SPA17 - sperm autoantigenic protein 17 Gene

中文名称：精子自身抗原蛋白 17

种属: Homo sapiens

同用名: CT22; SP17; SP17-1

基因 ID: 53340 | 基因类型: protein coding

关于 SPA17

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:124,673,904-124,697,518 (from NCBI)

This gene has 4 transcripts (splice variants), 148 orthologues and 2 paralogues. Biased expression in testis (RPKM 85.4), thyroid (RPKM 7.4) and 2 other tissues.

功能概要

该基因编码存在于细胞表面的蛋白质。 N 末端与人 cAMP 依赖性蛋白激酶 A (PKA) II 型α调节亚基 (RIIa) 具有序列相似性，而 C 末端具有 IQ 钙调蛋白结合基序。该蛋白质的中心部分具有碳水化合物结合基序，可能在细胞间粘附中发挥作用。该蛋白质最初的特征在于其参与精子与卵母细胞透明带的结合。最近的研究表明，它还参与额外的细胞间粘附功能，如免疫细胞迁移和转移。染色体 10q22 上存在逆转录假基因。[RefSeq 提供，2009 年 1 月]

This gene encodes a protein present at the cell surface. The N-terminus has sequence similarity to human cAMP-dependent protein kinase A (PKA) type II alpha regulatory subunit (RIIa) while the C-terminus has an IQ calmodulin-binding motif. The central portion of the protein has carbohydrate binding motifs and likely functions in cell-cell adhesion. The protein was initially characterized by its involvement in the binding of sperm to the zona pellucida of the oocyte. Recent studies indicate that it is also involved in additional cell-cell adhesion functions such as immune cell migration and metastasis. A retrotransposed pseudogene is present on chromosome 10q22.[provided by RefSeq, Jan 2009]

SPA17 基因产物(1)

mRNA	Protein	Name
NM_017425.4	NP_059121.1	sperm surface protein Sp17

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15257753	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cilium	IDA IDA: 通过直接分析推断	18421703	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	18421703	GOA
located in motile cilium	IDA IDA: 通过直接分析推断	18421703	GOA
located in sperm fibrous sheath	IDA IDA: 通过直接分析推断	19604394	GOA
located in sperm principal piece	IDA IDA: 通过直接分析推断	15257753	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPA17 蛋白结构

RIIa

0
100
151 a.a.

蛋白主名

其他名称

sperm surface protein Sp17

cancer/testis antigen 22

重组 SPA17 蛋白

目录号	产品名	蛋白编号	纯度
HY-P701069	SP-17 Protein, Human (His)	Q15506 (M1-K151)	≥95%

关联疾病

疾病名称

别名

Testicular Cancer

Testis Cancer	Testicular Carcinoma
Testicular Neoplasms	Malignant Neoplasm Of Testis
Childhood Neoplasm Of The Testis	Neoplasm Of Testis
Pediatric Testicular Neoplasm	Testicular Tumor
Testis Neoplasm	Testicular Tumors
Testicular Neoplasm	Testicular Malignant Germ Cell Tumor
Childhood Testicular Neoplasm	Carcinoma Of The Testis
Cancer Of Testis	Malignant Neoplasm Of Testis, Nos
Malignant Neoplasm Of Testis, Unspecified	Malignant Tumour Of Testis
Testicle Cancer	Primary Malignant Neoplasm Of Testis

Pelvic Varices

Varix Of Pelvis

Pelvic Varicose Vein

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Myeloma, Multiple

Multiple Myeloma	Plasma Cell Myeloma
Kahler Disease	Myelomatosis
Medullary Plasmacytoma	Multiple Myeloma, Resistance To
Myeloma	Plasma Cell Dyscrasia
Kahler'S Disease	Multiple Myeloma, Susceptibility To
Myeloma - Multiple	Kahler-Bozzolo Disease
Plasma Cell Myelomas	MM
Plasma Cell Neoplasm	Primary Systemic Amyloidosis
Primary Amyloidosis	Immunoglobulin Deposition Disease
Plasmacytic Myeloma	Multiple Myelomata
Multiple Myeloma Nos	Multiple Myeloma Without Mention Of Remission
Monostotic Plasma Cell Myeloma	Mm - [Multiple Myeloma]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13613	SPA17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SPA17	RGD	RGD:620154
Canis familiaris	SPA17	VGNC	VGNC:46691
Felis catus	SPA17	VGNC	VGNC:81934
Macaca mulatta	SPA17	VGNC	VGNC:77848
Bos taurus	SPA17	VGNC	VGNC:35160
Mus musculus	SPA17	MGD	MGI:1333778
Others	SPA17	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SPA17 - sperm autoantigenic protein 17 Gene

关于 SPA17

功能概要

SPA17 基因产物(1)

SPA17 蛋白结构

重组 SPA17 蛋白

关联疾病

直系同源

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SPA17 - sperm autoantigenic protein 17 Gene

关于 SPA17

功能概要

SPA17 基因产物(1)

SPA17 蛋白结构

重组 SPA17 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z