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  2. CD99 - CD99 molecule (Xg blood group) Gene

CD99 - CD99 molecule (Xg blood group) Gene

中文名称:CD99 分子 (Xg 血型)

种属: Homo sapiens

同用名: MIC2; HBA71; MIC2X; MIC2Y; MSK5X

基因 ID: 4267 | 基因类型: protein coding

关于 CD99

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:2,691,295-2,741,309 (from NCBI)

This gene has 15 transcripts (splice variants), 154 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 38.2), gall bladder (RPKM 35.8) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种细胞表面糖蛋白,参与白细胞迁移、T 细胞粘附、神经节苷脂 GM1 和跨膜蛋白转运,以及通过半胱天冬酶非依赖性途径导致的 T 细胞死亡。此外,编码的蛋白质可能具有重排肌动蛋白细胞骨架的能力,也可能在骨肉瘤中充当肿瘤抑制因子。该基因存在于 X 和 Y 染色体的假常染色体区域,并避免 X 染色体失活。有一个相关的假基因紧邻该基因座。[RefSeq 提供,2016 年 3 月]

The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin Cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus. [provided by RefSeq, Mar 2016]

CD99 基因产物(6)

mRNA Protein Name
NM_001122898.3 NP_001116370.1 CD99 antigen isoform b precursor
NM_001321367.2 NP_001308296.1 CD99 antigen isoform c precursor
NM_001321368.2 NP_001308297.1 CD99 antigen isoform d precursor
NM_001321369.2 NP_001308298.1 CD99 antigen isoform e precursor
NM_001321370.2 NP_001308299.1 CD99 antigen isoform f precursor
NM_002414.5 NP_002405.1 CD99 antigen isoform a precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
20374249 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CD99 蛋白结构

CD99L2

CD99L2: CD99 antigen like protein 2 (26 - 176)

  • 0
  • 100
  • 185 a.a.
蛋白主名 其他名称

CD99 antigen

E2 antigen

重组 CD99 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70752 CD99 Protein, Human (HEK293, Fc) P14209-1 (D23-D122) ≥95%
HY-P77623 CD99 Protein, Human (HEK293, His) P14209-1 (D23-D122) ≥95%

关联疾病

疾病名称 别名
Extraosseous Ewing Sarcoma

Extraosseous Ewing'S Sarcoma

Extraosseous Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Extraskeletal Ewing Sarcom

Sarcoma Extraosseous Ewings

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Lymphoblastic Lymphoma

Lymphoma, Lymphoblastic

Lymphoma Lymphoblastic

Precursor Cell Lymphoblastic Lymphoma

Precursor Cell Lymphoblastic Leukemia Lymphoma

Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral

Olfactory Neuroblastoma

Esthesioneuroblastoma

Asthesioneuroblastoma

Esthesioneuroepithelioma

Olfactory Esthesioneuroblastoma

Paranasal Sinus Olfactory Neuroblastoma

Esthesioneuroblastoma, Olfactory

Esthesioneuroblastoma Of Nasal Cavity

Intracranial Primitive Neuroectodermal Tumor

Intracranial Pnet

Intracranial Primitive Neuroectodermal Neoplasm

Testicular Fibroma
Mixed Endometrial Stromal And Smooth Muscle Tumor

Stromomyoma

Mixed Endometrial Stromal And Smooth Muscle Neoplasm

Askin'S Tumor

Askin Tumor

Askin Tumour

Askin'S Tumour

Epidural Spinal Canal Neoplasm

Extradural Tumor

Epidural Neoplasms

Epidural Neoplasm

Myocardium Cancer

Malignant Myocardial Tumor

Malignant Neoplasm Of Myocardium

Tumor Of Myocardium

Malignant Tumor Of Myocardium

Cerebellopontine Angle Primitive Neuroectodermal Tumor

Cerebellopontine Angle Pnet

Colon Carcinoma In Situ

Carcinoma In Situ Of Colon

Stage 0 Colonic Carcinoma

Stage 0 Carcinoma Of Colon

Intraepithelial Neoplasia Of Colon, High Grade

Carcinoma In Situ Of Cecum

Carcinoma In Situ Of Hepatic Flexure

Carcinoma In Situ Of Ileocecal Valve

Carcinoma In Situ Of Hepatic Flexure Of Colon

Intestine Carcinoma In Situ
Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Extraosseous Ewing'S Tumor

