OPRL1 - opioid related nociceptin receptor 1 Gene

中文名称：阿片类药物相关伤害感受素受体 1

种属: Homo sapiens

同用名: NOP; OOR; KOR3; NOPr; OPRL; ORL1; KOR-3; NOCIR; PNOCR

关于 OPRL1

功能概要

由该基因编码的蛋白质是 7 个跨膜 G 蛋白偶联受体家族的成员，作为内源性阿片类药物相关神经肽痛敏肽/孤啡肽 FQ 的受体发挥作用。这种受体-配体系统调节多种生物学功能和神经行为，包括应激反应和焦虑行为、学习和记忆、运动活动以及炎症和免疫反应。该基因与相反链上 5'-相邻 RGS19 (G 蛋白信号转导 19 的调节因子) 基因之间的启动子区域作为两个基因的核心启动子双向发挥作用，表明这两个基因在功能上协同转录调控相关基因。已经描述了该基因的可变剪接转录物变体。最近的一项研究为该基因的翻译通读提供了证据，并通过使用替代的框内翻译终止密码子表达了额外的 C 末端扩展同种型。[RefSeq 提供，2017 年 12 月]

The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]