MEP1B - meprin A subunit beta Gene

中文名称：安眠蛋白 A 亚基β

种属: Homo sapiens

关于 MEP1B

功能概要

安眠蛋白是多域锌金属蛋白酶，在哺乳动物肾脏和肠道刷状缘膜以及白细胞和某些癌细胞中高度表达。它们参与多种肽和蛋白质底物的水解，并与癌症和肠道炎症有关。成熟的安眠药是进化相关但单独编码的 alpha 和/或 beta 亚基的寡聚体。 α 亚基的同源寡聚体被分泌，而含有 β 亚基的寡聚体被质膜结合。该基因编码β亚基。在小鼠中靶向破坏该基因会影响胚胎活力、肾脏基因表达谱以及肾脏和肠道中膜相关 α 亚基的分布。[RefSeq 提供，2011 年 10 月]

Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain Cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in Cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]