2. Gene
  3. ZBTB7A - zinc finger and BTB domain containing 7A Gene

ZBTB7A - zinc finger and BTB domain containing 7A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含锌指和 BTB 结构域 7A

种属: Homo sapiens

同用名: LRF; FBI1; FBI-1; TIP21; ZBTB7; MNDLFH; ZNF857A; pokemon

基因 ID: 51341 | 基因类型: protein coding

关于 ZBTB7A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,043,303-4,066,899 (from NCBI)

This gene has 2 transcripts (splice variants), 114 orthologues, 4 paralogues and is associated with 2 phenotypes. Ubiquitous expression in colon (RPKM 8.0), stomach (RPKM 5.5) and 25 other tissues.

功能概要

启用多项功能，包括 SMAD 绑定活动；雄激素受体结合活性；和转录辅阻遏物结合活性。参与几个过程，包括红细胞成熟；信号转导的负调控；和调节含核碱基的化合物代谢过程。位于细胞质和细胞核中。与 DNA 依赖性蛋白激酶复合物和 NuRD 复合物共定位。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including SMAD binding activity; Androgen Receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with DNA-dependent protein kinase complex and NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]

ZBTB7A 基因产物(2)

mRNA Protein Name
NM_001317990.2 NP_001304919.1 zinc finger and BTB domain-containing protein 7A
NM_015898.4 NP_056982.1 zinc finger and BTB domain-containing protein 7A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
17595526 GOA
enables DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
12004059 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IMP
IMP: 通过突变表型推断
26455326 GOA
enables SMAD binding IDA
IDA: 通过直接分析推断
25514493 GOA
enables SMAD binding IPI
IPI: 通过物理相互作用推断
25514493 GOA
enables nuclear androgen receptor binding IDA
IDA: 通过直接分析推断
20812024 GOA
enables nuclear androgen receptor binding IPI
IPI: 通过物理相互作用推断
20812024 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15917220 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
enables transcription corepressor binding IDA
IDA: 通过直接分析推断
20812024 GOA
enables transcription corepressor binding IPI
IPI: 通过物理相互作用推断
20812024 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromatin remodeling IMP
IMP: 通过突变表型推断
26816381 GOA
involved in erythrocyte maturation IMP
IMP: 通过突变表型推断
26816381 GOA
involved in fat cell differentiation IMP
IMP: 通过突变表型推断
14701838 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12004059 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
20812024 GOA
involved in negative regulation of androgen receptor signaling pathway IMP
IMP: 通过突变表型推断
20812024 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20812024 GOA
involved in negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: 通过突变表型推断
25514493 GOA
involved in positive regulation of NF-kappaB transcription factor activity IDA
IDA: 通过直接分析推断
15917220 GOA
involved in protein localization to nucleus IMP
IMP: 通过突变表型推断
15917220 GOA
involved in regulation of alternative mRNA splicing, via spliceosome IDA
IDA: 通过直接分析推断
24514149 GOA
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
24514149 GOA
involved in regulation of glycolytic process IMP
IMP: 通过突变表型推断
26455326 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
14701838 GOA
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
26455326 GOA
involved in regulation of transcription regulatory region DNA binding IDA
IDA: 通过直接分析推断
12004059 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
15917220 GOA
located in nucleus IDA
IDA: 通过直接分析推断
15917220 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZBTB7A 蛋白结构

BTB

BTB: BTB/POZ domain (24 - 130)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (399 - 420)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (425 - 449)

zf-H2C2_2

zf-H2C2_2: Zinc-finger double domain (452 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 584 a.a.
蛋白主名 其他名称

zinc finger and BTB domain-containing protein 7A

HIV-1 1st-binding protein 1

ZBTB7A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ZBTB7A O95365 HOMEZ Homo sapiens Q8IX15-3
Y2H Prey Pooling
25416956
种属内
ZBTB7A O95365 CHD8 Homo sapiens Q9HCK8
Anti Tag CoIP
26816381
种属内
ZBTB7A O95365 CHD8 Homo sapiens Q9HCK8
Y2H
26816381
种属内
ZBTB7A O95365 KHDRBS1 Homo sapiens Q07666
Pull Down
24514149
种属内
ZBTB7A O95365 KHDRBS1 Homo sapiens Q07666
Density Sedimentation
24514149
种属内
ZBTB7A O95365 KHDRBS1 Homo sapiens Q07666
Anti Tag CoIP
24514149
种属内
ZBTB7A O95365 KHDRBS1 Homo sapiens Q07666
Y2H
24514149
种属内
ZBTB7A O95365 HDAC1 Homo sapiens Q13547
Anti Bait CoIP
26816381
种属内
ZBTB7A O95365 CHD3 Homo sapiens Q12873
Anti Tag CoIP
26816381
种属内
ZBTB7A O95365 CHD3 Homo sapiens Q12873
Y2H
26816381
种属内
ZBTB7A O95365 GATAD2B Homo sapiens Q8WXI9
Anti Bait CoIP
26816381
种属内
ZBTB7A O95365 GATAD2B Homo sapiens Q8WXI9
Anti Tag CoIP
26816381
种属内
ZBTB7A O95365 GATAD2B Homo sapiens Q8WXI9
Y2H
26816381
种属内
ZBTB7A O95365 BAZ1A Homo sapiens Q9NRL2
Y2H
26816381
种属内
ZBTB7A O95365 BAZ1A Homo sapiens Q9NRL2
Anti Tag CoIP
26816381
种属间: 跨种属相互作用 种属内: 同种属相互作用

ZBTB7A 抗体

目录号 产品名 应用 反应物种
HY-P82756 ZBTB7A Antibody (YA2501) WB, IHC-P, ICC/IF, IP Human

关联疾病

疾病名称 别名
Macrocephaly, Neurodevelopmental Delay, Lymphoid Hyperplasia, And Persistent Fetal Hemoglobin

MNDLFH
Photosensitive Epilepsy

Pse

Photogenic Epilepsy

Photoparoxysmal Response

Reflex Epilepsy, Photosensitive

Photoparoxysmal Response 1
Endometrial Mixed Adenocarcinoma
Fetal Hemoglobin Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin

Delta-Beta-Thalassemia

Delta-Beta Thalassemia

Delta Beta-Thalassemia

HBFQTL1

Hemoglobin F, Hereditary Persistence Of

Hpfh

Hereditary Persistence Of Fetal Hemoglobin, Hb Gene Cluster-Related

Hemoglobin, Fetal, Quantitative Trait Locus 1

Hereditary Persistence Of Fetal Hemoglobin Thalassemia

Hpfh - [Hereditary Persistence Of Fetal Haemoglobin]

Fetal Haemoglobin

Persistence Of Fetal Haemoglobin

Persistent Haemoglobin F
Hemoglobinopathy

Hemoglobinopathies
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-152775 RK-701 Inhibitor 98.04% 否
HY-RS15979 ZBTB7A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ZBTB7A MGD MGI:1335091
Rattus norvegicus ZBTB7A RGD RGD:620946
Canis familiaris ZBTB7A VGNC VGNC:48544
Bos taurus ZBTB7A VGNC VGNC:37089
Others ZBTB7A NCBI
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