2. Gene
  3. RNF138 - ring finger protein 138 Gene

RNF138 - ring finger protein 138 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：无名指蛋白 138

种属: Homo sapiens

同用名: NARF; HSD-4; STRIN; hNARF

基因 ID: 51444 | 基因类型: protein coding

关于 RNF138

Cytogenetic location: 18q12.1 Genomic coordinates (GRCh38): 18:32,091,874-32,131,561 (from NCBI)

This gene has 9 transcripts (splice variants), 162 orthologues and 4 paralogues. Broad expression in testis (RPKM 31.9), bone marrow (RPKM 30.7) and 23 other tissues.

功能概要

由该基因编码的蛋白质包含一个无名指，这是一种存在于各种功能不同的蛋白质中的基序，并且已知参与蛋白质-DNA 和蛋白质-蛋白质相互作用。已经观察到编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

RNF138 基因产物(3)

mRNA Protein Name
NM_001191324.2 NP_001178253.2 E3 ubiquitin-protein ligase RNF138 isoform 1
NM_016271.5 NP_057355.2 E3 ubiquitin-protein ligase RNF138 isoform 1
NM_198128.3 NP_937761.1 E3 ubiquitin-protein ligase RNF138 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19549727 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
16714285 GOA
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
26502055 GOA
enables ubiquitin protein ligase activity IMP
IMP: 通过突变表型推断
26502055 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA double-strand break processing involved in repair via single-strand annealing IMP
IMP: 通过突变表型推断
26502057 GOA
involved in double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
26502055 GOA
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
26502055 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in site of double-strand break IDA
IDA: 通过直接分析推断
26502055 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

RNF138 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (18 - 57)

zf-Di19

zf-Di19: Drought induced 19 protein (Di19), zinc-binding (156 - 216)

  • 0
  • 100
  • 200
  • 245 a.a.
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF138

NLK-associated RING finger protein

RNF138 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra RNF138 Q8WVD3 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra RNF138 Q8WVD3 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra RNF138 Q8WVD3 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra RNF138 Q8WVD3 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra RNF138 Q8WVD3 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra RNF138 Q8WVD3 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra RNF138 Q8WVD3 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra RNF138 Q8WVD3 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra RNF138 Q8WVD3 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 HRAS Homo sapiens P01112
Validated Y2H
32814053
Intra RNF138 Q8WVD3 HRAS Homo sapiens P01112
Y2H Array
32814053
Intra RNF138 Q8WVD3 HRAS Homo sapiens P01112
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra RNF138 Q8WVD3 GSN Homo sapiens P06396
Y2H Array
32814053
Intra RNF138 Q8WVD3 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra RNF138 Q8WVD3 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Validated Y2H
32814053
Intra RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Y2H Array
32814053
Intra RNF138 Q8WVD3 UBE2K Homo sapiens P61086
Y2H
19549727
Intra RNF138 Q8WVD3 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra RNF138 Q8WVD3 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra RNF138 Q8WVD3 HTRA2 Homo sapiens O43464
Validated Y2H
32814053
Intra RNF138 Q8WVD3 HTRA2 Homo sapiens O43464
Y2H Array
32814053
Intra RNF138 Q8WVD3 HTRA2 Homo sapiens O43464
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
Intra RNF138 Q8WVD3 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
Intra RNF138 Q8WVD3 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
Intra RNF138 Q8WVD3 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12050 RNF138 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus RNF138 RGD RGD:621485
Mus musculus RNF138 MGD MGI:1929211
Felis catus RNF138 VGNC VGNC:80479
Canis familiaris RNF138 VGNC VGNC:45631
Macaca mulatta RNF138 VGNC VGNC:76755
Bos taurus RNF138 VGNC VGNC:34022
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