2. Gene
  3. NFIB - nuclear factor I B Gene

NFIB - nuclear factor I B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核因子 IB

种属: Homo sapiens

同用名: CTF; MACID; NF1-B; NFI-B; NFIB2; NFIB3; NF-I/B; NFI-RED; HMGIC/NFIB

基因 ID: 4781 | 基因类型: protein coding

关于 NFIB

Cytogenetic location: 9p23-p22.3 Genomic coordinates (GRCh38): 9:14,081,843-14,532,077 (from NCBI)

This gene has 22 transcripts (splice variants), 213 orthologues, 3 paralogues and is associated with 78 phenotypes. Ubiquitous expression in fat (RPKM 8.5), brain (RPKM 6.3) and 24 other tissues.

功能概要

启用 DNA 结合转录激活剂活性，RNA 聚合酶 II 特异性； RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；和转录调节抑制剂活性。参与大脑发育； DNA 结合活性的负调节； RNA 聚合酶 II 对转录的调控。位于纤维中心和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription regulator inhibitor activity. Involved in brain development; negative regulation of DNA binding activity; and regulation of transcription by RNA polymerase II. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NFIB 基因产物(28)

mRNA Protein Name
NM_001190737.2 NP_001177666.1 nuclear factor 1 B-type isoform 1
NM_001190738.2 NP_001177667.1 nuclear factor 1 B-type isoform 2
NM_001282787.2 NP_001269716.1 nuclear factor 1 B-type isoform 4
NM_001369458.1 NP_001356387.1 nuclear factor 1 B-type isoform 5
NM_001369459.1 NP_001356388.1 nuclear factor 1 B-type isoform 6
NM_001369460.1 NP_001356389.1 nuclear factor 1 B-type isoform 7
NM_001369461.1 NP_001356390.1 nuclear factor 1 B-type isoform 8
NM_001369462.1 NP_001356391.1 nuclear factor 1 B-type isoform 9
NM_001369463.1 NP_001356392.1 nuclear factor 1 B-type isoform 10
NM_001369464.1 NP_001356393.1 nuclear factor 1 B-type isoform 11
NM_001369465.1 NP_001356394.1 nuclear factor 1 B-type isoform 12
NM_001369466.1 NP_001356395.1 nuclear factor 1 B-type isoform 13
NM_001369467.1 NP_001356396.1 nuclear factor 1 B-type isoform 14
NM_001369468.1 NP_001356397.1 nuclear factor 1 B-type isoform 15
NM_001369469.1 NP_001356398.1 nuclear factor 1 B-type isoform 16
NM_001369470.1 NP_001356399.1 nuclear factor 1 B-type isoform 17
NM_001369471.1 NP_001356400.1 nuclear factor 1 B-type isoform 18
NM_001369472.1 NP_001356401.1 nuclear factor 1 B-type isoform 19
NM_001369473.1 NP_001356402.1 nuclear factor 1 B-type isoform 20
NM_001369474.1 NP_001356403.1 nuclear factor 1 B-type isoform 21
NM_001369475.1 NP_001356404.1 nuclear factor 1 B-type isoform 22
NM_001369476.1 NP_001356405.1 nuclear factor 1 B-type isoform 23
NM_001369477.1 NP_001356406.1 nuclear factor 1 B-type isoform 24
NM_001369478.1 NP_001356407.1 nuclear factor 1 B-type isoform 25
NM_001369479.1 NP_001356408.1 nuclear factor 1 B-type isoform 26
NM_001369480.1 NP_001356409.1 nuclear factor 1 B-type isoform 27
NM_001369481.1 NP_001356410.1 nuclear factor 1 B-type isoform 28
NM_005596.3 NP_005587.2 nuclear factor 1 B-type isoform 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables DNA binding IDA
IDA: 通过直接分析推断
9099724 GOA
enables DNA binding IDA
IDA: 通过直接分析推断
9099724 GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
19540848 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
9099724 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
19540848 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25258084 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription regulator inhibitor activity IDA
IDA: 通过直接分析推断
9099724 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in brain development IMP
IMP: 通过突变表型推断
30388402 GOA
involved in negative regulation of DNA binding IDA
IDA: 通过直接分析推断
9099724 GOA
involved in negative regulation of miRNA transcription IMP
IMP: 通过突变表型推断
18384814 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9099724 GOA
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
30388402 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9099724 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
9099724 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NFIB 蛋白结构

