2. Gene
  3. NAP1L1 - nucleosome assembly protein 1 like 1 Gene

NAP1L1 - nucleosome assembly protein 1 like 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核小体装配蛋白 1 like 1

种属: Homo sapiens

同用名: NRP; NAP1; NAP1L

基因 ID: 4673 | 基因类型: protein coding

关于 NAP1L1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,036,585-76,084,685 (from NCBI)

This gene has 26 transcripts (splice variants), 239 orthologues and 18 paralogues. Ubiquitous expression in ovary (RPKM 100.8), lymph node (RPKM 74.3) and 25 other tissues.

功能概要

该基因编码核小体组装蛋白 (NAP) 家族的成员。这种蛋白质参与 DNA 复制，并可能在调节染色质形成中发挥作用，并有助于调节细胞增殖。可变剪接导致编码不同异构体的多个转录变体；然而，并不是所有的都得到了充分的描述。[RefSeq 提供，2015 年 4 月]

This gene encodes a member of the nucleosome assembly protein (NAP) family. This protein participates in DNA replication and may play a role in modulating chromatin formation and contribute to the regulation of cell proliferation. Alternative splicing results in multiple transcript variants encoding different isoforms; however, not all have been fully described. [provided by RefSeq, Apr 2015]

NAP1L1 基因产物(5)

mRNA Protein Name
NM_001307924.3 NP_001294853.1 nucleosome assembly protein 1-like 1 isoform 2
NM_001330231.2 NP_001317160.1 nucleosome assembly protein 1-like 1 isoform 1
NM_001330232.2 NP_001317161.1 nucleosome assembly protein 1-like 1 isoform 3
NM_004537.7 NP_004528.1 nucleosome assembly protein 1-like 1 isoform 1
NM_139207.5 NP_631946.1 nucleosome assembly protein 1-like 1 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables histone chaperone activity IDA
IDA: 通过直接分析推断
21211722 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11940655 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NAP1L1 蛋白结构

NAP

NAP: Nucleosome assembly protein (NAP) (75 - 346)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
蛋白主名 其他名称

nucleosome assembly protein 1-like 1

HSP22-like protein interacting protein

NAP1L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NAP1L1 P55209 NAP1L4 Homo sapiens Q99733
Anti Tag CoIP
33961781
种属内
NAP1L1 P55209 NAP1L4 Homo sapiens Q99733
Anti Tag CoIP
28514442
种属内
NAP1L1 P55209 NR2F6 Homo sapiens P10588
TAP
20195357
种属内
NAP1L1 P55209 DLST Homo sapiens P36957
Y2H Pooling
16169070
种属内
NAP1L1 P55209 RPL23A Homo sapiens P62750
Anti Tag CoIP
33961781
种属内
NAP1L1 P55209 NAP1L2 Homo sapiens Q9ULW6
Y2H Prey Pooling
32296183
种属内
NAP1L1 P55209 NAP1L2 Homo sapiens Q9ULW6
Y2H Array
32296183
种属内
NAP1L1 P55209 NAP1L2 Homo sapiens Q9ULW6
Validated Y2H
32296183
种属内
NAP1L1 P55209 EP300 Homo sapiens Q09472
Pull Down
11940655
种属内
NAP1L1 P55209 EP300 Homo sapiens Q09472
Anti Bait CoIP
11940655
种属内
NAP1L1 P55209 TERF1 Homo sapiens P54274
Pull Down
21044950
种属内
NAP1L1 P55209 TTLL10 Homo sapiens Q6ZVT0
Anti Bait CoIP
18331838
种属内
NAP1L1 P55209 TTLL10 Homo sapiens Q6ZVT0
Enzymatic Study
18331838
种属内
NAP1L1 P55209 GAS2L2 Homo sapiens Q8NHY3
Validated Y2H
32296183
种属内
NAP1L1 P55209 CREBBP Homo sapiens Q92793
Pull Down
11940655
种属间
NAP1L1 P55209 tat Human immunodeficiency virus P04608
Pull Down
18226242
种属间: 跨种属相互作用 种属内: 同种属相互作用

NAP1L1 抗体

目录号 产品名 应用 反应物种
HY-P82747 NAP1L1 Antibody (YA2492) WB, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Human Herpesvirus 8

HHV8S

Human Herpesvirus 8, Susceptibility To

Hhv-8

Hhv-8, Susceptibility To

HHV8

Kaposi Sarcoma
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Polyhydramnios
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% 否
HY-RS09026 NAP1L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NAP1L1 VGNC VGNC:57999
Felis catus NAP1L1 VGNC VGNC:97521
Mus musculus NAP1L1 MGD MGI:1855693
Macaca mulatta NAP1L1 VGNC VGNC:100082
Rattus norvegicus NAP1L1 RGD RGD:71094
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