PLCB3 - phospholipase C beta 3 Gene

中文名称：磷脂酶 C β 3

种属: Homo sapiens

同用名: SMDCD

基因 ID: 5331 | 基因类型: protein coding

关于 PLCB3

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:64,251,530-64,269,452 (from NCBI)

This gene has 4 transcripts (splice variants), 180 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in duodenum (RPKM 38.8), small intestine (RPKM 36.6) and 18 other tissues.

功能概要

该基因编码磷酸肌醇磷脂酶 C β 酶家族的成员，该酶家族在 G 蛋白相关受体介导的信号转导中催化从磷脂酰肌醇产生二级信使甘油二酯和肌醇 1,4,5-三磷酸。可变剪接导致多个转录变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of the phosphoinositide Phospholipase C beta Enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

PLCB3 基因产物(3)

mRNA	Protein	Name
NM_000932.5	NP_000923.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1
NM_001184883.2	NP_001171812.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 2
NM_001316314.3	NP_001303243.1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calmodulin binding	IDA IDA: 通过直接分析推断	12821674	GOA
enables molecular adaptor activity	EXP EXP: 通过实验结果推断	23377541	GOA
enables molecular adaptor activity	IDA IDA: 通过直接分析推断	23377541	GOA
enables molecular function activator activity	EXP EXP: 通过实验结果推断	23377541	GOA
enables phosphatidylinositol phospholipase C activity	IDA IDA: 通过直接分析推断	9188725	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21822282	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in phosphatidylinositol metabolic process	IDA IDA: 通过直接分析推断	9188725	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: 通过直接分析推断	20966218	GOA
involved in phospholipase C-activating serotonin receptor signaling pathway	IDA IDA: 通过直接分析推断	20966218	GOA
acts upstream of or within regulation of systemic arterial blood pressure	IDA IDA: 通过直接分析推断	18468998	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in cytoplasm	IDA IDA: 通过直接分析推断	29122926	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	18468998	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PLCB3 蛋白结构

EF-hand_like

PI-PLC-X

PI-PLC-Y

DUF1154

PLC-beta_C

0
200
400
600
800
1000
1234 a.a.

蛋白主名

其他名称

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3

PLC beta 3

PLCB3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属间	PLCB3	Q01970	Gnaq	Mus musculus	P21279	X-Ray Diffraction	23377541
种属间	PLCB3	Q01970	Gnaq	Mus musculus	P21279	Light Scattering	23377541
种属间	PLCB3	Q01970	Gnaq	Mus musculus	P21279	3D-EM	23377541
种属间	PLCB3	Q01970	Gnaq	Mus musculus	P21279	Competition Binding	23377541
种属间	PLCB3	Q01970	Gnaq	Mus musculus	P21279	GMS	23377541

种属间: 跨种属相互作用 种属内: 同种属相互作用

PLCB3 抗体

目录号	产品名	应用	反应物种
HY-P82949	Phospholipase C beta 3 Antibody (YA2694)	WB, IHC-P	Human

关联疾病

疾病名称

别名

Spondylometaphyseal Dysplasia With Corneal Dystrophy

SMDCD	Spondylometaphyseal Dysplasia-Corneal Dystrophy Syndrome
Smd-Corneal Dystrophy Syndrome

Multiple Endocrine Neoplasia

Men	Multiple Endocrine Adenomatosis
Multiple Endocrine Neoplasia Syndrome	Adenomatosis, Familial Endocrine
Endocrine Neoplasia, Multiple	Familial Endocrine Adenomatosis
Mea	Multiple Endocrine Neoplasms
Multiple Endocrine Neoplasia Type 1

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1	MEN1
Wermer Syndrome	Multiple Endocrine Neoplasia 1
Multiple Endocrine Neoplasia, Type 1	Men I
Endocrine Adenomatosis, Multiple	Mea I
Men Type I	Wermer'S Syndrome
Men1 Syndrome	Multiple Endocrine Adenomatosis
Endocrine Adenomatosis Multiple	Men 1
Familial Multiple Endocrine Neoplasia Type I	Neoplasia, Endocrine, Multiple, Type 1
Multiple Endocrine Neoplasia

Corneal Dystrophy

Spinocerebellar Ataxia, Autosomal Recessive 13

Autosomal Recessive Spinocerebellar Ataxia 13	SCAR13
Autosomal Recessive Congenital Cerebellar Ataxia Due To Mglur1 Deficiency	Autosomal Recessive Congenital Cerebellar Ataxia Due To Metabotropic Glutamate Receptor 1 Deficiency
Autosomal Recessive Spinocerebellar Ataxia Type 13	Spinocerebellar Ataxia, Autosomal Recessive, 13
Ataxia, Spinocerebellar, Autosomal Recessive, Type 13

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10654	PLCB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	PLCB3	VGNC	VGNC:68894
Bos taurus	PLCB3	VGNC	VGNC:32982
Macaca mulatta	PLCB3	VGNC	VGNC:76165
Canis familiaris	PLCB3	VGNC	VGNC:52035
Mus musculus	PLCB3	MGD	MGI:104778
Rattus norvegicus	PLCB3	RGD	RGD:61993

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PLCB3 - phospholipase C beta 3 Gene

关于 PLCB3

功能概要

PLCB3 基因产物(3)

PLCB3 蛋白结构

PLCB3 蛋白互作信息

PLCB3 抗体

关联疾病

直系同源

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PLCB3 - phospholipase C beta 3 Gene

关于 PLCB3

功能概要

PLCB3 基因产物(3)

PLCB3 蛋白结构

PLCB3 蛋白互作信息

PLCB3 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z