NfI_DNAbd_pre-N

NfI_DNAbd_pre-N: Nuclear factor I protein pre-N-terminus (5 - 47)

MH1

MH1: MH1 domain (70 - 171)

CTF_NFI

CTF_NFI: CTF/NF-I family transcription modulation region (209 - 415)

  • 0
  • 100
  • 200
  • 300
  • 420 a.a.
蛋白主名 其他名称

nuclear factor 1 B-type

CCAAT-box-binding transcription factor

NFIB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NFIB O00712 NFIC Homo sapiens P08651
Anti Tag CoIP
33961781
种属内
NFIB O00712 NFIC Homo sapiens P08651
Affinity Chrom
35140242
种属内
NFIB O00712 NFIC Homo sapiens P08651
BioID
35140242
种属间: 跨种属相互作用 种属内: 同种属相互作用

NFIB 抗体

目录号 产品名 应用 反应物种
HY-P81647 NFIB Antibody (YA1392) WB, IP Human, Rat

关联疾病

疾病名称 别名
Macrocephaly, Acquired, With Impaired Intellectual Development

MACID

Macrocephaly, Acquired, With Mental Retardation
Adenoid Cystic Carcinoma

Adenocystic Carcinoma

Cribriform Carcinoma

Cylindroma

Carcinoma Adenoid Cystic

Carcinoma, Adenoid Cystic

Adenoid Cystic Carcinoma Of Salivary Gland

Eccrine Dermal Cylindroma

Carcinoma, Cribriform
Breast Adenoid Cystic Carcinoma

Adenoid Cystic Breast Carcinoma

Adenoid Cystic Carcinoma Of Breast

Mammary Adenocystic Carcinoma
Lung Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lung

Pulmonary Adenoid Cystic Carcinoma
Sublingual Gland Adenoid Cystic Carcinoma
Sublingual Gland Cancer

Malignant Tumor Of Sublingual Gland

Malignant Tumor Of The Sublingual Gland
Synchronous Bilateral Breast Carcinoma
Tonsil Cancer

Tonsillar Neoplasms

Malignant Neoplasm Of Faucial Tonsil

Malignant Neoplasm Of Palatine Tonsil

Malignant Neoplasm Of Tonsil, Faucial

Malignant Tonsillar Tumor

Malignant Tumor Of Tonsil

Tonsillar Carcinoma

Malignant Neoplasm Tonsil
Oropharynx Cancer

Oropharyngeal Cancer

Oropharyngeal Carcinoma

Malignant Neoplasm Of Oropharynx

Malignant Oropharyngeal Tumor

Malignant Tumor Of Oropharynx

Malignant Tumour Of Mesopharynx

Oropharyngeal Cancer, Adult

Cancer Of The Oropharynx
Salivary Gland Carcinoma

Salivary Gland Cancer

Malignant Neoplasm Of Salivary Gland

Salivary Gland Neoplasms
Brain Malformations With Or Without Urinary Tract Defects

Chromosome 1p32-P31 Deletion Syndrome

Nfia-Related Disorder

Chromosome 1, Monosomy 1p32

BRMUTD

1p31p32 Microdeletion Syndrome

Nfia Haploinsufficiency

Del(1)(P31p32)

