2. Gene
  3. FOXO4 - forkhead box O4 Gene

FOXO4 - forkhead box O4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：叉头盒 O4

种属: Homo sapiens

同用名: AFX; AFX1; MLLT7

基因 ID: 4303 | 基因类型: protein coding

关于 FOXO4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,095,851-71,103,532 (from NCBI)

This gene has 4 transcripts (splice variants), 202 orthologues, 42 paralogues and is associated with 52 phenotypes. Broad expression in placenta (RPKM 74.9), testis (RPKM 15.0) and 21 other tissues.

功能概要

该基因编码 O 类有翼螺旋/叉头转录因子家族的成员。此类编码的蛋白质受生长和分化相关因素的调节，表明它们在这些过程中发挥作用。涉及 X 染色体上的该基因和位于 11 号染色体上的编码 DNA 结合蛋白的果蝇三胸基因的同系物的易位与白血病有关。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2010 年 1 月]

This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]

FOXO4 基因产物(2)

mRNA Protein Name
NM_001170931.2 NP_001164402.1 forkhead box protein O4 isoform 2
NM_005938.4 NP_005929.2 forkhead box protein O4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
10783894 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
11689711 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
10783894 GOA
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
16054032 GOA
enables beta-catenin binding IDA
IDA: 通过直接分析推断
15905404 GOA
enables enzyme binding IPI
IPI: 通过物理相互作用推断
15126506 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25609649 GOA
enables nucleic acid binding EXP
EXP: 通过实验结果推断
11352721 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15084259 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
23332764 GOA
enables sequence-specific DNA binding IMP
IMP: 通过突变表型推断
22972301 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in insulin receptor signaling pathway IDA
IDA: 通过直接分析推断
10217147 GOA
involved in negative regulation of G0 to G1 transition IDA
IDA: 通过直接分析推断
10783894 GOA
involved in negative regulation of angiogenesis IDA
IDA: 通过直接分析推断
12761217 GOA
involved in negative regulation of cell population proliferation IDA
IDA: 通过直接分析推断
10783894 GOA
involved in negative regulation of smooth muscle cell differentiation IDA
IDA: 通过直接分析推断
16054032 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11689711 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15126506 GOA
involved in response to oxidative stress IDA
IDA: 通过直接分析推断
36075446 GOA
involved in stem cell differentiation IMP
IMP: 通过突变表型推断
22972301 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16964248 GOA
located in cytosol IDA
IDA: 通过直接分析推断
16272144 GOA
located in nucleus IDA
IDA: 通过直接分析推断
16272144 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FOXO4 蛋白结构

Forkhead

Forkhead: Forkhead domain (104 - 185)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 505 a.a.
蛋白主名 其他名称

forkhead box protein O4

fork head domain transcription factor AFX1

FOXO4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXO4 P98177 SIRT1 Homo sapiens Q96EB6
Anti Tag CoIP
15126506
种属内
FOXO4 P98177 REL Homo sapiens Q04864
Validated Y2H
25416956
种属内
FOXO4 P98177 REL Homo sapiens Q04864
Y2H Prey Pooling
25416956
种属内
FOXO4 P98177 SMAD4 Homo sapiens Q13485
Anti Tag CoIP
15084259
种属内
FOXO4 P98177 YWHAE Homo sapiens P62258
Crosslink
36931259
种属内
FOXO4 P98177 Foxg1 Mus musculus Q60987
Anti Tag CoIP
15084259
种属内
FOXO4 P98177 SMAD3 Homo sapiens P84022
Anti Tag CoIP
15084259
种属内
FOXO4 P98177 FOXO4 Homo sapiens P98177
TAP
25609649
种属内
FOXO4 P98177 H1-2 Homo sapiens P16403
Crosslink
30021884
种属内
FOXO4 P98177 SFN Homo sapiens P31947
Validated Y2H
25416956
种属内
FOXO4 P98177 Crebbp Mus musculus P45481
Anti Tag CoIP
15126506
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Rhabdomyosarcoma 2

Alveolar Rhabdomyosarcoma

Rhabdomyosarcoma, Alveolar

Rhabdomyosarcoma Alveolar

RMS2

Rmsa

Rhabdomyosarcoma 2, Alveolar

Alveolar Childhood Rhabdomyosarcoma

Arms

Rhabdomyosarcoma, Type 2
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153347 JY-2 99.75% 否
HY-P4157 FOXO4-DRI 99.93% 否
HY-P4157A FOXO4-DRI acetate / 否
HY-RS05071 FOXO4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris FOXO4 VGNC VGNC:40964
Macaca mulatta FOXO4 VGNC VGNC:72712
Rattus norvegicus FOXO4 RGD RGD:1561201
Bos taurus FOXO4 VGNC VGNC:29100
Mus musculus FOXO4 MGD MGI:1891915
Felis catus FOXO4 VGNC VGNC:68274
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