2. Gene
  3. SCARA3 - scavenger receptor class A member 3 Gene

SCARA3 - scavenger receptor class A member 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：清道夫受体 A 类成员 3

种属: Homo sapiens

同用名: CSR; APC7; CSR1; MSLR1; MSRL1

基因 ID: 51435 | 基因类型: protein coding

关于 SCARA3

Cytogenetic location: 8p21.1 Genomic coordinates (GRCh38): 8:27,633,463-27,734,141 (from NCBI)

This gene has 2 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in endometrium (RPKM 16.5), brain (RPKM 14.0) and 23 other tissues.

功能概要

该基因编码巨噬细胞清道夫受体样蛋白。这种蛋白质已被证明可以消耗活性氧，因此在保护细胞免受氧化应激方面发挥重要作用。该基因的表达是由氧化应激诱导的。已经描述了编码不同同种型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a macrophage scavenger receptor-like protein. This protein has been shown to deplete Reactive Oxygen Species, and thus play an important role in protecting cells from oxidative stress. The expression of this gene is induced by oxidative stress. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

SCARA3 基因产物(2)

mRNA Protein Name
NM_016240.3 NP_057324.2 scavenger receptor class A member 3 isoform 1
NM_182826.2 NP_878185.1 scavenger receptor class A member 3 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
NOT involved in toll-like receptor 3 signaling pathway IMP
IMP: 通过突变表型推断
25204797 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SCARA3 蛋白结构

Collagen

Collagen: Collagen triple helix repeat (20 copies) (456 - 512)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (499 - 557)

Collagen

Collagen: Collagen triple helix repeat (20 copies) (544 - 602)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 606 a.a.
蛋白主名 其他名称

scavenger receptor class A member 3

cellular stress response gene protein

SCARA3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SCARA3 Q6AZY7 COLEC12 Homo sapiens Q5KU26
Anti Tag CoIP
33961781
种属内
SCARA3 Q6AZY7 SYNGR2 Homo sapiens O43760
Validated Y2H
25416956
种属内
SCARA3 Q6AZY7 SYNGR2 Homo sapiens O43760
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hand, Foot And Mouth Disease

Vesicular Stomatitis And Exanthem
Coffin-Siris Syndrome 3

CSS3

Mrd15

Mental Retardation, Autosomal Dominant 15

Autosomal Dominant Mental Retardation 15

Coffin-Siris Syndrome, Type 3
Flinders Island Spotted Fever

Fisf

Thai Tick Typhus
Queensland Tick Typhus

Australian Tick Typhus

North Queensland Tick Typhus

Rickettsia Australis Spotted Fever
Mouth Disease

Mouth Diseases

Mouth Disorders
Osteogenesis Imperfecta, Type Ii

Vrolik Type Of Osteogenesis Imperfecta

Osteogenesis Imperfecta Type 2

OI2

Oi, Type Ii

Osteogenesis Imperfecta Congenita

Oic

Osteogenesis Imperfecta Type Ii

Lethal Osteogenesis Imperfecta

Oi Type 2

Osteogenesis Imperfecta Congenita Perinatal Lethal Form

Osteogenesis Imperfecta Congenita, Perinatal Lethal Form

Perinatal Lethal Osteogenesis Imperfecta Congenita

Perinatally Lethal Oi

Osteogenesis Imperfecta 2

Oi-Ii

Oi-Iia

Oi Type Iia

Osteogenesis Imperfecta Type Iia

Osteogenesis Imperfecta Type Ii Autosomal Dominant

Oi Type Ii

Osteogenesis Imperfecta, Dominant Perinatal Lethal
Osteogenesis Imperfecta, Type I

Osteogenesis Imperfecta Type I

OI1

Oi, Type I

Osteogenesis Imperfecta Tarda

Osteogenesis Imperfecta With Blue Sclerae

Osteogenesis Imperfecta Type 1

Adair-Dighton Syndrome

Mild Osteogenesis Imperfecta

Non-Deforming Osteogenesis Imperfecta

Oi Type 1

Van Der Hoeve Syndrome

Classic Non-Deforming Oi With Blue Sclerae

Osteogenesis Imperfecta 1

Oi-I

Osteopenic Non-Fracture Syndrome

Osteogenesis Imperfecta, Mild

Osteogenesis Imperfecta

Lobstein'S Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12486 SCARA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SCARA3 VGNC VGNC:81561
Canis familiaris SCARA3 VGNC VGNC:45896
Rattus norvegicus SCARA3 RGD RGD:1309269
Felis catus SCARA3 VGNC VGNC:80000
Bos taurus SCARA3 VGNC VGNC:34322
Mus musculus SCARA3 MGD MGI:2444418
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