2. Gene
  3. NFIC - nuclear factor I C Gene

NFIC - nuclear factor I C Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核因子 IC

种属: Homo sapiens

同用名: CTF; NFI; CTF5; NF-I

基因 ID: 4782 | 基因类型: protein coding

关于 NFIC

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,359,630-3,469,217 (from NCBI)

This gene has 11 transcripts (splice variants), 124 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 22.7), ovary (RPKM 18.1) and 25 other tissues.

功能概要

该基因编码的蛋白质属于 CTF/NF-I 家族。这些是二聚体 DNA 结合蛋白，可作为细胞转录因子和腺病毒 DNA 复制的复制因子。已经针对该基因描述了编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

NFIC 基因产物(5)

mRNA Protein Name
NM_001245002.2 NP_001231931.1 nuclear factor 1 C-type isoform 1
NM_001245004.2 NP_001231933.1 nuclear factor 1 C-type isoform 3
NM_001245005.2 NP_001231934.1 nuclear factor 1 C-type isoform 4
NM_005597.4 NP_005588.2 nuclear factor 1 C-type isoform 5
NM_205843.3 NP_995315.1 nuclear factor 1 C-type isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
1524678 GOA
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
1524678 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
1524678 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24145797 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19706729 GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
1524678 GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
1524678 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19706729 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NFIC 蛋白结构

NfI_DNAbd_pre-N

NfI_DNAbd_pre-N: Nuclear factor I protein pre-N-terminus (5 - 47)

MH1

MH1: MH1 domain (70 - 170)

CTF_NFI

CTF_NFI: CTF/NF-I family transcription modulation region (217 - 508)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
蛋白主名 其他名称

nuclear factor 1 C-type

CCAAT-box-binding transcription factor

NFIC 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NFIC P08651 NFIB Homo sapiens O00712
Affinity Chrom
35140242
种属内
NFIC P08651 NFIB Homo sapiens O00712
Anti Tag CoIP
25258084
种属内
NFIC P08651 NFIB Homo sapiens O00712
BioID
35140242
种属内
NFIC P08651 PARP1 Homo sapiens P09874
Anti Bait CoIP
24145797
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mechanical Ectropion
Marshall-Smith Syndrome

MRSHSS

Accelerated Skeletal Maturation-Facial Dysmorphism-Failure To Thrive Syndrome

Mss
Neurofibrosarcoma

Neurosarcoma

Malignant Peripheral Nerve Sheath Tumor
Plexiform Neurofibroma

Neurofibroma Plexiform

Neurofibroma, Plexiform
Optic Nerve Glioma

Glioma Of The Optic Nerve
Blount'S Disease

Blount Disease

Tibia Vara

Osteochondrosis Deformans Tibiae

Osteochondrosis Deformans Tibiae, Familial Infantile Type

Familial Infantile Type Osteochondrosis Deformans Tibiae

Blount-Barber Syndrome

Erlacher-Blount Syndrome

Infantile Tibia Vara

Tibia Vara Blount

Blount Disease, Infantile
Scrotum Neoplasm

Malignant Tumour Of Scrotum

Malignant Scrotal Neoplasm

Malignant Tumor Of Scrotum

Neoplasm Of Scrotum

Scrotal Ca

Scrotal Tumor

Scrotum Cancer

Cancer Of Scrotum

Malignant Neoplasm Of Scrotum

Scrotal Cancer

Malignant Scrotal Tumour

Malignant Neoplasm Of Skin Of Scrotum

Primary Malignant Neoplasm Of Scrotum
Optic Nerve Neoplasm

Optic Nerve Neoplasms

Neoplasm Of Optic Nerve

Tumor Of Second Cranial Nerve

Tumour Of Optic Nerve
Neurofibromatosis, Type I

Von Recklinghausen Disease

Neurofibromatosis 1

Neurofibromatosis, Type 1

NF1

Neurofibromatosis, Peripheral Type

Neurofibromatosis Type I

Neurofibromatosis Type 1 Due To Nf1 Mutation Or Intragenic Deletion

Familial Spinal Neurofibromatosis

Fsnf

Peripheral Neurofibromatosis

Von Recklinghausen'S Neurofibromatosis

Von Recklinghausen Disease Due To Nf1 Mutation Or Intragenic Deletion

Neurofibromatosis Peripheral Type

Von Recklinghausen Syndrome

Neurofibromatosis Type 1

Von Recklinghausen Neuropathy

Nf1 - [Neurofibromatosis Type 1]

Recklinghausen Disease
Elephantiasis
Peripheral Nervous System Disease

Peripheral Neuropathy

Peripheral Nerve Disease

Peripheral Nerve Disorders

Neuropathy, Peripheral

Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09251 NFIC Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta NFIC VGNC VGNC:75336
Rattus norvegicus NFIC RGD RGD:62016
Felis catus NFIC VGNC VGNC:80638
Canis familiaris NFIC VGNC VGNC:43777
Bos taurus NFIC VGNC VGNC:32040
Mus musculus NFIC MGD MGI:109591
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