1. Gene
  2. CLEC1A - C-type lectin domain family 1 member A Gene

CLEC1A - C-type lectin domain family 1 member A Gene

中文名称:C 型凝集素结构域家族 1 成员 A

种属: Homo sapiens

同用名: CLEC1; CLEC-1

基因 ID: 51267 | 基因类型: protein coding

关于 CLEC1A

Cytogenetic location: 12p13.2 Genomic coordinates (GRCh38): 12:10,069,554-10,098,985 (from NCBI)

This gene has 5 transcripts (splice variants), 370 orthologues, 23 paralogues and is associated with 1 phenotype. Biased expression in placenta (RPKM 18.1), lung (RPKM 3.8) and 10 other tissues.

功能概要

该基因编码 C 型凝集素/C 型凝集素样结构域 (CTL/CTLD) 超家族的成员。该家族的成员具有共同的蛋白质折叠并具有多种功能,例如细胞粘附、细胞间信号传导、糖蛋白更新以及在炎症和免疫反应中的作用。编码的蛋白质可能在调节树突状细胞功能中发挥作用。该基因与自然杀伤基因复合区 12p13 染色体上的其他 CTL/CTLD 超家族成员密切相关。可变剪接导致多个转录本变体。[RefSeq 提供,2014 年 7 月]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. This gene is closely linked to Other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

CLEC1A 基因产物(5)

mRNA Protein Name
NM_001297748.2 NP_001284677.1 C-type lectin domain family 1 member A isoform b
NM_001297749.2 NP_001284678.1 C-type lectin domain family 1 member A isoform c
NM_001297750.2 NP_001284679.1 C-type lectin domain family 1 member A isoform d
NM_001297751.2 NP_001284680.1 C-type lectin domain family 1 member A isoform d
NM_016511.4 NP_057595.2 C-type lectin domain family 1 member A isoform a
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CLEC1A 蛋白结构

Lectin_C

Lectin_C: Lectin C-type domain (155 - 259)

  • 0
  • 100
  • 200
  • 280 a.a.
蛋白主名 其他名称

C-type lectin domain family 1 member A

C-type lectin-like receptor-1

CLEC1A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CLEC1A Q8NC01 LRRC25 Homo sapiens Q8N386
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 LRRC25 Homo sapiens Q8N386
Y2H Array
32296183
种属内
CLEC1A Q8NC01 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
种属内
CLEC1A Q8NC01 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
种属内
CLEC1A Q8NC01 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
种属内
CLEC1A Q8NC01 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
种属内
CLEC1A Q8NC01 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 CLEC12A Homo sapiens Q5QGZ9
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 CLEC12A Homo sapiens Q5QGZ9
Y2H Array
32296183
种属内
CLEC1A Q8NC01 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
种属内
CLEC1A Q8NC01 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
种属内
CLEC1A Q8NC01 GJA8 Homo sapiens P48165
Y2H Array
32296183
种属内
CLEC1A Q8NC01 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
种属内
CLEC1A Q8NC01 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
种属内
CLEC1A Q8NC01 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
种属内
CLEC1A Q8NC01 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 FFAR2 Homo sapiens O15552
Y2H Array
32296183
种属内
CLEC1A Q8NC01 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
种属内
CLEC1A Q8NC01 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
种属内
CLEC1A Q8NC01 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 STX1A Homo sapiens Q16623
Y2H Array
32296183
种属内
CLEC1A Q8NC01 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 MRPS18B Homo sapiens Q9Y676
Y2H Array
32296183
种属内
CLEC1A Q8NC01 MRPS18B Homo sapiens Q9Y676
Y2H Prey Pooling
32296183
种属内
CLEC1A Q8NC01 MRPS18B Homo sapiens Q9Y676
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CLEC1A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75338 CLEC-1/CLEC1A Protein, Human (HEK293, Fc) Q8NC01/NP_057595.2 (Q77-D280) ≥95%

关联疾病

疾病名称 别名
Aspergillosis

Aspergillosis, Susceptibility To

Infection Due To Aspergillus

Aspergilloma

Aspergillus Nodule

Simple Aspergilloma

Aspergillus

Aspergillus Flavus Infection

Aspergillus Fumigatus Infection

Aspergillus Infection

Infection By Aspergillus Fumigatus

Intracavitary Aspergillus Fungus Ball

Aspergillus Terreus

Glioblastoma Proneural Subtype
White Piedra

Tinea Blanca

Trichosporosis Nodosa

Autoimmune Atherosclerosis
Subcutaneous Mycosis

Subcutaneous Fungal Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CLEC1A VGNC VGNC:71335
Bos taurus CLEC1A VGNC VGNC:27427
Mus musculus CLEC1A MGD MGI:2444151
Rattus norvegicus CLEC1A RGD RGD:1566110
Felis catus CLEC1A VGNC VGNC:83534
Others CLEC1A NCBI