2. Gene
  3. MLF1 - myeloid leukemia factor 1 Gene

MLF1 - myeloid leukemia factor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：骨髓性白血病因子 1

种属: Homo sapiens

基因 ID: 4291 | 基因类型: protein coding

关于 MLF1

Cytogenetic location: 3q25.32 Genomic coordinates (GRCh38): 3:158,571,194-158,606,456 (from NCBI)

This gene has 21 transcripts (splice variants), 192 orthologues, 1 paralogue and is associated with 55 phenotypes. Biased expression in testis (RPKM 97.9), heart (RPKM 24.2) and 4 other tissues.

功能概要

该基因编码的癌蛋白被认为在造血细胞的表型决定中发挥作用。该基因和核磷蛋白之间的易位与骨髓增生异常综合征和急性髓性白血病有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 9 月]

This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]

MLF1 基因产物(20)

mRNA Protein Name
NM_001130156.3 NP_001123628.1 myeloid leukemia factor 1 isoform 2
NM_001130157.3 NP_001123629.1 myeloid leukemia factor 1 isoform 2
NM_001195432.4 NP_001182361.2 myeloid leukemia factor 1 isoform 5
NM_001195433.2 NP_001182362.1 myeloid leukemia factor 1 isoform 4
NM_001195434.2 NP_001182363.1 myeloid leukemia factor 1 isoform 5
NM_001369781.1 NP_001356710.1 myeloid leukemia factor 1 isoform 7
NM_001369782.1 NP_001356711.1 myeloid leukemia factor 1 isoform 8
NM_001369783.1 NP_001356712.1 myeloid leukemia factor 1 isoform 6
NM_001369784.1 NP_001356713.1 myeloid leukemia factor 1 isoform 2
NM_001369785.1 NP_001356714.1 myeloid leukemia factor 1 isoform 5
NM_001378845.1 NP_001365774.1 myeloid leukemia factor 1 isoform 9
NM_001378846.1 NP_001365775.1 myeloid leukemia factor 1 isoform 5
NM_001378847.1 NP_001365776.1 myeloid leukemia factor 1 isoform 2
NM_001378848.1 NP_001365777.1 myeloid leukemia factor 1 isoform 2
NM_001378850.1 NP_001365779.1 myeloid leukemia factor 1 isoform 10
NM_001378851.1 NP_001365780.1 myeloid leukemia factor 1 isoform 11
NM_001378852.1 NP_001365781.1 myeloid leukemia factor 1 isoform 12
NM_001378853.1 NP_001365782.1 myeloid leukemia factor 1 isoform 13
NM_001378855.1 NP_001365784.1 myeloid leukemia factor 1 isoform 14
NM_022443.5 NP_071888.1 myeloid leukemia factor 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12176995 GOA
enables protein domain specific binding IDA
IDA: 通过直接分析推断
12176995 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of negative effect regulation of cell cycle G1/S phase transition IPI
IPI: 通过物理相互作用推断
15861129 GOA
acts upstream of positive effect regulation of signal transduction by p53 class mediator IPI
IPI: 通过物理相互作用推断
15861129 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
15861129 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MLF1 蛋白结构

Mlf1IP

Mlf1IP: Myelodysplasia-myeloid leukemia factor 1-interacting protein (26 - 203)

  • 0
  • 100
  • 200
  • 268 a.a.
蛋白主名 其他名称

myeloid leukemia factor 1

myelodysplasia-myeloid leukemia factor 1

MLF1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MLF1 P58340 MLF2 Homo sapiens Q15773
Lumier
25036637
种属内
MLF1 P58340 DNAJB6 Homo sapiens O75190
Anti Tag CoIP
33961781
种属内
MLF1 P58340 BAG2 Homo sapiens O95816
Lumier
25036637
种属内
MLF1 P58340 BAG2 Homo sapiens O95816
Anti Tag CoIP
33961781
种属内
MLF1 P58340 YWHAE Homo sapiens P62258
ITC
22151054
种属内
MLF1 P58340 YWHAE Homo sapiens P62258
X-Ray Diffraction
22151054
种属内
MLF1 P58340 HAX1 Homo sapiens O00165
Lumier
25036637
种属内
MLF1 P58340 HAX1 Homo sapiens O00165
Anti Tag CoIP
33961781
种属内
MLF1 P58340 PSMD2 Homo sapiens Q13200
Lumier
25036637
种属内
MLF1 P58340 DNAJB2 Homo sapiens P25686
Anti Tag CoIP
33961781
种属内
MLF1 P58340 DNAJB2 Homo sapiens P25686
Lumier
25036637
种属内
MLF1 P58340 MAGEA11 Homo sapiens P43364
Validated Y2H
26871637
种属内
MLF1 P58340 MAGEA11 Homo sapiens P43364
Y2H Array
26871637
种属内
MLF1 P58340 MAGEA11 Homo sapiens P43364
Y2H Prey Pooling
26871637
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Thyroid Carcinoma

