2. Gene
  3. OGN - osteoglycin Gene

OGN - osteoglycin Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：骨多糖

种属: Homo sapiens

同用名: OG; OIF; SLRR3A

基因 ID: 4969 | 基因类型: protein coding

关于 OGN

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,383,268-92,404,699 (from NCBI)

This gene has 4 transcripts (splice variants), 260 orthologues and 10 paralogues. Broad expression in gall bladder (RPKM 88.2), endometrium (RPKM 64.5) and 14 other tissues.

功能概要

该基因编码富含亮氨酸的小蛋白多糖 (SLRP) 蛋白质家族的成员。编码的蛋白质与转化生长因子 β 一起诱导异位骨形成，并可能调节成骨细胞分化。编码蛋白的高表达可能与心脏左心室质量升高有关。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family of proteins. The encoded protein induces ectopic bone formation in conjunction with transforming growth factor beta and may regulate osteoblast differentiation. High expression of the encoded protein may be associated with elevated heart left ventricular mass. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

OGN 基因产物(3)

mRNA Protein Name
NM_014057.5 NP_054776.1 mimecan isoform 2 precursor
NM_024416.4 NP_077727.3 mimecan isoform 1
NM_033014.4 NP_148935.1 mimecan isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17474147 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

OGN 蛋白结构

LRR_8

LRR_8: Leucine rich repeat (123 - 179)

  • 0
  • 100
  • 200
  • 298 a.a.
蛋白主名 其他名称

mimecan

corneal keratan sulfate proteoglycan

重组 OGN 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74664 OGN/Osteoglycin Protein, Human (HEK293, His) P20774 (P21-F298) ≥95%

关联疾病

疾病名称 别名
Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder
Adjustment Disorder

Adjustment Reaction

Adjustment Disorders

Adjustment Disease

Brief Situational Non-Psychotic Disorder

Adaptation Reaction Nos

Emotional Crisis

Situational Disorder

Situational Disturbance

Situational Maladjustment

Situational Reaction

Situational Reaction With Maladjustment

Transient Situational Disturbance
Combat Disorder

Combat Disorders

Combat Neurosis
Plantar Fascial Fibromatosis

Dupuytren'S Contracture Of Foot

Ledderhose'S Disease

Fibromatosis, Plantar

Ledderhose Disease
Post-Traumatic Stress Disorder

PTSD

Traumatic Neurosis

Post Traumatic Stress Disorder

Stress Disorders, Post-Traumatic

Posttraumatic Stress Disorder

Ptsd - [Post Traumatic Stress Disorder]

Trauma-Related Disorders
Dissociative Amnesia

Psychogenic Amnesia

Amnesia, Dissociative

Amnesia, Psychogenic

Amnesia Neurosis

Hysterical Fugue

Dissociative Fugue
Dissociative Disorder

Dissociative Disorders

Dissociative Disease

Dissociative Reaction
Psammomatous Meningioma
Acute Stress Disorder

Traumatic Stress Disorder

Stress Disorders, Traumatic, Acute

Stress Disorders, Traumatic
Macular Dystrophy, Corneal

Macular Corneal Dystrophy

MCD

Corneal Dystrophy, Macular Type

Groenouw Type Ii Corneal Dystrophy

Fehr Corneal Dystrophy

Macular Dystrophy, Corneal Type 1

Mcdc1

Macular Corneal Dystrophy Type Ii

Macular Corneal Dystrophy, Type Ii

Macular Corneal Dystrophy, Type I

Mcdc1, Formerly

Macular Dystrophy, Corneal, 1

Macular Corneal Dystrophy Type 1

Corneal Dystrophy Groenouw Type Ii

Corneal Dystrophy Macular Type

Macular Corneal Dystrophy Type I

Dystrophy, Macular, Corneal
Vaginal Cancer

Malignant Neoplasm Of Vagina

Vaginal Neoplasms

Malignant Tumor Of Vagina

Malignant Vaginal Tumor

Neoplasm Of Vagina

Vagina Neoplasm

Vaginal Tumor

Vaginal Carcinoma

Vaginal Malignant Epithelial Tumor

Vaginal Neoplasm

Malignant Vaginal Neoplasm

Vagina Carcinoma

Vaginal Neoplasia

Cancer Of Vagina

Malignant Tumour Of Vagina

Carcinoma Of Vagina

Primary Malignant Neoplasm Of Vagina

Vagina Wall Cancer

Vaginal Wall Cancer
Multiple Personality Disorder

Dissociative Identity Disorder

Multiple Personality
Cornea Plana

Flat Cornea
Amnestic Disorder

Amnesia

Amnestic Syndrome

Korsakoff'S Psychosis Or Syndrome

Amnesic Syndrome

Amnestic Disorder In Conditions Classified Elsewhere

Korsakoff Psychosis Or Syndrome, Nonalcoholic

Nonalcoholic Organic Amnesic Syndrome

Organic Amnesic Syndrome
Substance Abuse

Substance-Related Disorders

Substance Abuse Problem
Alcohol Use Disorder

Alcohol Abuse

Alcoholism

Ethanol Abuse

Alcohol Addiction

Alcohol Dependence

Alcoholic Intoxication, Chronic

Alcohol-Related Disorders
Stromal Dystrophy
Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09764 OGN Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris OGN VGNC VGNC:44110
Rattus norvegicus OGN RGD RGD:1308171
Felis catus OGN VGNC VGNC:68622
Mus musculus OGN MGD MGI:109278
Macaca mulatta OGN VGNC VGNC:75582
Bos taurus OGN VGNC VGNC:32414
Others OGN NCBI
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