REV1 - REV1 DNA directed polymerase Gene

中文名称：REV1 DNA 定向聚合酶

种属: Homo sapiens

同用名: REV1L; AIBP80

基因 ID: 51455 | 基因类型: protein coding

关于 REV1

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:99,400,477-99,490,202 (from NCBI)

This gene has 16 transcripts (splice variants), 208 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 6.5), testis (RPKM 6.4) and 25 other tissues.

功能概要

该基因编码的蛋白质与酿酒酵母诱变蛋白 Rev1 具有相似性。 Rev1 蛋白包含一个 BRCT 结构域，这在蛋白质-蛋白质相互作用中很重要。人类 Rev1 样蛋白的一个建议作用是作为支架，招募参与受损 DNA 的跨损伤合成 (TLS) 的 DNA 聚合酶。[RefSeq 提供，2016 年 3 月]

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

REV1 基因产物(7)

mRNA	Protein	Name
NM_001037872.3	NP_001032961.1	DNA repair protein REV1 isoform 2
NM_001321454.2	NP_001308383.1	DNA repair protein REV1 isoform 3
NM_001321455.2	NP_001308384.1	DNA repair protein REV1 isoform 4
NM_001321458.2	NP_001308387.1	DNA repair protein REV1 isoform 5
NM_001321459.2	NP_001308388.1	DNA repair protein REV1 isoform 6
NM_001321460.2	NP_001308389.1	DNA repair protein REV1 isoform 6
NM_016316.4	NP_057400.1	DNA repair protein REV1 isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	11485998	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in response to UV	IDA IDA: 通过直接分析推断	11485998	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

REV1 蛋白结构

BRCT

IMS

IMS_C

0
200
400
600
800
1000
1251 a.a.

蛋白主名

其他名称

DNA repair protein REV1

REV1 homolog

REV1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	REV1	Q9UBZ9	FAAP20	Homo sapiens	Q6NZ36	NMR	26318859

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis	KMIN
Kin	Systemic Karyomegaly
Karyomegalic Tubulointerstitial Nephritis	Ktn

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-126214	JH-RE-06	Inhibitor	99.81%	否
HY-126214S	JH-RE-06-d6	Inhibitor	98.04%	否
HY-RS11861	REV1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-117846	MLAF50	Agonist	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	REV1	RGD	RGD:1306715
Canis familiaris	REV1	VGNC	VGNC:45487
Felis catus	REV1	VGNC	VGNC:64579
Macaca mulatta	REV1	VGNC	VGNC:106209
Bos taurus	REV1	VGNC	VGNC:33882
Mus musculus	REV1	MGD	MGI:1929074
Others	REV1	NCBI

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