Thyroid Cancer

Malignant Neoplasm Of Thyroid

Thyroid Neoplasm
Myeloid Leukemia

Myeloid Leukaemia

Leukaemia Myelogenous

Leukemia Myelogenous

Myeloid Granulocytic Leukaemia

Myeloid Granulocytic Leukemia

Non-Lymphocytic Leukemia

Leukemia, Myeloid

Granulocytic Leukaemia

Myelogenous Leukaemia

Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Myelodysplastic Syndrome

Myelodysplastic Syndromes

Myelodysplasia

MDS

Myelodysplastic Syndrome Included

Myelodysplastic Syndrome, Susceptibility To, Included

Myelodysplastic Syndrome, Somatic

Myelodysplastic Syndrome, Susceptibility To
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor

Neuroendocrine Tumor Of The Small Intestine

Net Of The Small Intestine

Neuroendocrine Neoplasm Of The Small Intestine

Neuroendocrine Tumor Of Small Bowel

Small Intestinal Neuroendocrine Neoplasm
Unilateral Focal Polymicrogyria
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 1

Muscular Dystrophy, Limb-Girdle, Type 1e

Lgmd1d

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1d

LGMDD1

Lgmd1e

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1

Limb-Girdle Muscular Dystrophy Type 1d

Muscular Dystrophy, Limb-Girdle, Type 1d

Muscular Dystrophy, Limb-Girdle, Type 1d, Formerly

Lgmd1d, Formerly

Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1e

Muscular Dystrophy Limb-Girdle Type 1d

Muscular Dystrophy Limb-Girdle Type 1e

Dnajb6-Related Limb-Girdle Muscular Dystrophy D1

Dnajb6-Related Lgmd D1

Lgmd Type 1d

Limb-Girdle Muscular Dystrophy 1e

Limb-Girdle Muscular Dystrophy-1d, Autosomal Dominant

Dystrophy, Muscular, Limb-Girdle, Autosomal Dominant, Type 1

Dystrophy, Muscular, Limb-Girdle, Type 1e
Small Intestine Benign Neoplasm

Neoplasm Of Small Intestine

Small Intestinal Neoplasm

Neoplasm Of The Small Intestine

Small Bowel Cancer

Small Intestine Cancer

Malignant Neoplasm Of Small Intestine, Unspecified

Malignant Tumour Of Small Bowel

Malignant Tumour Of Small Intestine

Primary Malignant Neoplasm Of Meckel Diverticulum
Leukemia, Acute Myeloid

Acute Myeloid Leukemia

Leukemia, Acute Myelogenous

Acute Myelogenous Leukemia

AML

Leukemia, Acute Myeloid, Susceptibility To

Acute Myeloblastic Leukemia

Leukemia, Acute Myeloid, Reduced Survival In, Somatic

Acute Myeloid Leukaemia

Leukemia, Myelocytic, Acute

Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome

Secondary Aml

Acute Myelocytic Leukemia

Acute Myeloid Leukemia, Somatic

Leukemia, Acute Myeloid, Somatic

Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic

Acute Myeloblastic Leukaemia

Acute Myelogenous Leukaemia

Aml - Acute Myeloid Leukemia

Acute Myeloid Leukemia With Cebpa Somatic Mutations

Aml With Cebpa Somatic Mutations

Inherited Acute Myeloid Leukemia

Familial Aml

Inherited Aml

Pure Familial Aml

Pure Familial Acute Myeloid Leukemia

Secondary Acute Myeloid Leukemia

Therapy-Related Aml And Myelodysplastic Syndrome

Acute Myeloid Leukemia, Secondary

Acute Non-Lymphoblastic Leukemia

Acute Non-Lymphocytic Leukemia

Acute Biphenotypic Leukemia

Acute Undifferentiated Leukemia

Acute Myeloblastic Leukaemia With Multilineage Dysplasia

Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission

Acute Myeloid Leukaemia With Myelodysplasia-Related Features
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08487 MLF1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MLF1 RGD RGD:1306854
Mus musculus MLF1 MGD MGI:1341819
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