H1-2 - H1.2 linker histone, cluster member Gene

中文名称：H1.2 接头组蛋白，簇成员

种属: Homo sapiens

同用名: H1C; H1.2; H1F2; H1s-1; HIST1H1C

关于 H1-2

功能概要

组蛋白是负责真核生物染色体纤维核小体结构的基本核蛋白。四个核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一个的两个分子形成一个八聚体，大约 146 bp 的 DNA 被包裹在称为核小体的重复单元中。接头组蛋白 H1 与核小体之间的接头 DNA 相互作用，并在将染色质压缩成更高级结构中发挥作用。该基因是无内含子的，编码复制依赖组蛋白，该组蛋白是组蛋白 H1 家族的一员。该基因的转录本缺少 polyA 尾巴，而是包含一个回文终止元件。该基因存在于 6 号染色体上的大型组蛋白基因簇中。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]