1. Gene
  2. LTK - leukocyte receptor tyrosine kinase Gene

LTK - leukocyte receptor tyrosine kinase Gene

中文名称:白细胞受体酪氨酸激酶

种属: Homo sapiens

同用名: TYK1

基因 ID: 4058 | 基因类型: protein coding

关于 LTK

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:41,503,637-41,513,827 (from NCBI)

This gene has 6 transcripts (splice variants), 62 orthologues and 53 paralogues. Broad expression in duodenum (RPKM 6.4), lung (RPKM 6.1) and 15 other tissues.

功能概要

由该基因编码的蛋白质是酪氨酸激酶的 ros/胰岛素受体家族的成员。蛋白质的酪氨酸特异性磷酸化是控制导致细胞生长和分化的多种途径的关键。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供,2008 年 10 月]

The protein encoded by this gene is a member of the ros/Insulin Receptor family of tyrosine kinases. Tyrosine-specific phosphorylation of proteins is a key to the control of diverse pathways leading to cell growth and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

LTK 基因产物(3)

mRNA Protein Name
NM_001135685.2 NP_001129157.1 leukocyte tyrosine kinase receptor isoform 3 precursor
NM_002344.6 NP_002335.2 leukocyte tyrosine kinase receptor isoform 1 precursor
NM_206961.4 NP_996844.1 leukocyte tyrosine kinase receptor isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9223670 GOA
enables protein kinase activity IDA
IDA: 通过直接分析推断
10445845 GOA
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
7650032 GOA
enables receptor signaling protein tyrosine kinase activator activity IDA
IDA: 通过直接分析推断
30061385 GOA
enables transmembrane receptor protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
30061385 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
10445845 GOA
is active in plasma membrane IDA
IDA: 通过直接分析推断
34646012 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

LTK 蛋白结构

Gly_rich

Gly_rich: Glycine rich protein (116 - 358)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (511 - 777)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 864 a.a.
蛋白主名 其他名称

leukocyte tyrosine kinase receptor

protein tyrosine kinase 1

LTK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LTK P29376 ALKAL1 Homo sapiens Q6UXT8 26418745
种属内
LTK P29376 ALKAL1 Homo sapiens Q6UXT8 26418745
种属内
LTK P29376 EPHA2 Homo sapiens P29317 35384245
种属内
LTK P29376 EPHA2 Homo sapiens P29317 35384245
种属内
LTK P29376 EPHA2 Homo sapiens P29317 35384245
种属内
LTK P29376 PIK3R1 Homo sapiens P27986 35384245
种属内
LTK P29376 PIK3R1 Homo sapiens P27986 35384245
种属间: 跨种属相互作用 种属内: 同种属相互作用

LTK 抗体

目录号 产品名 应用 反应物种
HY-P83302 LTK Antibody (YA3047) WB, IHC-P Human, Rat

关联疾病

疾病名称 别名
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]

Her2-Receptor Positive Breast Cancer
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Inflammatory Myofibroblastic Tumor

Inflammatory Fibrosarcoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta LTK VGNC VGNC:84372
Mus musculus LTK MGD MGI:96840
Rattus norvegicus LTK RGD RGD:1309323
Others LTK NCBI