PFKFB3 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Gene

中文名称：6-磷酸果糖-2-激酶/果糖-2,6-二磷酸酶 3

种属: Homo sapiens

同用名: PFK2; IPFK2; iPFK-2

关于 PFKFB3

功能概要

由该基因编码的蛋白质属于双功能蛋白家族，参与果糖-2,6-二磷酸的合成和降解，果糖是一种控制真核生物糖酵解的调节分子。编码的蛋白质具有 6-磷酸果糖-2-激酶活性，可催化果糖-2,6-二磷酸 (F2,6BP) 的合成，以及果糖-2,6-二磷酸酶活性，可催化 F2,6-BP 的降解。这种蛋白质是细胞周期进程和防止细胞凋亡所必需的。它作为细胞周期蛋白依赖性激酶 1 的调节剂发挥作用，将葡萄糖代谢与肿瘤细胞的细胞增殖和存活联系起来。已经为该基因发现了几种编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2016 年 4 月]

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of Apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]