Monosomy 1p31p32

Nfia-Related Disorders
Salivary Gland Adenoid Cystic Carcinoma

Cylindroma
Infiltrating Lipoma

Intramuscular Lipoma
Epithelial-Myoepithelial Carcinoma

Clear Cell Adenoma

Adenomyo-Epithelioma

Clear Cell Carcinoma

Emc

Epithelial Myoepithelial Carcinoma

Glycogen-Rich Adenocarcinoma

Glycogen-Rich Adenoma

Monomorphic Clear Cell Tumor

Tubular Solid Adenoma

Adenocarcinoma, Clear Cell
Lacrimal Gland Carcinoma

Lacrimal Gland Cancer

Carcinoma Of The Lacrimal Gland

Malignant Neoplasm Of Lacrimal Gland

Malignant Tumour Of Lacrimal Gland

Neoplasm Of Lacrimal Gland

Tumor Of The Lacrimal Gland

Malignant Tumor Of Lacrimal Gland
Bartholin'S Gland Adenoid Cystic Carcinoma

Bartholin Gland Adenoid Cystic Carcinoma
Cervical Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of The Cervix Uteri
Spiradenoma

Eccrine Spiradenoma

Benign Eccrine Spiradenoma

Eccrine Spiradenoma Of Skin

Es

Eccrine Spiradenoma, Benign
Pleomorphic Adenoma Carcinoma

Carcinoma Ex Pleomorphic Adenoma

Carcinoma In Pleomorphic Adenoma
Marshall-Smith Syndrome

MRSHSS

Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome

Mss
Lipoma Of Colon

Colonic Lipoma

Colon Lipoma
Large Intestine Lipoma

Lipoma Of Large Intestine

Colorectal Lipoma
Mammary Analogue Secretory Carcinoma
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Microglandular Adenosis

Breast Fibrocystic Disease

Adenosis - Breast

Adenosis Of The Breast

Fibrocystic Breast Disease

Breast Adenosis

Adenosis Of Breast
Salivary Gland Disease

Salivary Gland Disorders

Salivary Gland Diseases

Non-Neoplastic Salivary Gland Disease

Non-Neoplastic Salivary Gland Disorder

Disorder Of Salivary Gland

Lesion Of Salivary Gland Nos
Breast Secretory Carcinoma

Secretory Breast Carcinoma

Juvenile Breast Carcinoma

Juvenile Carcinoma Of The Breast

Juvenile Secretory Carcinoma Of Breast

Juvenile Breast Cancer

Sbc

Secretory Carcinoma Of The Breast
Brooke-Spiegler Syndrome

Cyld Cutaneous Syndrome

Spiegler-Brooke Syndrome

Familial Cylindromatosis

BRSS

Bss

Sbs

Multiple Familial Trichoepithelioma

Ancell-Spiegler Cylindromas

Familial Multiple Trichoepithelioma

Trichoepithelioma

Fc

Mft

Multiple Familial Trichoepitheliomas

Ccs

Turban Tumor Syndrome

Schilbach-Rott Syndrome

Eccrine Dermal Cylindroma

Familial Multiple Trichoepitheliomata
Keratoconus

Kc

Conical Cornea

Noninflammatory Corneal Thining

Bulging Cornea

Cornea Conical

Acquired Conus Of Cornea
Cribriform Carcinoma

Ductal Carcinoma, Cribriform Type

Carcinoma Cribriform

Carcinoma, Cribriform
Lacrimal Gland Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Lacrimal Gland
Lacrimal Gland Adenocarcinoma

Adenocarcinoma Of Lacrimal Gland
Lacrimal System Cancer

Neoplasm Of Lacrimal System

Lacrimal System Neoplasm

Tumor Of The Lacrimal System
Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma
Acinar Cell Carcinoma

Acinic Cell Carcinoma

Acinic Cell Tumor

Carcinoma Acinar Cell

Carcinoma, Acinar Cell

Acinar Cell Tumor
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
Apocrine Sweat Gland Neoplasm

Apocrine Tumor

Apocrine Neoplasm
Anus Basaloid Carcinoma

Basaloid Carcinoma Of The Anus

Anal Basaloid Carcinoma
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09250 NFIB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NFIB MGD MGI:103188
Felis catus NFIB VGNC VGNC:82494
Macaca mulatta NFIB VGNC VGNC:75335
Rattus norvegicus NFIB RGD RGD:62015
Bos taurus NFIB VGNC VGNC:32039
Canis familiaris NFIB VGNC VGNC:43776
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