1. Gene
  2. PLD2 - phospholipase D2 Gene

PLD2 - phospholipase D2 Gene

中文名称:磷脂酶 D2

种属: Homo sapiens

同用名: PLD1C

基因 ID: 5338 | 基因类型: protein coding

关于 PLD2

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,807,152-4,823,430 (from NCBI)

This gene has 15 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in esophagus (RPKM 17.0), skin (RPKM 14.6) and 23 other tissues.

功能概要

该基因编码的蛋白质催化磷脂酰胆碱水解为磷脂酸和胆碱。磷脂酰肌醇 4,5-二磷酸和 ADP-核糖基化因子-1 可增强编码酶的活性。这种蛋白质定位于外周膜,可能参与细胞骨架组织、细胞周期控制、转录调节和/或调节分泌。已发现该基因编码不同亚型的两个转录变体。[RefSeq 提供,2011 年 7 月]

The protein encoded by this gene catalyzes the hydrolysis of phosphatidylcholine to phosphatidic acid and choline. The activity of the encoded Enzyme is enhanced by phosphatidylinositol 4,5-bisphosphate and ADP-ribosylation factor-1. This protein localizes to the peripheral membrane and may be involved in cytoskeletal organization, cell cycle control, transcriptional regulation, and/or regulated secretion. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]

PLD2 基因产物(2)

mRNA Protein Name
NM_001243108.2 NP_001230037.1 phospholipase D2 isoform PLD2B
NM_002663.5 NP_002654.3 phospholipase D2 isoform PLD2A
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16407827 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PLD2 蛋白结构

PX

PX: PX domain (65 - 192)

PLDc

PLDc: Phospholipase D Active site motif (437 - 464)

PLDc_2

PLDc_2: PLD-like domain (628 - 795)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 933 a.a.
蛋白主名 其他名称

phospholipase D2

choline phosphatase 2

PLD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PLD2 O14939 CFL1 Homo sapiens P23528 17853892
种属内
PLD2 O14939 CFL1 Homo sapiens P23528 17853892
种属内
PLD2 O14939 GRB2 Homo sapiens P62993 16407827
种属内
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
种属内
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
种属内
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
种属内
PLD2 O14939 RAC2 Homo sapiens P15153 22106281
种属内
PLD2 O14939 APP Homo sapiens P05067 32814053
种属内
PLD2 O14939 APP Homo sapiens P05067 32814053
种属内
PLD2 O14939 APP Homo sapiens P05067 32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Parkinson Disease 6, Autosomal Recessive Early-Onset

Autosomal Recessive Early-Onset Parkinson Disease 6

Parkinson Disease 6

PARK6

Parkinson Disease 6, Early Onset

Parkinson'S Disease 6

Parkinson Disease 6, Early-Onset

Autosomal Recessive Early-Onset Parkinson'S Disease 6

Early-Onset Parkinson Disease 6

Autosomal Recessive Early-Onset Parkinson Disease Type 6

Parkinson Disease 6 Early-Onset

Parkinson Disease 6 Late-Onset Susceptibility To

Parkinson Disease Autosomal Recessive Early-Onset Digenic Pink1/Dj1

Parkinsonism Young Adult Onset

Parkinson Disease, Autosomal Recessive Early-Onset, Digenic, Pink1/Dj1

Parkinson Disease, Type 6, Autosomal Recessive, Early-Onset

Ewing Sarcoma

Neuroepithelioma

Ewing'S Tumor

Primitive Neuroectodermal Tumor

Ewings Sarcoma

Ewing'S Sarcoma

Peripheral Neuroepithelioma

ES

Ewings Sarcoma-Primitive Neuroectodermal Tumor

Localized Peripheral Primitive Neuroectodermal Tumor

Peripheral Primitive Neuroectodermal Tumor

Ewing Tumor

Sarcoma, Ewing'S

Ewing Family Of Tumors

Extraosseous Ewing Tumor

Askin Tumor

Ewing'S Family Localized Tumor

Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing Sarcoma

Localized Ewing'S Sarcoma

Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor

Localized Ewing'S Tumor

Pnet Of Thoracopulmonary Region

Tumor Of The Ewing Family

Skeletal Ewing Sarcoma

Osseous Ewing Sarcoma

Ppnet

Peripheral Pnet

Extraskeletal Ewing Sarcoma

Eoe

Extraosseous Ewing Sarcoma

Extraskeletal Ewing Tumor

Esft

Ewing Sarcoma Family Of Tumors

Pne

Pnet

Pnet Of The Chest Wall

Sarcoma, Ewing

Neuroectodermal Tumors, Primitive, Peripheral

Neuroectodermal Tumor, Primitive

Disorder Of Eye

Askin'S Tumor

Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor

Neuroepithelioma, Peripheral

Pheochromocytoma

Pheochromocytoma, Susceptibility To

Phaeochromocytoma

Adrenal Gland Chromaffin Paraganglioma

Adrenal Gland Chromaffinoma

Adrenal Gland Paraganglioma

Adrenal Gland Pheochromocytoma

Chromaffin Paraganglioma Of The Adrenal Gland

Intraadrenal Paraganglioma

PCC

Chromaffin Cell Tumor

Medullary Chromaffinoma

Medullary Paraganglioma

Pheochromoblastoma

Pheochromocytomas

Chromaffin Cell Neoplasm

Pheochromocytoma, Malignant

Hermansky-Pudlak Syndrome 1

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells

HPS1

Delta Storage Pool Disease

Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial

Hermansky-Pudlak Syndrome, Type 1

Platelet Storage Pool Deficiency

Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PLD2 RGD RGD:3350
Bos taurus PLD2 VGNC VGNC:32996
Mus musculus PLD2 MGD MGI:892877
Felis catus PLD2 VGNC VGNC:68902
Canis familiaris PLD2 VGNC VGNC:44661
Macaca mulatta PLD2 VGNC VGNC:76172