2. Gene
  3. NOMO3 - NODAL modulator 3 Gene

NOMO3 - NODAL modulator 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：节点调制器 3

种属: Homo sapiens

同用名: Nomo

基因 ID: 408050 | 基因类型: protein coding

关于 NOMO3

Cytogenetic location: 16p13.11 Genomic coordinates (GRCh38): 16:16,232,528-16,294,811 (from NCBI)

This gene has 30 transcripts (splice variants), 1 gene allele, 201 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 58.4), heart (RPKM 50.4) and 25 other tissues.

功能概要

该基因编码一种最初被认为与胶原酶基因家族有关的蛋白质。该基因是 16 号染色体短臂重复区域中三个高度相似的基因之一。这三个基因编码的蛋白质密切相关，可能具有相同的功能。由其中一个基因编码的蛋白质已被鉴定为参与脊椎动物发育过程中 Nodal 信号通路的蛋白质复合物的一部分。位于附近的 ABCC6 中的突变，而不是该基因中的突变与弹性假黄瘤有关。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein originally thought to be related to the collagenase gene family. This gene is one of three highly similar genes in a duplicated region on the short arm of chromosome 16. These three genes encode closely related proteins that may have the same function. The protein encoded by one of these genes has been identified as part of a protein complex that participates in the Nodal signaling pathway during vertebrate development. Mutations in ABCC6, which is located nearby, rather than mutations in this gene are associated with pseudoxanthoma elasticum. [provided by RefSeq, Jul 2008]

NOMO3 基因产物(1)

mRNA Protein Name
NM_001004067.4 NP_001004067.1 nodal modulator 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22046132 GOA
enables ribosome binding IDA
IDA: 通过直接分析推断
32820719 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in multi-pass transmembrane protein insertion into ER membrane IDA
IDA: 通过直接分析推断
36261522 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of multi-pass translocon complex IDA
IDA: 通过直接分析推断
36261522 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NOMO3 蛋白结构

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (130 - 203)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (330 - 403)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1222 a.a.
蛋白主名 其他名称

nodal modulator 3

pM5 protein 3

NOMO3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
NOMO3 P69849 P0C6X7-PRO_0000037315 Human SARS coronavirus P0C6X7-PRO_0000037315
Lumier
22046132
种属间
NOMO3 P69849 P0C6X7-PRO_0000037315 Human SARS coronavirus P0C6X7-PRO_0000037315
Y2H Pooling
22046132
种属内
NOMO3 P69849 GET4 Homo sapiens Q7L5D6
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Pseudoxanthoma Elasticum

PXE

Gronblad-Strandberg Syndrome

Pseudoxanthoma Elasticum, Modifier Of Severity Of

Gronblad-Strandberg-Touraine Syndrome

Gronblad Strandberg Syndrome

Groenblad-Strandberg Syndrome

Nevus Elasticus

Pxe - [Pseudoxanthoma Elasticum]
Superficial Urinary Bladder Cancer

Superficial Urinary Bladder Carcinoma

Carcinoma Of Urinary Bladder, Superficial
Supraglottis Cancer

Malignant Tumor Of Supraglottis

Supraglottis

Ca Larynx - Supraglottis

Malignant Neoplasm Of Extrinsic Larynx

Malignant Neoplasm Of Supraglottis

Malignant Supraglottic Tumor

Neoplasm Of Supraglottis
Microphthalmia, Isolated 4

Isolated Microphthalmia 4

MCOP4

Microphthalmia, Isolated, 4

Isolated Clinical Anophthalmia

Microphthalmia, Isolated, Type 4
Ulcerative Stomatitis

Stomatitis Ulcerative

Aphthous Stomatitis

Minor Oral Aphthous Ulceration
Leber Congenital Amaurosis 17

LCA17

Leber Congenital Amaurosis, Type 17
Noma

Cancrum Oris

Gangrenous Stomatitis

Oro-Facial Gangrene

Noma Neonatorum

Oral Gangrene

Oro-Facial Noma

Stomatitis Gangrenosa

Stomatonecrosis

Gangrene Stomatitis
Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder

Epidermoid Carcinoma Of The Urinary Bladder

Carcinoma Squamous Cell Bladder
Afferent Loop Syndrome

Afferent Limb Syndrome
Multiple Synostoses Syndrome

Symphalangism-Brachydactyly Syndrome

Deafness-Hermann Type Symphalangism Syndrome

Facio-Audio-Symphalangism

Hearing Loss-Hermann Type Symphalangism Syndrome

Wl Syndrome

Multiple Synostosis Syndrome
Shipyard Eye

Epidemic Keratoconjunctivitis

Ekc
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09424 NOMO3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NOMO3 MGD MGI:2385850
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