1. Gene
  2. NPY2R - neuropeptide Y receptor Y2 Gene

NPY2R - neuropeptide Y receptor Y2 Gene

中文名称:神经肽 Y 受体 Y2

种属: Homo sapiens

同用名: NPY2-R

基因 ID: 4887 | 基因类型: protein coding

关于 NPY2R

Cytogenetic location: 4q32.1 Genomic coordinates (GRCh38): 4:155,173,723-155,217,076 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues and 33 paralogues. Low expression observed in reference dataset.

功能概要

预测可启用钙通道调节剂活性和神经肽 Y 受体活性。参与心脏左心室形态发生和流出道形态发生。位于纤毛。与亨廷顿病有关;病态肥胖;和肥胖。外周动脉疾病和颞叶癫痫的生物标志物。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable Calcium Channel regulator activity and Neuropeptide Y Receptor activity. Involved in cardiac left ventricle morphogenesis and outflow tract morphogenesis. Located in cilium. Implicated in Huntington's disease; morbid obesity; and obesity. Biomarker of peripheral artery disease and temporal lobe epilepsy. [provided by Alliance of Genome Resources, Apr 2022]

NPY2R 基因产物(3)

mRNA Protein Name
NM_001375470.1 NP_001362399.1 neuropeptide Y receptor type 2
NM_001370180.1 NP_001357109.1 neuropeptide Y receptor type 2
NM_000910.4 NP_000901.1 neuropeptide Y receptor type 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
23597562 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac left ventricle morphogenesis IMP
IMP: 通过突变表型推断
19593212 GOA
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
19593212 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cilium IDA
IDA: 通过直接分析推断
28154160 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

NPY2R 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (67 - 325)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
蛋白主名 其他名称

neuropeptide Y receptor type 2

NPY-Y2 receptor

NPY2R 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NPY2R P49146 PYY Homo sapiens P10082
SPA
23597562
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephronophthisis 4

NPHP4

Juvenile Nephronophthisis 4

Nephronophthisis 4, Juvenile

Nephronophthisis, Type 4

Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders

Peripheral Artery Disease

Peripheral Arterial Disease

Peripheral Arterial Diseases

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome

Huntington Disease

Huntington'S Disease

Huntington Chorea

HD

Huntington'S Chorea

Huntington Chronic Progressive Hereditary Chorea

Juvenile Huntington Disease

Chronic Progressive Chorea

Chronic Progressive Hereditary Chorea

Hc - [Huntington Chorea]

Hereditary Chorea

Progressive Hereditary Chorea

Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus NPY2R MGD MGI:108418
Rattus norvegicus NPY2R RGD RGD:620475
Felis catus NPY2R VGNC VGNC:78538
Macaca mulatta NPY2R VGNC VGNC:100257
Bos taurus NPY2R VGNC VGNC:52806
Others NPY2R NCBI