fever, Protection Against
Dengue Fever

Tick-Borne Encephalitis

Siberian Tick-Borne Encephalitis	Encephalitis, Tick-Borne
Central European Encephalitis	Far Eastern Tbe
Russian Spring-Summer Encephalitis	Taiga Encephalitis
West-Siberian Encephalitis	Western European Tick-Borne Encephalitis
Tbe	Encephalitis Tick-Borne
Encephalitis, Central European	Encephalitis, Far Eastern Russian

Scrapie

Creutzfeldt-Jakob Disease

Variant Creutzfeldt-Jakob Disease	CJD
Bovine Spongiform Encephalopathy	Vcjd
Inherited Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Familial
Creutzfeldt Jakob Disease	Creutzfeldt-Jacob Disease
Creutzfeldt Jacob Disease	Sporadic Creutzfeldt-Jakob Disease
Encephalopathy, Bovine Spongiform	Creutzfeldt-Jakob Disease, Variant, Resistance To
Creutzfeldt-Jakob Disease, Variant	Creutzfeldt Jacob Syndrome
Jakob-Creutzfeldt Disease	Subacute Spongiform Encephalopathy
Transmissible Virus Dementia	New Variant Of Cjd
Nv-Cjd	Variant Cjd
Variant Creutzfeldt-Jacob Disease	Sporadic Cjd
Inherited Cjd	Acquired Creutzfeldt-Jakob Disease
Variant Mcj	Encephalopathy Bovine Spongiform
Familial Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Syndrome
New Variant Creutzfeldt-Jakob Disease	Creutzfeldt-Jakob Disease, Sporadic
Acquired Cjd	Scjd - [Sporadic Creutzfeldt-Jakob Disease]
Idiopathic Creutzfeldt-Jakob Disease	Creutzfeld-Jakob Disease Nos
Vcjd - [Variant Creutzfeldt-Jakob Disease]

Flying Phobia

Aerophobia

Prion Disease

Spongiform Encephalopathy	Transmissible Spongiform Encephalopathies
Prion Diseases	Prion Disease Pathway
Transmissible Spongiform Encephalopathy	Prion Induced Disorder
Prion Protein Disease	Inherited Human Transmissible Spongiform Encephalopathies
Prion Protein Diseases	Prion-Associated Disorders
Prion-Induced Disorders	Transmissible Dementias
Tses	Human Prion Disease
Tse	Encephalopathy, Transmissible Spongiform
Prion Disease, Susceptibility To	Spongiform Encephalopathies
Human Transmissible Spongiform Encephalopathies, Inherited

Chronic Wasting Disease

Wasting Disease, Chronic

Gummatous Syphilis

Early Congenital Syphilis

Oral Mucosa Leukoplakia

Leukoplakia, Oral

Leukoplakia Of Buccal Mucosa

Arrhythmogenic Right Ventricular Dysplasia, Familial, 9

Arrhythmogenic Right Ventricular Dysplasia 9	ARVD9
Arrhythmogenic Right Ventricular Cardiomyopathy 9	Arvc9
Familial Arrhythmogenic Right Ventricular Dysplasia 9	Dysplasia, Arrhythmogenic Right Ventricular, Type 9

Meningovascular Neurosyphilis

Primary Syphilis

Early Symptomatic Syphilis	Early Syphilis, Symptomatic
Symptomatic Early Syphilis

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Right Atrial Isomerism

Ivemark Syndrome	Asplenia With Cardiovascular Anomalies
RAI	Asplenia Syndrome
Asplenia	Right Isomerism
Splenic Agenesis Syndrome	Bilateral Right-Sidedness Sequence
Right Sided Atrial Isomerism	Isomerism Of Right Atrial Appendage
Heterotaxy, Visceroatrial, Autosomal Recessive	Polyasplenia
Vah, Autosomal Recessive	Atrial Isomerism, Right
Congenital Absence Of Spleen	Bilateral Right-Sidedness

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-146446	PXYC1	Inhibitor	98.98%	否
HY-146447	PXYC13	Inhibitor	/	否
HY-146448	PXYD3	Inhibitor	/	否
HY-146449	PXYD4	Inhibitor	/	否
HY-146450	PXYC2	Inhibitor	/	否
HY-146451	PXYC12	Inhibitor	/	否
HY-RS12272	RPSA Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	RPSA	VGNC	VGNC:50207
Mus musculus	RPSA	MGD	MGI:105381
Rattus norvegicus	RPSA	RGD	RGD:71026

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

RPSA - ribosomal protein SA Gene

关于 RPSA

功能概要

RPSA 基因产物(2)

RPSA 蛋白结构

RPSA 蛋白互作信息

RPSA 抗体

关联疾病

直系同源

热门区域

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RPSA - ribosomal protein SA Gene

关于 RPSA

功能概要

RPSA 基因产物(2)

RPSA 蛋白结构

RPSA 蛋白互作信息

RPSA 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z