TRAPPC2L - trafficking protein particle complex subunit 2L Gene

中文名称：运输蛋白颗粒复合物亚基 2L

种属: Homo sapiens

同用名: PERRB; HSPC176

基因 ID: 51693 | 基因类型: protein coding

关于 TRAPPC2L

Cytogenetic location: 16q24.3 Genomic coordinates (GRCh38): 16:88,856,220-88,862,678 (from NCBI)

This gene has 16 transcripts (splice variants), 202 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in adrenal (RPKM 16.3), testis (RPKM 13.9) and 25 other tissues.

功能概要

该基因编码一种与束缚因子运输蛋白颗粒 (TRAPP 复合物) 相互作用的蛋白质。 TRAPP 复合物介导囊泡和靶膜之间的接触，因此参与囊泡介导的蛋白质和脂质转运。编码的蛋白质与 X 连锁运输蛋白颗粒复合物 2 有关。相关的假基因位于 X 染色体上。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a protein that interacts with the tethering factor trafficking protein particle (TRAPP complex). TRAPP complexes mediate the contact between vescicles and target membranes, and thus, are involved in vescicle-mediated transport of proteins and lipids. The encoded protein is related to the X-linked trafficking protein particle complex 2. A related pseudogene is located on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

TRAPPC2L 基因产物(9)

mRNA	Protein	Name
NM_001318524.2	NP_001305453.1	trafficking protein particle complex subunit 2-like protein isoform 1
NM_001318525.2	NP_001305454.1	trafficking protein particle complex subunit 2-like protein isoform 3
NM_001318526.2	NP_001305455.1	trafficking protein particle complex subunit 2-like protein isoform 4
NM_001318527.2	NP_001305456.1	trafficking protein particle complex subunit 2-like protein isoform 5
NM_001318528.2	NP_001305457.1	trafficking protein particle complex subunit 2-like protein isoform 6
NM_001318529.2	NP_001305458.1	trafficking protein particle complex subunit 2-like protein isoform 7
NM_001318530.2	NP_001305459.1	trafficking protein particle complex subunit 2-like protein isoform 8
NM_001318532.2	NP_001305461.1	trafficking protein particle complex subunit 2-like protein isoform 9
NM_016209.5	NP_057293.1	trafficking protein particle complex subunit 2-like protein isoform 2

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of TRAPP complex	IDA IDA: 通过直接分析推断	21525244	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRAPPC2L 蛋白结构

Sedlin_N

0
100
140 a.a.

蛋白主名

其他名称

trafficking protein particle complex subunit 2-like protein

hematopoietic stem/progenitor cells 176

TRAPPC2L 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRAPPC2L	Q9UL33	CEP57L1	Homo sapiens	Q8IYX8-2	Validated Y2H	25416956
种属内	TRAPPC2L	Q9UL33	CEP57L1	Homo sapiens	Q8IYX8-2	Y2H Array	25416956
种属内	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-2	Y2H Array	25416956
种属内	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-2	Y2H Prey Pooling	25416956
种属内	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-3	Y2H Prey Pooling	25416956
种属内	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-3	Validated Y2H	25416956
种属内	TRAPPC2L	Q9UL33	REPS1	Homo sapiens	Q96D71-3	Y2H Array	25416956
种属内	TRAPPC2L	Q9UL33	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	25416956
种属内	TRAPPC2L	Q9UL33	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	25416956
种属内	TRAPPC2L	Q9UL33	TRAPPC8	Homo sapiens	Q9Y2L5	Anti Tag CoIP	33961781
种属内	TRAPPC2L	Q9UL33	TRAPPC8	Homo sapiens	Q9Y2L5	Anti Tag CoIP	21453443
种属内	TRAPPC2L	Q9UL33	TRAPPC13	Homo sapiens	A5PLN9	Anti Tag CoIP	21453443
种属内	TRAPPC2L	Q9UL33	TRAPPC13	Homo sapiens	A5PLN9	Anti Tag CoIP	33961781
种属内	TRAPPC2L	Q9UL33	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
种属内	TRAPPC2L	Q9UL33	REL	Homo sapiens	Q04864	Y2H Array	25416956
种属内	TRAPPC2L	Q9UL33	TCF4	Homo sapiens	P15884	Y2H Array	25416956
种属内	TRAPPC2L	Q9UL33	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
种属内	TRAPPC2L	Q9UL33	TRIP6	Homo sapiens	Q15654	Y2H Prey Pooling	25416956
种属内	TRAPPC2L	Q9UL33	TRIP6	Homo sapiens	Q15654	Validated Y2H	25416956
种属内	TRAPPC2L	Q9UL33	TRIP6	Homo sapiens	Q15654	Y2H Array	25416956
种属内	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Y2H	21827752
种属内	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Anti Tag CoIP	21453443
种属内	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Validated Y2H	25416956
种属内	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Anti Tag CoIP	33961781
种属内	TRAPPC2L	Q9UL33	TRAPPC3	Homo sapiens	O43617	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Encephalopathy, Progressive, Early-Onset, With Episodic Rhabdomyolysis

PEERB

Mucopolysaccharidosis, Type Iva

Mps Iva	Galns Deficiency
MPS4A	Morquio A Disease
Galactosamine-6-Sulfatase Deficiency	Morquio Syndrome A
Mucopolysaccharidosis Iva	Mucopolysaccharidosis Type Iva
Mpsiva	Morquio Disease Type A
Mucopolysaccharidosis Type 4a	N-Acetylgalactosamine-6-Sulfate Sulfatase Deficiency
Morquio Syndrome Type A	Mps 4a
Morquio Disease, Type A	Mucopolysaccharidosis 4a
Morquio'S Syndrome A	Mps Iv A
Mucopolysaccharidosis Iv	Mucopolysaccharidosis, Mps-Iv-A

Kbg Syndrome

KBGS	Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies
Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies	Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies
Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome	Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Spondyloepiphyseal Dysplasia Tarda, X-Linked

Spondyloepiphyseal Dysplasia Tarda	X-Linked Spondyloepiphyseal Dysplasia Tarda
SEDT	Sed Tarda, X-Linked
Spondyloepiphyseal Dysplasia, Late	Spondyloepiphyseal Dysplasia Tarda X-Linked
Sed	X Linked Spondyloepiphyseal Dysplasia Tarda
X-Linked Spondyloepiphyseal Dysplasia	Late Onset Spondyloepiphyseal Dysplasia
Sed Tarda	X-Linked Sed
X-Linked Sedt	Dysplasia, Spondyloepiphyseal, Tarda
Spondyloepiphyseal Dysplasia

Neu-Laxova Syndrome 2

NLS2

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive	Autosomal Recessive Mental Retardation
Autosomal Recessive Non-Syndromic Mental Retardation	Autosomal Recessive Non-Syndromic Intellectual Disability

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS14989	TRAPPC2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	TRAPPC2L	RGD	RGD:1304906
Bos taurus	TRAPPC2L	VGNC	VGNC:36287
Mus musculus	TRAPPC2L	MGD	MGI:1916295
Canis familiaris	TRAPPC2L	VGNC	VGNC:47780

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