Extraosseous Ewing'S Tumour

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumour

Ectomesenchymoma

Rhabdomyosarcoma With Ganglionic Differentiation

Malignant Ectomesenchymoma

Central Nervous System Mesenchymal Non-Meningothelial Tumor

Central Nervous System Mesenchymal Non-Meningothelial Tumour

Non-Meningothelial Mesenchymal Tumor

Non-Meningothelial Mesenchymal Tumour

Small Cell Osteogenic Sarcoma

Small Cell Osteosarcoma

Round Cell Osteosarcoma

Osteosarcoma Small Cell

Teratoma

Teratomas

Desmoplastic Small Round Cell Tumor

Dsrct

Desmoplastic Small Round-Cell Tumor

Desmoplastic Small Round-Cell Neoplasm

Pulmonary Vein Leiomyosarcoma

Leiomyosarcoma Of The Pulmonary Vein

Retroperitoneal Neuroblastoma
Malignant Olfactory Nerve Neoplasm

Malignant Olfactory Nerve Tumor

Malignant Tumor Of Olfactory Nerve

Primary Malignant Neoplasm Of Olfactory Nerve

Ewing Sarcoma Of Bone

Ewing'S Sarcoma Of Bone

Bone Ewing Sarcoma

Bone Ewing'S Sarcoma

Bone Localized Ewing Sarcoma

Bone Localized Ewing'S Sarcoma

Ewing'S Sarcoma/Bone Peripheral Primitive Neuroectodermal Tumor

Localized Skeletal Ewing'S Sarcoma

Localized Bone Ewing Sarcoma

Conventional Osteosarcoma

Intracortical Osteosarcoma

Conventional Central Osteosarcoma

Intracortical Osteogenic Sarcoma

Medullary Osteosarcoma

Ganglioneuroma
Cranial Nerve Malignant Neoplasm

Cranial Nerve Neoplasms

Malignant Neoplasm Of Cranial Nerve

Malignant Tumor Of Cranial Nerve

Malignant Tumor Of The Cranial Nerve

Fibroma
Supratentorial Primitive Neuroectodermal Tumor

Supratentorial Pnet

Supratentorial Embryonal Tumor, Not Otherwise Specified

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Central Nervous System Primitive Neuroectodermal Neoplasm

Cpnet

Monophasic Synovial Sarcoma

Monophasic Sarcoma Of Synovium

Meninges Hemangiopericytoma

Hemangiopericytoma Of Meninges

Meningeal Hemangiopericytoma

Testicular Granulosa Cell Tumor

Granulosa Cell Tumor Of Testis

Granulosa Cell Tumour Of Testis

Testicular Granulosa Cell Tumour

Extraskeletal Mesenchymal Chondrosarcoma

Mesenchymal Extraosseous Chondrosarcoma

Epithelioid Cell Synovial Sarcoma

Synovial Sarcoma, Epithelioid Cell

Epithelioid Synovial Sarcoma

Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm

Bone Osteosarcoma

Osteosarcoma Of Bone

Primary Osteosarcoma Of Bone

Congenital Toxoplasmosis

Toxoplasmosis, Congenital

Mother-To-Child Transmission Of Toxoplasmosis

Toxoplasma Embryofetopathy

Toxoplasma Embryopathy

Toxoplasmosis - Congen.

Toxoplasmosis Congenital

Mesenchymal Chondrosarcoma

Chondrosarcoma, Mesenchymal

Chondrosarcoma Mesenchymal

Juvenile Type Testicular Granulosa Cell Tumor

Juvenile Granulosa Cell Tumor

Juvenile Granulosa Cell Tumour

Juvenile Type Granulosa Cell Neoplasm

Juvenile Type Granulosa Cell Tumor

Juvenile Type Granulosa Cell Tumour

Juvenile Type Testicular Granulosa Cell Tumour

Skeletal Muscle Cancer

Malignant Tumor Of Skeletal Muscle

Skeletal Muscle Neoplasm

Biphasic Synovial Sarcoma

Synovial Sarcoma, Biphasic

Biphasic Sarcoma Of Synovium

Coccidiosis

Intestinal Coccidiosis

Enteric Coccidiosis

Castleman Disease

Angiofollicular Ganglionic Hyperplasia

Angiofollicular Lymph Hyperplasia

Giant Lymph Node Hyperplasia

Castleman'S Disease

Angiofollicular Lymph Node Hyperplasia

Lymphoid Hamartoma

Benign Giant Lymphoma

Angiolymphoid Hyperplasia

Malignant Teratoma

Immature Teratoma

Malignant Extragonadal Teratoma

Primary Malignant Extragonadal Teratoma

Teratoma, Malignant, Nos

Teratoma, Malignant

Immature Extragonadal Teratoma

Muscle Cancer

Myosarcoma

Malignant Neoplasm Of Muscle

Malignant Tumor Of Muscle

Malignant Tumor Of The Muscle

Muscle Neoplasms

Myomatous Neoplasm

Medulloepithelioma

Diktyoma, Malignant

Medulloepithelioma, Central Nervous System

Medulloepithelioma Of The Central Nervous System

Rhabdomyosarcoma
Kidney Fibrosarcoma

Fibrosarcoma Of The Kidney

Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Sarcoma, Synovial

Synovial Sarcoma

Synovialosarcoma

Synovial Cell Sarcoma

Sarcoma Synovial

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma

Emc

Myxoid Extraosseous Chondrosarcoma

Embryonal Rhabdomyosarcoma

Rhabdomyosarcoma, Embryonal

Rhabdomyosarcoma Embryonal

Botryoid Rhabdomyosarcoma

Erms

Spindle Cell Rhabdomyosarcomas

Kidney Clear Cell Sarcoma

Clear Cell Sarcoma Of Kidney

Childhood Kidney Clear Cell Sarcoma

Renal Clear Cell Sarcoma

Ccsk

Clear Cell Sarcoma Of The Kidney

Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2

Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus CD99 MGD MGI:1913728
Rattus norvegicus CD99 RGD RGD:1594332
Bos taurus CD99 VGNC VGNC:50554
Canis familiaris CD99 VGNC VGNC:54127