2. Gene
  3. PDK2 - pyruvate dehydrogenase kinase 2 Gene

PDK2 - pyruvate dehydrogenase kinase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：丙酮酸脱氢酶激酶 2

种属: Homo sapiens

同用名: PDHK2; PDKII

基因 ID: 5164 | 基因类型: protein coding

关于 PDK2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,094,737-50,112,152 (from NCBI)

This gene has 16 transcripts (splice variants), 236 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 32.6), heart (RPKM 32.6) and 24 other tissues.

功能概要

该基因编码丙酮酸脱氢酶激酶家族的成员。编码的蛋白质磷酸化丙酮酸脱氢酶，下调线粒体丙酮酸脱氢酶复合物的活性。该基因的过度表达可能在癌症和糖尿病中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2010 年 12 月]

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both Cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

PDK2 基因产物(4)

mRNA Protein Name
NM_001199898.2 NP_001186827.1 pyruvate dehydrogenase kinase, isozyme 2 isoform 2
NM_001199899.2 NP_001186828.1 pyruvate dehydrogenase kinase, isozyme 2 isoform 2
NM_001199900.2 NP_001186829.1 pyruvate dehydrogenase kinase, isozyme 2 isoform 3 precursor
NM_002611.5 NP_002602.2 pyruvate dehydrogenase kinase, isozyme 2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
16401071 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16169070 GOA
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
19833728 GOA
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity IDA
IDA: 通过直接分析推断
19833728 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to reactive oxygen species IMP
IMP: 通过突变表型推断
21283817 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
22123926 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PDK2 蛋白结构

BCDHK_Adom3

BCDHK_Adom3: Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase (30 - 192)

HATPase_c

HATPase_c: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (241 - 361)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

pyruvate dehydrogenase kinase, isozyme 2

PDH kinase 2

PDK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PDK2 Q15119 HTT Homo sapiens P42858
Y2H Pooling
16169070
种属间: 跨种属相互作用 种属内: 同种属相互作用

PDK2 抗体

目录号 产品名 应用 反应物种
HY-P81650 PDK2 Antibody (YA1395) WB, IHC-P, ICC/IF, IP, FC Human, Mouse, Rat

关联疾病

疾病名称 别名
Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type

Adpkd

Polycystic Kidney Diseases

Polycystic Kidney, Autosomal Dominant

Congenital Biliary Ectasias

Polycystic Kidney And Hepatic Disease 1

Polycystic Kidney Disease, Autosomal Dominant

Kidney, Polycystic, Disease, Autosomal Dominant

Adult Polycystic Kidney Disease

Polycystic Kidney, Adult Type

Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease

Polycystic Kidney Diseases

Pkd

Polycystic Renal Disease

Kidney Disease, Polycystic

Polycystic Kidney, Autosomal Dominant
Esophageal Adenosquamous Carcinoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-121744 PS10 Inhibitor 99.01% 否
HY-12492 VER-246608 Inhibitor 98.92% 否
HY-19564 JX06 99.78% 否
HY-18676B ILK-IN-2 99.41% 否
HY-RS10276 PDK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PDK2 MGD MGI:1343087
Felis catus PDK2 VGNC VGNC:97550
Macaca mulatta PDK2 VGNC VGNC:75933
Canis familiaris PDK2 VGNC VGNC:44381
Bos taurus PDK2 VGNC VGNC:32704
Rattus norvegicus PDK2 RGD RGD:69428
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