CD244 - CD244 molecule Gene

中文名称：CD244 分子

种属: Homo sapiens

同用名: 2B4; NAIL; Nmrk; NKR2B4; SLAMF4

基因 ID: 51744 | 基因类型: protein coding

关于 CD244

Cytogenetic location: 1q23.3 Genomic coordinates (GRCh38): 1:160,830,160-160,862,887 (from NCBI)

This gene has 5 transcripts (splice variants), 108 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in spleen (RPKM 7.3), bone marrow (RPKM 3.3) and 12 other tissues.

功能概要

该基因编码一种在自然杀伤 (NK) 细胞 (和一些 T 细胞) 上表达的细胞表面受体，该受体介导非主要组织相容性复合体 (MHC) 限制性杀伤。 NK 细胞和靶细胞之间通过该受体的相互作用被认为可以调节 NK 细胞的细胞溶解活性。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2009 年 10 月]

This gene encodes a cell surface receptor expressed on natural killer (NK) cells (and some T cells) that mediate non-major histocompatibility complex (MHC) restricted killing. The interaction between NK-cell and target cells via this receptor is thought to modulate NK-cell cytolytic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

CD244 基因产物(3)

mRNA	Protein	Name
NM_001166663.2	NP_001160135.1	natural killer cell receptor 2B4 isoform 2 precursor
NM_001166664.2	NP_001160136.1	natural killer cell receptor 2B4 isoform 3 precursor
NM_016382.4	NP_057466.1	natural killer cell receptor 2B4 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables MHC class I protein binding	IDA IDA: 通过直接分析推断	20164429	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11489943	GOA
enables signaling receptor activity	IDA IDA: 通过直接分析推断	27249817	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in natural killer cell activation	IDA IDA: 通过直接分析推断	27249817	GOA
involved in natural killer cell activation involved in immune response	IDA IDA: 通过直接分析推断	11714776	GOA
involved in positive regulation of granzyme B production	IDA IDA: 通过直接分析推断	11714776	GOA
involved in positive regulation of inositol phosphate biosynthetic process	IDA IDA: 通过直接分析推断	8376943	GOA
involved in positive regulation of interleukin-8 production	IDA IDA: 通过直接分析推断	8376943	GOA
involved in positive regulation of type II interferon production	IDA IDA: 通过直接分析推断	11714776	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	17213291	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CD244 蛋白结构

Receptor_2B4

Ig_2

0
100
200
300
370 a.a.

蛋白主名

其他名称

natural killer cell receptor 2B4

CD244 molecule, natural killer cell receptor 2B4

CD244 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CD244	Q9BZW8	INPP5D	Homo sapiens	Q92835	Pull Down	24642916
种属内	CD244	Q9BZW8	INPP5D	Homo sapiens	Q92835	SPR	26221972
种属内	CD244	Q9BZW8	INPP5D	Homo sapiens	Q92835	SPR	24642916
种属内	CD244	Q9BZW8	SH2D1A	Homo sapiens	O60880-1	Anti Tag CoIP	16983070
种属内	CD244	Q9BZW8	PTPN11	Homo sapiens	Q06124	SPR	24642916
种属内	CD244	Q9BZW8	PTPN11	Homo sapiens	Q06124	Pull Down	24642916
种属内	CD244	Q9BZW8	SH2D1B	Homo sapiens	O14796	Pull Down	24642916
种属内	CD244	Q9BZW8	SH2D1B	Homo sapiens	O14796	SPR	24642916
种属内	CD244	Q9BZW8	SH2D1B	Homo sapiens	O14796	Anti Bait CoIP	23346089
种属内	CD244	Q9BZW8	SH2D1A	Homo sapiens	O60880	SPR	24642916
种属内	CD244	Q9BZW8	SH2D1A	Homo sapiens	O60880	Pull Down	24642916
种属内	CD244	Q9BZW8	SH2D1A	Homo sapiens	O60880	Anti Bait CoIP	11489943
种属内	CD244	Q9BZW8	SH2D1A	Homo sapiens	O60880	Anti Bait CoIP	23346089
种属内	CD244	Q9BZW8	SH2D1A	Homo sapiens	O60880	SPR	26221972
种属内	CD244	Q9BZW8	B2M	Homo sapiens	P61769	Anti Bait CoIP	20164429
种属内	CD244	Q9BZW8	CD48	Homo sapiens	P09326	FACS	15153464
种属内	CD244	Q9BZW8	CD48	Homo sapiens	P09326	FACS	16002700
种属内	CD244	Q9BZW8	PTPN6	Homo sapiens	P29350	Pull Down	24642916
种属内	CD244	Q9BZW8	PTPN6	Homo sapiens	P29350	Anti Bait CoIP	11489943
种属内	CD244	Q9BZW8	PLCG1	Homo sapiens	P19174	SPR	24642916
种属内	CD244	Q9BZW8	PLCG1	Homo sapiens	P19174	Pull Down	24642916

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CD244 蛋白

目录号	产品名	蛋白编号	纯度
HY-P72745	2B4/CD244 Protein, Human (HEK293, His)	Q9BZW8-2 (C22-R221)	≥95%
HY-P78052	2B4/CD244 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9BZW8-2 (C22-R221)	≥95%
HY-P78366	2B4/CD244 Protein, Human (HEK293, Fc)	Q9BZW8-2 (C22-R221)	≥95%

CD244 抗体

目录号	产品名	应用	反应物种
HY-P81637	2B4 Antibody (YA1382)	ICC/IF, FC, ELISA	Human

关联疾病

疾病名称

别名

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Lymphoproliferative Syndrome

Lymphoproliferative Disorder	Lymphoproliferative Disorders
Lymphoproliferative Disorders, Susceptibility To

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis	Duncan Disease
Purtilo Syndrome	X-Linked Lymphoproliferative Syndrome
Xlp	X-Linked Lymphoproliferative Disease
XLP1	Lyp
Lymphoproliferative Disease, X-Linked	Xlpd
X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency	Ebv Infection, Severe, Susceptibility To
Ebvs	Immunodeficiency 5
Imd5	X-Linked Lymphoproliferative Syndrome 1
Epstein-Barr Virus Infection, Familial Fatal	Ebv Infection, Severe
Infectious Mononucleosis, Severe	Infectious Mononucleosis, Severe, Susceptibility To
Immunodeficiency, X-Linked Progressive Combined Variable	Epstein Barr Virus Infection, Familial Fatal
X-Linked Progressive Combined Variable Immunodeficiency 5	Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males
Familial Fatal Epstein-Barr Infection	Severe Susceptibility To Ebv Infection
Severe Susceptibility To Infectious Mononucleosis	Sap Deficiency
Sh2d1a/Slam-Associated Protein Deficiency	X-Linked Lymphoproliferative Syndrome Type 1
X-Linked Progressive Combined Variable Immunodeficiency	Lymphoproliferative Syndrome, X-Linked
Sap	X-Linked Lymphoproliferative Disorder

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Selective Immunoglobulin Deficiency Disease

Dysgammaglobulinemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02213	CD244 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CD244	MGD	MGI:109294
Bos taurus	CD244	VGNC	VGNC:27015
Rattus norvegicus	CD244	RGD	RGD:68400
Canis familiaris	CD244	VGNC	VGNC:53117
Macaca mulatta	CD244	VGNC	VGNC:70821
Felis catus	CD244	VGNC	VGNC:60599
Others	CD244	NCBI

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