1. Gene
  2. NHLH2 - nescient helix-loop-helix 2 Gene

NHLH2 - nescient helix-loop-helix 2 Gene

中文名称:新生螺旋-环-螺旋 2

种属: Homo sapiens

同用名: HEN2; HH27; NSCL2; bHLHa34

基因 ID: 4808 | 基因类型: protein coding

关于 NHLH2

Cytogenetic location: 1p13.1 Genomic coordinates (GRCh38): 1:115,831,344-115,841,126 (from NCBI)

This gene has 3 transcripts (splice variants), 104 orthologues, 4 paralogues and is associated with 1 phenotype. Low expression observed in reference dataset.

功能概要

启用 RNA 聚合酶 II 特异性 DNA 结合转录因子结合活性和序列特异性双链 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预计在细胞凋亡过程的上游或内部发挥积极作用;下丘脑促性腺激素释放激素神经元发育;和周围神经系统发育。预计在多个过程的上游或内部起作用,包括后脑中的细胞迁移;男性性腺发育;和雄性交配行为。预测位于核内。预测是染色质的一部分。 [由基因组资源联盟提供,2022 年 4 月]

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within with a positive effect on apoptotic process; hypothalamus gonadotrophin-releasing hormone neuron development; and peripheral nervous system development. Predicted to act upstream of or within several processes, including cell migration in hindbrain; male gonad development; and male mating behavior. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

NHLH2 基因产物(2)

mRNA Protein Name
NM_001111061.2 NP_001104531.1 helix-loop-helix protein 2
NM_005599.3 NP_005590.1 helix-loop-helix protein 2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
16314316 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22169038 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NHLH2 蛋白结构

HLH

HLH: Helix-loop-helix DNA-binding domain (79 - 129)

  • 0
  • 100
  • 135 a.a.
蛋白主名 其他名称

helix-loop-helix protein 2

HEN-2

NHLH2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra NHLH2 Q02577 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra NHLH2 Q02577 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra NHLH2 Q02577 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra NHLH2 Q02577 TCF4 Homo sapiens P15884-3
Y2H Array
32296183
Intra NHLH2 Q02577 TCF4 Homo sapiens P15884-3
Y2H Prey Pooling
32296183
Intra NHLH2 Q02577 MYF5 Homo sapiens P13349
Y2H Array
32296183
Intra NHLH2 Q02577 MYF5 Homo sapiens P13349
Y2H Prey Pooling
32296183
Intra NHLH2 Q02577 SIRT1 Homo sapiens Q96EB6
Anti Tag CoIP
22169038
Intra NHLH2 Q02577 KCNIP1 Homo sapiens Q9NZI2-2
Y2H Prey Pooling
32296183
Intra NHLH2 Q02577 KCNIP1 Homo sapiens Q9NZI2-2
Validated Y2H
32296183
Intra NHLH2 Q02577 KCNIP1 Homo sapiens Q9NZI2-2
Y2H Array
32296183
Intra NHLH2 Q02577 TAF1D Homo sapiens Q9H5J8
Y2H Array
32296183
Intra NHLH2 Q02577 TAF1D Homo sapiens Q9H5J8
Y2H Prey Pooling
32296183
Intra NHLH2 Q02577 TAF1D Homo sapiens Q9H5J8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hypogonadotropic Hypogonadism 27 Without Anosmia

HH27

Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus NHLH2 RGD RGD:1308294
Felis catus NHLH2 VGNC VGNC:107590
Bos taurus NHLH2 VGNC VGNC:32066
Mus musculus NHLH2 MGD MGI:97324
Canis familiaris NHLH2 VGNC VGNC:43799
Macaca mulatta NHLH2 VGNC VGNC:106417