1. Gene
  2. PIN4 - peptidylprolyl cis/trans isomerase, NIMA-interacting 4 Gene

PIN4 - peptidylprolyl cis/trans isomerase, NIMA-interacting 4 Gene

中文名称:肽基脯氨酰顺/反异构酶,NIMA 相互作用 4

种属: Homo sapiens

同用名: EPVH; PAR14; PAR17

基因 ID: 5303 | 基因类型: protein coding

关于 PIN4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:72,181,676-72,263,964 (from NCBI)

This gene has 9 transcripts (splice variants), 231 orthologues and 1 paralogue. Ubiquitous expression in liver (RPKM 5.5), kidney (RPKM 4.8) and 25 other tissues.

功能概要

该基因编码肽基-脯氨酰顺/反异构酶蛋白家族的 parvulin 亚家族成员。编码的蛋白质催化肽基脯氨酰键的异构化,并可能在细胞周期、染色质重塑和/或核糖体生物发生中发挥作用。编码的蛋白质可能在线粒体中发挥额外的作用。[RefSeq 提供,2009 年 12 月]

This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]

PIN4 基因产物(2)

mRNA Protein Name
NM_001170747.1 NP_001164218.1 peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 2
NM_006223.4 NP_006214.3 peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables bent DNA binding IDA
IDA: 通过直接分析推断
12144781 GOA
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
17875217 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in rRNA processing IMP
IMP: 通过突变表型推断
19369196 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12144781 GOA
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
17875217 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
19369196 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12144781 GOA
part of preribosome IDA
IDA: 通过直接分析推断
19369196 GOA
located in spindle IDA
IDA: 通过直接分析推断
19369196 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PIN4 蛋白结构

Rotamase_3

Rotamase_3: PPIC-type PPIASE domain (59 - 156)

  • 0
  • 100
  • 156 a.a.
蛋白主名 其他名称

peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

PPIase PIN4

重组 PIN4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71205 PIN4 Protein, Human (His) Q9Y237-2 (M1-K156) ≥95%

关联疾病

疾病名称 别名
Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus PIN4 VGNC VGNC:103741
Bos taurus PIN4 VGNC VGNC:32903
Rattus norvegicus PIN4 RGD RGD:1590326
Mus musculus PIN4 MGD MGI:1916963
Others PIN4 NCBI