1. Gene
  2. TAFA1 - TAFA chemokine like family member 1 Gene

TAFA1 - TAFA chemokine like family member 1 Gene

中文名称:TAFA 趋化因子样家族成员 1

种属: Homo sapiens

同用名: TAFA-1; FAM19A1

基因 ID: 407738 | 基因类型: protein coding

关于 TAFA1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:67,991,544-68,545,621 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 3 paralogues. Biased expression in brain (RPKM 6.6) and prostate (RPKM 0.3).

功能概要

该基因是 TAFA 家族的成员,该家族由五个高度同源的基因组成,编码小的分泌蛋白。这些蛋白质在固定位置包含保守的半胱氨酸残基,并且与 CC 趋化因子家族的成员 MIP-1alpha 有远缘关系。 TAFA 蛋白主要在大脑的特定区域表达,并被假定作为大脑特异性趋化因子或神经因子发挥作用,充当免疫和神经细胞的调节剂。[RefSeq 提供,2008 年 7 月]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Jul 2008]

TAFA1 基因产物(2)

mRNA Protein Name
NM_001252216.2 NP_001239145.1 chemokine-like protein TAFA-1 precursor
NM_213609.4 NP_998774.2 chemokine-like protein TAFA-1 precursor
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
29453251 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TAFA1 蛋白结构

TAFA

TAFA: TAFA family (41 - 129)

  • 0
  • 100
  • 133 a.a.
蛋白主名 其他名称

chemokine-like protein TAFA-1

family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

TAFA1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TAFA1 Q7Z5A9 RABGGTB Homo sapiens P53611
Y2H Array
25416956
种属内
TAFA1 Q7Z5A9 RABGGTB Homo sapiens P53611
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TAFA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79169 TAFA1/FAM19A1 Protein, Human Q7Z5A9/NP_998774 (S26-T133) ≥95%

关联疾病

疾病名称 别名
Lissencephaly 9 With Complex Brainstem Malformation

LIS9

Posterior-Predominant Lissencephaly-Broad Flat Pons And Medulla-Midline Crossing Defects Syndrome

Williams-Beuren Syndrome

Williams Syndrome

WBS

Wms

Deletion 7q11.23

Monosomy 7q11.23

Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

Fanconi Schlesinger Syndrome

Beuren Syndrome

Elfin Facies Syndrome

Elfin Facies With Hypercalcemia

Hypercalcemia-Supravalvar Aortic Stenosis

Ws

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TAFA1 VGNC VGNC:78188
Rattus norvegicus TAFA1 RGD RGD:1563030
Bos taurus TAFA1 VGNC VGNC:28777
Mus musculus TAFA1 MGD MGI:2443695
Canis familiaris TAFA1 VGNC VGNC:82300
Felis catus TAFA1 VGNC VGNC:102710
Others TAFA1 NCBI