2. Gene
  3. DCXR - dicarbonyl and L-xylulose reductase Gene

DCXR - dicarbonyl and L-xylulose reductase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：二羰基和 L-木酮糖还原酶

种属: Homo sapiens

同用名: XR; DCR; HCR2; P34H; HCRII; KIDCR; PNTSU; SDR20C1

基因 ID: 51181 | 基因类型: protein coding

关于 DCXR

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:82,035,858-82,037,697 (from NCBI)

This gene has 21 transcripts (splice variants), 186 orthologues and is associated with 2 phenotypes. Biased expression in liver (RPKM 345.1), kidney (RPKM 158.4) and 7 other tissues.

功能概要

由该基因编码的蛋白质作为同源四聚体催化二乙酰还原酶和 L-木酮糖还原酶反应。编码的蛋白质可能在葡萄糖代谢的糖酸盐循环和近端肾小管的细胞渗透压调节中发挥作用。该基因的缺陷是戊尿症的一个原因。已为该基因发现编码不同亚型的两个转录变体。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene acts as a homotetramer to catalyze diacetyl reductase and L-xylulose reductase reactions. The encoded protein may play a role in the uronate cycle of glucose metabolism and in the cellular osmoregulation in the proximal renal tubules. Defects in this gene are a cause of pentosuria. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2010]

DCXR 基因产物(2)

mRNA Protein Name
NM_001195218.1 NP_001182147.1 L-xylulose reductase isoform 2
NM_016286.4 NP_057370.1 L-xylulose reductase isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables L-xylulose reductase (NADPH) activity IDA
IDA: 通过直接分析推断
11882650 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor IDA
IDA: 通过直接分析推断
19442656 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in glucose metabolic process IDA
IDA: 通过直接分析推断
11882650 GOA
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: 通过直接分析推断
19442656 GOA
involved in xylulose metabolic process IDA
IDA: 通过直接分析推断
11882650 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasmic microtubule IDA
IDA: 通过直接分析推断
23264731 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCXR 蛋白结构

adh_short_C2

adh_short_C2: Enoyl-(Acyl carrier protein) reductase (16 - 241)

  • 0
  • 100
  • 200
  • 244 a.a.
蛋白主名 其他名称

L-xylulose reductase

carbonyl reductase 2

重组 DCXR 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70082 L-xylulose reductase/DCXR Protein, Human (His) Q7Z4W1 (M1-C244) ≥95%

关联疾病

疾病名称 别名
Pentosuria

Xylitol Dehydrogenase Deficiency

L-Xylulosuria

L-Xylulose Reductase Deficiency

Essential Pentosuria

PNTSU

Essential Benign Pentosuria
Erythrasma

Infection Due To Corynebacterium Minutissimum
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03602 DCXR Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus DCXR MGD MGI:1915130
Canis familiaris DCXR VGNC VGNC:39825
Felis catus DCXR VGNC VGNC:98907
Rattus norvegicus DCXR RGD RGD:620031
Macaca mulatta DCXR VGNC VGNC:71669
Others DCXR NCBI
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