2. Gene
  3. LUM - lumican Gene

LUM - lumican Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：荧光素

种属: Homo sapiens

同用名: LDC; SLRR2D

基因 ID: 4060 | 基因类型: protein coding

关于 LUM

Cytogenetic location: 12q21.33 Genomic coordinates (GRCh38): 12:91,102,629-91,111,494 (from NCBI)

This gene has 3 transcripts (splice variants), 199 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 981.2), urinary bladder (RPKM 643.2) and 14 other tissues.

功能概要

该基因编码富含亮氨酸的小蛋白聚糖 (SLRP) 家族的一个成员，该家族包括核心蛋白聚糖、双糖链蛋白聚糖、纤维调节蛋白、角质形成蛋白聚糖、epiphycan 和骨甘氨酸。在这些双功能分子中，蛋白质部分结合胶原纤维，高度带电的亲水性糖胺聚糖调节纤维间的间距。 Lumican 是角膜的主要硫酸角质素蛋白聚糖，但也分布于全身的间质胶原基质中。 Lumican 可调节胶原纤维组织和环状生长、角膜透明度以及上皮细胞迁移和组织修复。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

LUM 基因产物(1)

mRNA Protein Name
NM_002345.4 NP_002336.1 lumican precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables collagen binding IDA
IDA: 通过直接分析推断
10892350 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25304424 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of fibrillar collagen trimer IDA
IDA: 通过直接分析推断
10734230 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LUM 蛋白结构

LRRNT

LRRNT: Leucine rich repeat N-terminal domain (37 - 65)

LRR_8

LRR_8: Leucine rich repeat (66 - 128)

LRR_8

LRR_8: Leucine rich repeat (138 - 196)

LRR_8

LRR_8: Leucine rich repeat (207 - 266)

  • 0
  • 100
  • 200
  • 300
  • 338 a.a.
蛋白主名 其他名称

lumican

KSPG lumican

LUM 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LUM P51884 PRKCA Homo sapiens P17252
Validated Y2H
32814053
种属内
LUM P51884 PRKCA Homo sapiens P17252
Y2H Pooling
32814053
种属内
LUM P51884 PRKCA Homo sapiens P17252
Y2H Array
32814053
种属内
LUM P51884 YWHAG Homo sapiens P61981
Y2H Pooling
32814053
种属内
LUM P51884 YWHAG Homo sapiens P61981
Validated Y2H
32814053
种属内
LUM P51884 YWHAG Homo sapiens P61981
Y2H Array
32814053
种属内
LUM P51884 KAT5 Homo sapiens Q92993
Validated Y2H
32814053
种属内
LUM P51884 KAT5 Homo sapiens Q92993
Y2H Pooling
32814053
种属内
LUM P51884 KAT5 Homo sapiens Q92993
Y2H Array
32814053
种属内
LUM P51884 SETDB1 Homo sapiens Q15047-2
Validated Y2H
32814053
种属内
LUM P51884 SETDB1 Homo sapiens Q15047-2
Y2H Array
32814053
种属内
LUM P51884 SETDB1 Homo sapiens Q15047-2
Y2H Pooling
32814053
种属内
LUM P51884 MMP14 Homo sapiens P50281
Enzymatic Study
25304424
种属内
LUM P51884 MMP14 Homo sapiens P50281
SPR
25304424
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LUM 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70369 Lumican/LUM Protein, Human (HEK293, His) P51884 (Q19-N338) ≥95%

关联疾病

疾病名称 别名
Cornea Plana

Flat Cornea
Macular Dystrophy, Corneal

Macular Corneal Dystrophy

MCD

Corneal Dystrophy, Macular Type

Groenouw Type Ii Corneal Dystrophy

Fehr Corneal Dystrophy

Macular Dystrophy, Corneal Type 1

Mcdc1

Macular Corneal Dystrophy Type Ii

Macular Corneal Dystrophy, Type Ii

Macular Corneal Dystrophy, Type I

Mcdc1, Formerly

Macular Dystrophy, Corneal, 1

Macular Corneal Dystrophy Type 1

Corneal Dystrophy Groenouw Type Ii

Corneal Dystrophy Macular Type

Macular Corneal Dystrophy Type I

Dystrophy, Macular, Corneal
Corneal Dystrophy, Posterior Amorphous

Posterior Amorphous Corneal Dystrophy

PACD

Chromosome 12q21.33 Deletion Syndrome

Posterior Amorphous Stromal Dystrophy
Degenerative Myopia

Pathological Myopia

Myopia, Degenerative

Degenerative Progressive High Myopia

Progressive High Myopia

Progressive High Myopia
Stromal Dystrophy
Myopia

Near-Sightedness

Short-Sightedness

Nearsightedness

Nearsighted

Near Vision

Close Sighted

Myopic

Short-Sighted

Near Sighted
Corneal Ectasia
Corneal Dystrophy, Congenital Stromal

Congenital Stromal Corneal Dystrophy

CSCD

Congenital Hereditary Stromal Dystrophy

Congenital Hereditary Stromal Dystrophy Of The Cornea

Congenital Stromal Dystrophy Of The Cornea

Dacs

Decorin-Associated Congenital Stromal Corneal Dystrophy

Dystrophia Corneae Parenchymatosa Congenita

Witschel Dystrophy

Dystrophy, Corneal, Stromal, Congenital
Refractive Error

Refractive Errors
Corneal Disease

Corneal Diseases

Corneal Disorders
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16747 Maralixibat chloride Inhibitor 99.08% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-101190 Volixibat / Phase 2
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-112023 Lumisterol 3 (>90%) 97.77% 否
HY-N0181A Lumisterol 99.41% 否
HY-RS07891 LUM Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus LUM VGNC VGNC:31081
Rattus norvegicus LUM RGD RGD:620984
Felis catus LUM VGNC VGNC:68109
Mus musculus LUM MGD MGI:109347
Canis familiaris LUM VGNC VGNC:42865
Macaca mulatta LUM VGNC VGNC:100076
Susscrofa domestica LUM NCBI
Others LUM NCBI
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