2. Gene
  3. DCTN4 - dynactin subunit 4 Gene

DCTN4 - dynactin subunit 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：动力蛋白亚基 4

种属: Homo sapiens

同用名: P62; DYN4

基因 ID: 51164 | 基因类型: protein coding

关于 DCTN4

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:150,708,440-150,759,017 (from NCBI)

This gene has 15 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 24.6), bone marrow (RPKM 19.3) and 25 other tissues.

功能概要

启用蛋白质 N 末端结合活性。位于中心体。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein N-terminus binding activity. Located in centrosome. [provided by Alliance of Genome Resources, Apr 2022]

DCTN4 基因产物(3)

mRNA Protein Name
NM_001135643.2 NP_001129115.1 dynactin subunit 4 isoform a
NM_001135644.2 NP_001129116.1 dynactin subunit 4 isoform c
NM_016221.4 NP_057305.1 dynactin subunit 4 isoform b
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16554302 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCTN4 蛋白结构

Dynactin_p62

Dynactin_p62: Dynactin p62 family (23 - 126)

Dynactin_p62

Dynactin_p62: Dynactin p62 family (138 - 425)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 460 a.a.
蛋白主名 其他名称

dynactin subunit 4

dynactin 4 (p62)

DCTN4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra DCTN4 Q9UJW0 ACTR10 Homo sapiens Q9NZ32
Y2H Array
32296183
Intra DCTN4 Q9UJW0 ACTR10 Homo sapiens Q9NZ32
Y2H Prey Pooling
32296183
Intra DCTN4 Q9UJW0 PNMA1 Homo sapiens Q8ND90
Validated Y2H
25416956
Intra DCTN4 Q9UJW0 PNMA1 Homo sapiens Q8ND90
Y2H Array
25416956
Intra DCTN4 Q9UJW0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
26871637
Intra DCTN4 Q9UJW0 GOLGA2 Homo sapiens Q08379
Validated Y2H
26871637
Intra DCTN4 Q9UJW0 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra DCTN4 Q9UJW0 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra DCTN4 Q9UJW0 GOLGA2 Homo sapiens Q08379
Y2H Array
26871637
Intra DCTN4 Q9UJW0 GOLGA2 Homo sapiens Q08379
Y2H
21516116
Intra DCTN4 Q9UJW0 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra DCTN4 Q9UJW0 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra DCTN4 Q9UJW0 MTUS2 Homo sapiens Q5JR59
Y2H Prey Pooling
25416956
Intra DCTN4 Q9UJW0 MTUS2 Homo sapiens Q5JR59
Y2H
21516116
Intra DCTN4 Q9UJW0 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Autosomal Dominant Nonsyndromic Deafness 77

Dfna77
Alzheimer'S Disease 1

Alzheimer Disease Type 1

Alzheimer'S Disease 1, Early Onset
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03595 DCTN4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta DCTN4 VGNC VGNC:71625
Felis catus DCTN4 VGNC VGNC:61380
Mus musculus DCTN4 MGD MGI:1914915
Bos taurus DCTN4 VGNC VGNC:27931
Canis familiaris DCTN4 VGNC VGNC:39819
Rattus norvegicus DCTN4 RGD RGD:71023
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