2. Gene
  3. NEU2 - neuraminidase 2 Gene

NEU2 - neuraminidase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经氨酸酶 2

种属: Homo sapiens

同用名: SIAL2

基因 ID: 4759 | 基因类型: protein coding

关于 NEU2

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:233,032,672-233,035,057 (from NCBI)

This gene has 1 transcript (splice variant), 115 orthologues and 3 paralogues. Low expression observed in reference dataset.

功能概要

该基因属于糖水解酶家族，可从糖蛋白和糖脂中去除唾液酸残基。 COS7 细胞中的表达研究证实该基因编码功能性唾液酸酶。细胞分级实验证明了其胞质定位。[RefSeq 提供，2008 年 7 月]

This gene belongs to a family of glycohydrolytic Enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments. [provided by RefSeq, Jul 2008]

NEU2 基因产物(1)

mRNA Protein Name
NM_005383.2 NP_005374.2 sialidase-2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables exo-alpha-sialidase activity IDA
IDA: 通过直接分析推断
14613940 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ganglioside catabolic process IDA
IDA: 通过直接分析推断
14613940 GOA
involved in glycoprotein catabolic process IDA
IDA: 通过直接分析推断
14613940 GOA
involved in oligosaccharide catabolic process IDA
IDA: 通过直接分析推断
14613940 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of catalytic complex IDA
IDA: 通过直接分析推断
26193330 GOA
located in cytosol IDA
IDA: 通过直接分析推断
10561456 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NEU2 蛋白结构

BNR_2

BNR_2: BNR repeat-like domain (33 - 342)

  • 0
  • 100
  • 200
  • 300
  • 380 a.a.
蛋白主名 其他名称

sialidase-2

N-acetyl-alpha-neuraminidase 2

NEU2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NEU2 Q9Y3R4 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
NEU2 Q9Y3R4 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
NEU2 Q9Y3R4 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25910212
种属内
NEU2 Q9Y3R4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25910212
种属内
NEU2 Q9Y3R4 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Bait-Prey Pool
25910212
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NEU2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74733 NEU2 Protein, Human (HEK293, His) Q9Y3R4 (M1-Q380) ≥95%

关联疾病

疾病名称 别名
Glycoproteinosis

Sialidosis

Mucolipidosis Type I

Mucolipidoses

Cherry Red Spot Myoclonus Syndrome

Mucolipidosis I

Myoclonus Cherry Red Spot Syndrome

Type I Mucolipidosis

Lipomucopolysaccharidosis

Disorders Of Glycoprotein Metabolism

Glycoprotein Storage Disorder
Galactosialidosis

Goldberg Syndrome

Neuraminidase Deficiency With Beta-Galactosidase Deficiency

Ppca Deficiency

GSL

Lysosomal Protective Protein Deficiency

Cathepsin A Deficiency

Neuraminidase/Beta-Galactosidase Expression

Protective Protein/Cathepsin A Deficiency

Ngbe

Cathepsin A Deficiency Of

Lysosomal Protective Protein Deficiency Of

Deficiency Of Cathepsin A

Neuraminidase Beta-Galactosidase Deficiency

Protective Protein Cathepsin A Deficiency
Breast Medullary Carcinoma

Medullary Breast Carcinoma

Medullary Breast Carcinoma With Lymphoid Stroma

Medullary Carcinoma Of Breast
Mucolipidosis
Breast Rhabdomyosarcoma

Rhabdomyosarcoma Of The Breast
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125798 2,3-Dehydro-2-deoxy-N-acetylneuraminic acid Inhibitor ≥99.0% 否
HY-P1855 HER2/neu (654-662) GP2 98.04% 否
HY-W087187 DOTAGA-anhydride / 否
HY-121605 RL71 97.44% 否
HY-P10569 Biotin HER-2 substrate peptide / 否
HY-P5745 TYVPANASL / 否
HY-RS09216 NEU2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NEU2 MGD MGI:1344417
Felis catus NEU2 VGNC VGNC:80291
Bos taurus NEU2 VGNC VGNC:50231
Canis familiaris NEU2 VGNC VGNC:54976
Macaca mulatta NEU2 VGNC VGNC:75317
Rattus norvegicus NEU2 RGD RGD:3164
Others NEU2 NCBI
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