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  3. Kdm1a - lysine demethylase 1A Gene

Kdm1a - lysine demethylase 1A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：赖氨酸脱甲基酶 1A

种属: Rattus norvegicus

同用名: Aof2; Kdm1; RGD1562975

基因 ID: 500569 | 基因类型: protein coding

关于 Kdm1a

Primary_assembly 5: 148,782,976-148,838,319 reverse strand.mRatBN7.2:CM026978.1

This gene has 3 transcripts (splice variants), 215 orthologues, 10 paralogues and is associated with 19 phenotypes. Biased expression in Thymus (RPKM 19.), Brain (RPKM 146.9) and 9 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性。参与多个过程，包括对 cAMP 的细胞反应；神经系统发育；和对杀菌剂的反应。位于染色质和细胞核中。乳腺癌生物标志物；糖尿病性视网膜病变;精神分裂症;和短暂性脑缺血。与人 KDM1A（赖氨酸脱甲基酶 1A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity. Involved in several processes, including cellular response to cAMP; nervous system development; and response to fungicide. Located in chromatin and nucleus. Biomarker of breast cancer; diabetic retinopathy; schizophrenia; and transient cerebral ischemia. Orthologous to human KDM1A (lysine demethylase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Kdm1a 基因产物(1)

mRNA Protein Name
NM_001130098.1 NP_001123570.1 lysine-specific histone demethylase 1A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables chromatin binding IDA
IDA: 通过直接分析推断
23221071 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
24227653 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
20418916 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
20164337 RGD
involved in guanine metabolic process IMP
IMP: 通过突变表型推断
20418916 RGD
involved in neuron maturation IEP
IEP: 通过表达模式推断
20164337 RGD
involved in positive regulation of cell size IMP
IMP: 通过突变表型推断
20164337 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
20164337 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20418916 RGD
involved in protein modification process IEP
IEP: 通过表达模式推断
23221071 RGD
involved in protein modification process IMP
IMP: 通过突变表型推断
20418916 RGD
involved in response to fungicide IEP
IEP: 通过表达模式推断
22496781 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
22496781 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
23221071 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Kdm1a 蛋白结构

PHA03378

PHA03378: cl33729 (37 - 97)

PLN02328

PLN02328: cl33466 (202 - 848)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 876 a.a.
蛋白主名 其他名称

lysine-specific histone demethylase 1A

amine oxidase (flavin containing) domain 2

lysine (K)-specific demethylase 1

lysine (K)-specific demethylase 1A

neuroprotective protein 3

相关产品

Clinical Phase
生物活性分子 (6)
目录号 产品名 作用方式
纯度 Phase
HY-18632 GSK2879552 Inhibitor 99.90% Phase 2
HY-103713 Seclidemstat Inhibitor 99.77% Phase 2
HY-18632A GSK2879552 dihydrochloride Inhibitor 99.19% Phase 2
HY-109117 Iadademstat Inhibitor 99.61% Phase 2
HY-12782T Iadademstat dihydrochloride Inhibitor 99.83% Phase 1
HY-138830 TAK-418 Inhibitor 99.10% Phase 1
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103713A Seclidemstat mesylate Inhibitor 99.60% 否
HY-19612B DDP-38003 trihydrochloride Inhibitor / 否
HY-19612A DDP-38003 dihydrochloride Inhibitor 98.22% 否
HY-112304 NCD38 TFA Inhibitor / 否
HY-112304A (1R,2S)-NCD38 TFA Inhibitor / 否
HY-143238 FY-56 Inhibitor / 否
HY-RS07205 KDM1A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07206 Kdm1a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS07207 Kdm1a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kdm1a NCBI NCBI:23028
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